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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Nature communications, 2019-05, Vol.10 (1), p.2087-12, Article 2087

2019

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MAP3K11/GDF15 axis is a critical driver of cancer cachexia

Journal of cachexia, sarcopenia and muscle, 2016-09, Vol.7 (4), p.467-482

2016

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Cancer cell, 2002-09, Vol.2 (3), p.183-192

2002

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GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Cancer research (Chicago, Ill.), 2010-10, Vol.70 (19), p.7630-7639

2010

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A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

Developmental cell, 2002, Vol.2 (1), p.55-67

2002

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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Genes & development, 2000-08, Vol.14 (16), p.2060-2071

2000

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Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

Science (American Association for the Advancement of Science), 2000-12, Vol.290 (5497), p.1761-1765

2000

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Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models

Clinical cancer research, 2015-03, Vol.21 (5), p.1106-1114

2015

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BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

Molecular cell, 2001-09, Vol.8 (3), p.705-711

2001

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BCL-2, BCL-X L Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

Molecular cell, 2001-09, Vol.8 (3), p.705-711

2001

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Abstract 3589: Preclinical evaluation of mesothelin-specific T cell receptor (TCR) fusion constructs (TRuC™s) utilizing the signaling power of the complete TCR complex: A new opportunity for solid tumor therapy

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3589-3589

2018

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Identification of the neurotrophic factor sequence of prosaposin

The FASEB journal, 1995-05, Vol.9 (8), p.681-685

1995

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Abstract 3584: Characterization of a novel class of engineered (TCR) fusion constructs (TRuCTMs) aimed to treat solid tumors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3584-3584

2018

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Solution Structure of Human Saposin C: pH-Dependent Interaction with Phospholipid Vesicles

Biochemistry (Easton), 2003-12, Vol.42 (50), p.14729-14740

2003

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Abstract 1153: Effective treatment of cancer associated cachexia by AV-380, a GDF15 inhibitory antibody

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1153-1153

2015

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23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity

Molecular cancer therapeutics, 2015-08, Vol.14 (8), p.1858-1867

2015

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Structural Basis of an Embryonically Lethal Single Ala → Thr Mutation in the vnd/NK-2 Homeodomain

Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (13), p.7412-7416

1998

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Abstract 2509: AV-203, a humanized ERBB3 inhibitory antibody inhibits ligand-dependent and ligand-independent ERBB3 signaling in vitro and in vivo

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2509-2509

2012

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Abstract A5: Tivozanib, a selective VEGFR TKI, potently blocks angiogenesis and growth in tumors that express a high level of VEGF-C and are refractory to VEGF-A blockade

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A5-A5

2011

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Abstract 642: Novel EGFR inhibitory antibodies directed against EGFR mutants with potentially reduced toxicity

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.642-642

2011

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Abstract 628: Functional characterization of a diverse set of ERBB3 inhibitory antibodies

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.628-628

2011

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Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2206-2210

2008

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On-Line Microdialysis for Mass Spectrometry

BioTechniques, 1998-05, Vol.24 (5), p.712-716

1998

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Abstract 4586: Essential role of fibroblast growth factor receptor 2 (FGFR2) in tumorigenesis of human cancers with activated FGFR2 signaling demonstrated by functional blocking antibodies

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4586-4586

2011

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Abstract 644: Anti-tumor activities of antibodies targeting the RON receptor and a biomarker of response

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.644-644

2011

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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

MAP3K11/GDF15 axis is a critical driver of cancer cachexia

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

BCL-2, BCL-X L Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

Abstract 3589: Preclinical evaluation of mesothelin-specific T cell receptor (TCR) fusion constructs (TRuC™s) utilizing the signaling power of the complete TCR complex: A new opportunity for solid tumor therapy

Identification of the neurotrophic factor sequence of prosaposin

Abstract 3584: Characterization of a novel class of engineered (TCR) fusion constructs (TRuCTMs) aimed to treat solid tumors

Solution Structure of Human Saposin C: pH-Dependent Interaction with Phospholipid Vesicles

Abstract 1153: Effective treatment of cancer associated cachexia by AV-380, a GDF15 inhibitory antibody

23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity

Structural Basis of an Embryonically Lethal Single Ala → Thr Mutation in the vnd/NK-2 Homeodomain

Abstract 2509: AV-203, a humanized ERBB3 inhibitory antibody inhibits ligand-dependent and ligand-independent ERBB3 signaling in vitro and in vivo

Abstract A5: Tivozanib, a selective VEGFR TKI, potently blocks angiogenesis and growth in tumors that express a high level of VEGF-C and are refractory to VEGF-A blockade

Abstract 642: Novel EGFR inhibitory antibodies directed against EGFR mutants with potentially reduced toxicity

Abstract 628: Functional characterization of a diverse set of ERBB3 inhibitory antibodies

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

On-Line Microdialysis for Mass Spectrometry

Abstract 4586: Essential role of fibroblast growth factor receptor 2 (FGFR2) in tumorigenesis of human cancers with activated FGFR2 signaling demonstrated by functional blocking antibodies

Abstract 644: Anti-tumor activities of antibodies targeting the RON receptor and a biomarker of response

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