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Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

Blood, 2016-01, Vol.127 (1), p.42-52

2016

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The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

Nature communications, 2021-09, Vol.12 (1), p.5679-13, Article 5679

2021

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Hitting the target in IDH2 mutant AML

Blood, 2017-08, Vol.130 (6), p.693-694

Wouters, Bas J.

2017

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Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia: Emerging Options and Pending Questions

HemaSphere, 2021-06, Vol.5 (6), p.e583-n/a

Wouters, Bas J.

2021

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Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

Cancer discovery, 2017-08, Vol.7 (8), p.868-883

2017

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Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia

Nature communications, 2024-07, Vol.15 (1), p.5693-22, Article 5693

2024

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Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

Blood, 2009-03, Vol.113 (13), p.3088-3091

2009

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Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

Haematologica (Roma), 2009-01, Vol.94 (1), p.131-134

2009

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Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

Blood, 2021-07, Vol.138 (2), p.160-177

2021

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BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Blood, 2021-02, Vol.137 (6), p.812-825

2021

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Minimal Residual Disease Monitoring of Acute Myeloid Leukemia by Massively Multiplex Digital PCR in Patients with NPM1 Mutations

The Journal of molecular diagnostics : JMD, 2017-07, Vol.19 (4), p.537-548

2017

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A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects

Blood, 2009-01, Vol.113 (2), p.291-298

2009

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Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers

Blood, 2011-07, Vol.118 (4), p.1069-1076

2011

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Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia

Cancer cell, 2006-11, Vol.10 (5), p.401-411

2006

Volltextzugriff (PDF)

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Blood, 2007-11, Vol.110 (10), p.3706-3714

2007

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Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features

Blood, 2009-03, Vol.113 (12), p.2795-2804

2009

Volltextzugriff (PDF)

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status

Blood, 2009-10, Vol.114 (14), p.3001-3007

2009

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3100 – DEVELOPING NEXT-GENERATION DRUG SENSITIVITY SCREENING USING PRIMARY TUMOR SPECIMENS DERIVED FROM PATIENTS OF MYELOID MALIGNANCIES

Experimental hematology, 2023, Vol.124, p.S100

2023

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Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation

BMC bioinformatics, 2007-01, Vol.8 (1), p.14-14, Article 14

2007

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HAT: hypergeometric analysis of tiling-arrays with application to promoter-GeneChip data

BMC bioinformatics, 2010-05, Vol.11 (1), p.275-275, Article 275

2010

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A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling–based clustering of AML

Blood, 2007-01, Vol.109 (1), p.389-390

2007

Volltextzugriff (PDF)

Gene expression profiling for improved dissection of acute leukemia: A recently identified immature myeloid/T-lymphoid subgroup as an example

Blood cells, molecules, & diseases, 2008-05, Vol.40 (3), p.395-400

2008

Volltextzugriff (PDF)

A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3β as a novel tumor suppressor in lung cancer

Cancer research (Chicago, Ill.), 2004-06, Vol.64 (12), p.4137-4147

2004

Volltextzugriff (PDF)

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Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

Hitting the target in IDH2 mutant AML

Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia: Emerging Options and Pending Questions

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Minimal Residual Disease Monitoring of Acute Myeloid Leukemia by Massively Multiplex Digital PCR in Patients with NPM1 Mutations

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects

Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers

Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status

3100 – DEVELOPING NEXT-GENERATION DRUG SENSITIVITY SCREENING USING PRIMARY TUMOR SPECIMENS DERIVED FROM PATIENTS OF MYELOID MALIGNANCIES

Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation

HAT: hypergeometric analysis of tiling-arrays with application to promoter-GeneChip data

A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling–based clustering of AML

Gene expression profiling for improved dissection of acute leukemia: A recently identified immature myeloid/T-lymphoid subgroup as an example

A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3β as a novel tumor suppressor in lung cancer

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