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TP53: an oncogene in disguise

Cell death and differentiation, 2015-08, Vol.22 (8), p.1239-1249

2015

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Targeting mutant p53 for efficient cancer therapy

Nature reviews. Cancer, 2018-02, Vol.18 (2), p.89-102

2018

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Understanding cell cycle and cell death regulation provides novel weapons against human diseases

Journal of internal medicine, 2017-05, Vol.281 (5), p.483-495

2017

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Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

Oncogene, 2010-07, Vol.29 (30), p.4245-4252

Wiman, K G

2010

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APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Cell death & disease, 2018-04, Vol.9 (5), p.439-12, Article 439

2018

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Mutant p53 reactivation by small molecules makes its way to the clinic

FEBS letters, 2014-08, Vol.588 (16), p.2622-2627

2014

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Pharmacological reactivation of p53 in the era of precision anticancer medicine

Nature reviews. Clinical oncology, 2024-02, Vol.21 (2), p.106-120

2024

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Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm

Cancer cell, 2007-10, Vol.12 (4), p.303-312

2007

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Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Nature communications, 2017-03, Vol.8 (1), p.14844-14844, Article 14844

2017

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Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

Journal of clinical oncology, 2012-10, Vol.30 (29), p.3633-3639

2012

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PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

Cancer cell, 2009-05, Vol.15 (5), p.376-388

2009

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Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

PloS one, 2023-11, Vol.18 (11), p.e0292468-e0292468

2023

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p53 as a hub in cellular redox regulation and therapeutic target in cancer

Journal of molecular cell biology, 2019-04, Vol.11 (4), p.330-341

2019

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p53 talks to PARP: the increasing complexity of p53-induced cell death

Cell death and differentiation, 2013-11, Vol.20 (11), p.1438-1439

Wiman, K G

2013

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Therapeutic targeting of TP53 nonsense mutations in cancer

Upsala journal of medical sciences, 2024-05, Vol.129, p.e10719-6

2024

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Reactivation of mutant p53: molecular mechanisms and therapeutic potential

Oncogene, 2007-04, Vol.26 (15), p.2243-2254

2007

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The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

Biochemical and biophysical research communications, 2010-05, Vol.396 (1), p.85-89

2010

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Genetic landscape of hepatitis B virus–associated diffuse large B-cell lymphoma

Blood, 2018-06, Vol.131 (24), p.2670-2681

2018

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Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Scientific reports, 2018-08, Vol.8 (1), p.12671-10, Article 12671

2018

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Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

Molecular cell, 2009-02, Vol.33 (4), p.462-471

2009

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APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

Cell death & disease, 2015-06, Vol.6 (6), p.e1794-e1794

2015

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Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s (vol 33, pg 4407, 2014)

ONCOGENE, 2023-01, Vol.42 (9), p.709

2023

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Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Frontiers in oncology, 2016, Vol.6, p.21-21

2016

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Correction to: Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s

Oncogene, 2023-02, Vol.42 (9), p.709-709

2023

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Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

Cell death & disease, 2017-06, Vol.8 (6), p.e2848-e2848

2017

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TP53: an oncogene in disguise

Targeting mutant p53 for efficient cancer therapy

Understanding cell cycle and cell death regulation provides novel weapons against human diseases

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Mutant p53 reactivation by small molecules makes its way to the clinic

Pharmacological reactivation of p53 in the era of precision anticancer medicine

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

p53 as a hub in cellular redox regulation and therapeutic target in cancer

p53 talks to PARP: the increasing complexity of p53-induced cell death

Therapeutic targeting of TP53 nonsense mutations in cancer

Reactivation of mutant p53: molecular mechanisms and therapeutic potential

The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

Genetic landscape of hepatitis B virus–associated diffuse large B-cell lymphoma

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s (vol 33, pg 4407, 2014)

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Correction to: Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

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