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International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Pharmacological reviews, 2017-04, Vol.69 (2), p.93-139

2017

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Discovery of a Potent and Selective human AC2 inhibitor based on 7-Deazapurine Analogues of Adefovir

Bioorganic & medicinal chemistry, 2023-11, Vol.95, p.117508-117508, Article 117508

2023

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Editorial: Adenylyl cyclase isoforms as potential drug targets

Frontiers in pharmacology, 2022-12, Vol.13, p.1098240-1098240

2022

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A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

Nature communications, 2024-09, Vol.15 (1), p.7684-21, Article 7684

2024

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Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors

PLoS neglected tropical diseases, 2015-03, Vol.9 (3), p.e0003515

2015

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Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Frontiers in pharmacology, 2022-09, Vol.13, p.977742

2022

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Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice

Frontiers in pharmacology, 2022-09, Vol.13, p.937741-937741

2022

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Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers

ACS nano, 2014-04, Vol.8 (4), p.3347-3356

2014

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Fluorescent and Bioluminescent Protein-Fragment Complementation Assays in the Study of G Protein-Coupled Receptor Oligomerization and Signaling

Molecular pharmacology, 2009-04, Vol.75 (4), p.733-739

2009

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A “Genome-to-Lead” Approach for Insecticide Discovery: Pharmacological Characterization and Screening of Aedes aegypti D1-like Dopamine Receptors

PLoS neglected tropical diseases, 2012-01, Vol.6 (1), p.e1478

2012

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Molecular mechanisms for heterologous sensitization of adenylate cyclase

The Journal of pharmacology and experimental therapeutics, 2002-07, Vol.302 (1), p.1-7

Watts, Val J

2002

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Physiological roles of mammalian transmembrane adenylyl cyclase isoforms

Physiological reviews, 2022-04, Vol.102 (2), p.815-857

2022

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Pyrazolo-Pyrimidinones with Improved Solubility and Selective Inhibition of Adenylyl Cyclase Type 1 Activity for Treatment of Inflammatory Pain

Journal of medicinal chemistry, 2024-10

2024

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Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain

Neuropsychopharmacology (New York, N.Y.), 2018-01, Vol.43 (1), p.215-216

Watts, Val J

2018

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Biochemical pharmacology of adenylyl cyclases in cancer

Biochemical pharmacology, 2024-10, Vol.228, p.116160, Article 116160

2024

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Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening

Cells (Basel, Switzerland), 2019-11, Vol.8 (11), p.1468

2019

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Comparative pharmacological characterization of D1-like dopamine receptors from Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages

Parasites & vectors, 2016-04, Vol.9 (192), p.192-192, Article 192

2016

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Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9

Molecular pharmacology, 2019-04, Vol.95 (4), p.349-360

2019

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Novel regulatory properties of human type 9 adenylate cyclase

The Journal of pharmacology and experimental therapeutics, 2004-07, Vol.310 (1), p.108-115

2004

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Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia

Nature structural & molecular biology, 2024-08, Vol.31 (8), p.1189-1197

2024

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Molecular and pharmacological characterization of two D1-like dopamine receptors in the Lyme disease vector, Ixodes scapularis

Insect biochemistry and molecular biology, 2011-08, Vol.41 (8), p.563-571

2011

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The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice

Behavioural brain research, 2021-02, Vol.399, p.113051-113051, Article 113051

2021

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Genomics, GPCRs and new targets for the control of insect pests and vectors

Current opinion in insect science, 2018-12, Vol.30, p.99-106

2018

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Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling

Molecular and cellular endocrinology, 2011-01, Vol.331 (2), p.185-193

2011

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A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling

Molecular pharmacology, 2018-09, Vol.94 (3), p.963-972

2018

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International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Discovery of a Potent and Selective human AC2 inhibitor based on 7-Deazapurine Analogues of Adefovir

Editorial: Adenylyl cyclase isoforms as potential drug targets

A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice

Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers

Fluorescent and Bioluminescent Protein-Fragment Complementation Assays in the Study of G Protein-Coupled Receptor Oligomerization and Signaling

A “Genome-to-Lead” Approach for Insecticide Discovery: Pharmacological Characterization and Screening of Aedes aegypti D1-like Dopamine Receptors

Molecular mechanisms for heterologous sensitization of adenylate cyclase

Physiological roles of mammalian transmembrane adenylyl cyclase isoforms

Pyrazolo-Pyrimidinones with Improved Solubility and Selective Inhibition of Adenylyl Cyclase Type 1 Activity for Treatment of Inflammatory Pain

Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain

Biochemical pharmacology of adenylyl cyclases in cancer

Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening

Comparative pharmacological characterization of D1-like dopamine receptors from Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages

Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9

Novel regulatory properties of human type 9 adenylate cyclase

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia

Molecular and pharmacological characterization of two D1-like dopamine receptors in the Lyme disease vector, Ixodes scapularis

The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice

Genomics, GPCRs and new targets for the control of insect pests and vectors

Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling

A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling

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