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Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi‐biomarker pharmacokinetic/pharmacodynamic modelling

British journal of pharmacology, 2018-10, Vol.175 (19), p.3832-3843

2018

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Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Drug discovery today, 2017-06, Vol.22 (6), p.896-911

2017

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Brain Disposition and Catalepsy After Intranasal Delivery of Loxapine: Role of Metabolism in PK/PD of Intranasal CNS Drugs

Pharmaceutical research, 2013-09, Vol.30 (9), p.2368-2384

2013

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Intranasal Delivery—Modification of Drug Metabolism and Brain Disposition

Pharmaceutical research, 2010-07, Vol.27 (7), p.1208-1223

2010

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Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice

Molecular pharmaceutics, 2017-09, Vol.14 (9), p.2908-2916

2017

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Herb–drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats

Journal of ethnopharmacology, 2015-07, Vol.170, p.106-116

2015

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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Pharmaceutical research, 2017-02, Vol.34 (2), p.333-351

2017

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Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

International journal of molecular sciences, 2020-04, Vol.21 (9), p.3158

2020

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Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics

Expert opinion on drug discovery, 2017-12, Vol.12 (12), p.1207-1218

2017

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Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D 2 receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling

British journal of pharmacology, 2018-10, Vol.175 (19), p.3832-3843

2018

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Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

CPT: pharmacometrics and systems pharmacology, 2017-11, Vol.6 (11), p.765-777

2017

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Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS

Journal of pharmaceutical and biomedical analysis, 2012-01, Vol.58 (25), p.83-93

2012

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Alterations in the CNS effects of anti-epileptic drugs by Chinese herbal medicines

Expert opinion on drug metabolism & toxicology, 2014-02, Vol.10 (2), p.249-267

2014

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Development, characterization and application of in situ gel systems for intranasal delivery of tacrine

International journal of pharmaceutics, 2014-07, Vol.468 (1-2), p.272-282

2014

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Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies

Journal of pharmaceutical and biomedical analysis, 2014-08, Vol.97, p.9-23

2014

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Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease

Life sciences (1973), 2018-08, Vol.207, p.428-435

2018

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Comment on Uridine Diphosphate Glucuronosyltransferase Isoform-Dependent Regiospecificity of Glucuronidation of Flavonoids: Applicability of UV Spectrum Shifts in Identification of Glucuronidation Position in Flavones and Flavonols

Journal of agricultural and food chemistry, 2012-05, Vol.60 (17), p.4416-4419

2012

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Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach

European journal of pharmaceutical sciences, 2018-01, Vol.112, p.168-179

2018

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Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

Journal of clinical pharmacology, 2019-05, Vol.59 (5), p.731-747

2019

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Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions

Expert opinion on drug metabolism & toxicology, 2012-07, Vol.8 (7), p.833-854

2012

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Pharmacokinetic Comparison Between the Long-Term Anesthetized, Short-Term Anesthetized and Conscious Rat Models in Nasal Drug Delivery

Pharmaceutical research, 2014-08, Vol.31 (8), p.2107-2123

2014

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Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat

European journal of pharmaceutical sciences, 2018-01, Vol.111, p.514-525

2018

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Intestinal first-pass glucuronidation activities of selected dihydroxyflavones

International journal of pharmaceutics, 2009-01, Vol.366 (1), p.14-20

2009

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Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases

Expert opinion on drug metabolism & toxicology, 2009-11, Vol.5 (11), p.1399-1419

2009

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Identification and disposition of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo

Biopharmaceutics & drug disposition, 2015-11, Vol.36 (8), p.529-551

2015

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Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi‐biomarker pharmacokinetic/pharmacodynamic modelling

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Brain Disposition and Catalepsy After Intranasal Delivery of Loxapine: Role of Metabolism in PK/PD of Intranasal CNS Drugs

Intranasal Delivery—Modification of Drug Metabolism and Brain Disposition

Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice

Herb–drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics

Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D 2 receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling

Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS

Alterations in the CNS effects of anti-epileptic drugs by Chinese herbal medicines

Development, characterization and application of in situ gel systems for intranasal delivery of tacrine

Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies

Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease

Comment on Uridine Diphosphate Glucuronosyltransferase Isoform-Dependent Regiospecificity of Glucuronidation of Flavonoids: Applicability of UV Spectrum Shifts in Identification of Glucuronidation Position in Flavones and Flavonols

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach

Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions

Pharmacokinetic Comparison Between the Long-Term Anesthetized, Short-Term Anesthetized and Conscious Rat Models in Nasal Drug Delivery

Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat

Intestinal first-pass glucuronidation activities of selected dihydroxyflavones

Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases

Identification and disposition of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo

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