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L'Asie-Monde - II : Chroniques sur l'Asie et le Pacifique 2011-2013

Jean-François Sabouret

2015

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VPS34 complexes from a structural perspective

Journal of lipid research, 2019-02, Vol.60 (2), p.229-241

2019

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Activation of GCN2 by the ribosomal P-stalk

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (11), p.4946-4954

2019

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Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Science (American Association for the Advancement of Science), 2015-10, Vol.350 (6257), p.178-178

2015

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Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)

Proceedings of the National Academy of Sciences - PNAS, 2012-09, Vol.109 (38), p.15259-15264

2012

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Evan Pugh’s Penn State: America’s Model Agricultural College

Williams, Roger L

1, 2018

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The origins of federal support for higher education: George W. Atherton and the Land-Grant College Movement

Williams, Roger L

1, 1991

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The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

eLife, 2019-11, Vol.8

2019

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Frederick Watts and the Founding of Penn State

Williams, Roger L

1, 2021

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Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

Molecular cell, 2011-03, Vol.41 (5), p.567-578

2011

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Tor forms a dimer through an N-terminal helical solenoid with a complex topology

Nature communications, 2016-04, Vol.7 (1), p.11016-11016, Article 11016

2016

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5‑(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology

Journal of medicinal chemistry, 2017-09, Vol.60 (17), p.7524-7538

2017

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Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

Science signaling, 2011-10, Vol.4 (195), p.re2

2011

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A Role for the ESCRT System in Cell Division in Archaea

Science (American Association for the Advancement of Science), 2008-12, Vol.322 (5908), p.1710-1713

2008

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The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

Biochemical journal, 2016-01, Vol.473 (2), p.135-144

2016

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Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

Biophysical journal, 2016-04, Vol.110 (8), p.1811-1825

2016

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Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Nature communications, 2017-03, Vol.8 (1), p.14683-14683, Article 14683

2017

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Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

Nature communications, 2021-03, Vol.12 (1), p.1564-1564, Article 1564

2021

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Nature chemical biology, 2008-11, Vol.4 (11), p.691-699

2008

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Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Structure (London), 2011-08, Vol.19 (8), p.1127-1137

2011

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Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

Science (American Association for the Advancement of Science), 2007-07, Vol.317 (5835), p.239-242

2007

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Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

Nature communications, 2019-09, Vol.10 (1), p.4364-12, Article 4364

2019

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Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

eLife, 2020-06, Vol.9

2020

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Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

Nature, 2007-10, Vol.449 (7163), p.735-739

2007

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Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

Cell reports (Cambridge), 2016-07, Vol.16 (3), p.839-850

2016

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L'Asie-Monde - II : Chroniques sur l'Asie et le Pacifique 2011-2013

VPS34 complexes from a structural perspective

Activation of GCN2 by the ribosomal P-stalk

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)

Evan Pugh’s Penn State: America’s Model Agricultural College

The origins of federal support for higher education: George W. Atherton and the Land-Grant College Movement

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

Frederick Watts and the Founding of Penn State

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

Tor forms a dimer through an N-terminal helical solenoid with a complex topology

5‑(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

A Role for the ESCRT System in Cell Division in Archaea

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

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