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Residue 6.43 defines receptor function in class F GPCRs

Nature communications, 2021-06, Vol.12 (1), p.3919-3919, Article 3919

2021

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Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment

Nature communications, 2024-02, Vol.15 (1), p.1831-1831

2024

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Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs

Cell research, 2021-12, Vol.31 (12), p.1311-1314

2021

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eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

The Journal of biological chemistry, 2020-06, Vol.295 (26), p.8759-8774

2020

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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11695-11708

2021

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A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics

Communications biology, 2018-01, Vol.1 (1), p.105-105, Article 105

2018

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Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists

ACS sensors, 2020-06, Vol.5 (6), p.1734-1742

2020

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Optical control of the β2-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol

iScience, 2022-09, Vol.25 (9), p.104882-104882, Article 104882

2022

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Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors

Science signaling, 2021-09, Vol.14 (699), p.eabf1653

2021

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Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors

Biosensors & bioelectronics, 2021-04, Vol.177, p.112948-112948, Article 112948

2021

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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H 3 Receptor

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11695-11708

2021

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WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction

Science signaling, 2023-04, Vol.16 (779), p.eabo4974

2023

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Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation

Pharmacology of the WNT Signaling System, p.101-115

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Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias

The Journal of biological chemistry, 2022-09, Vol.298 (9), p.102328-102328, Article 102328

2022

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Functional modulation of PTH1R activation and signaling by RAMP2

Proceedings of the National Academy of Sciences - PNAS, 2022-08, Vol.119 (32), p.e2122037119-e2122037119

2022

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A guide to adhesion GPCR research

The FEBS journal, 2022-12, Vol.289 (24), p.7610-7630

2022

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Fluorescent Tools for the Imaging of Dopamine D 2 -Like Receptors

Chembiochem : a European journal of chemical biology, 2024-01, Vol.25 (2), p.e202300659

2024

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Shedding Light on the D 1 -Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D 1 and D 5 Receptors

Chembiochem : a European journal of chemical biology, 2024-01, Vol.25 (2), p.e202300658

2024

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The dark sides of the GPCR tree - research progress on understudied GPCRs

British journal of pharmacology, 2024-02

2024

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Shedding Light on the D1‐Like Receptors: A Fluorescence‐Based Toolbox for Visualization of the D1 and D5 Receptors

Chembiochem : a European journal of chemical biology, 2024-01, Vol.25 (2), p.e202300658-n/a

2024

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Fluorescent Tools for the Imaging of Dopamine D2‐Like Receptors

Chembiochem : a European journal of chemical biology, 2024-01, Vol.25 (2), p.e202300659-n/a

2024

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A virtual library of small molecules mimicking dipeptides

Archiv der Pharmazie (Weinheim), 2024-02, p.e2300636-e2300636

2024

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Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

Science advances, 2021-11, Vol.7 (46), p.eabj7917-eabj7917

2021

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Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment

Nature communications, 2024-02, Vol.15 (1), p.1831

2024

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Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s

Cell research, 2021-12, Vol.31 (12), p.1311

2021

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Residue 6.43 defines receptor function in class F GPCRs

Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor

A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics

Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists

Optical control of the β2-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol

Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors

Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors

A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H 3 Receptor

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction

Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation

Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias

Functional modulation of PTH1R activation and signaling by RAMP2

A guide to adhesion GPCR research

Fluorescent Tools for the Imaging of Dopamine D 2 -Like Receptors

Shedding Light on the D 1 -Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D 1 and D 5 Receptors

The dark sides of the GPCR tree - research progress on understudied GPCRs

Shedding Light on the D1‐Like Receptors: A Fluorescence‐Based Toolbox for Visualization of the D1 and D5 Receptors

Fluorescent Tools for the Imaging of Dopamine D2‐Like Receptors

A virtual library of small molecules mimicking dipeptides

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s

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