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Comparative performance evaluation and systematic screening of solvents in a range of Grignard reactions

Green chemistry : an international journal and green chemistry resource : GC, 2013-01, Vol.15 (7), p.1880-1888

2013

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Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP)

ChemMedChem, 2016-01, Vol.11 (2), p.217-233

2016

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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8597-8612

2018

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Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors: From the Active Site to the Second Phosphotyrosine Binding Site

Journal of medicinal chemistry, 2007-09, Vol.50 (19), p.4681-4698

2007

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Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation

Cell chemical biology, 2020-12, Vol.27 (12), p.1500-1509.e13

2020

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Asymmetric Ni(II)/Cr(II)-Mediated Coupling Reaction: Catalytic Process

Organic letters, 2002-12, Vol.4 (25), p.4435-4438

2002

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Oxidative Palladium Catalysis in SNAr Reactions Leading to Heteroaryl Ethers from Pyridotriazol-1-yloxy Heterocycles with Aryl Boronic Acids

Journal of the American Chemical Society, 2009-04, Vol.131 (12), p.4174-4175

2009

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Asymmetric Ni(II)/Cr(II)-Mediated Coupling Reaction: Stoichiometric Process

Organic letters, 2002-12, Vol.4 (25), p.4431-4434

2002

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Phosphonium-mediated cyclization of N-(2-aminophenyl)thioureas: efficient synthesis of 2-aminobenzimidazoles

Tetrahedron letters, 2011-08, Vol.52 (32), p.4149-4152

2011

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Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1

Bioorganic & medicinal chemistry, 2020-05, Vol.28 (10), p.115481-115481, Article 115481

2020

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Efficient Phosphonium-Mediated Synthesis of 2-Amino-1,3,4-oxadiazoles

Organic letters, 2008-05, Vol.10 (9), p.1755-1758

2008

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Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes

ACS medicinal chemistry letters, 2013-01, Vol.4 (1), p.118-123

2013

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The Scope and Mechanism of Phosphonium-Mediated SNAr Reactions in Heterocyclic Amides and Ureas

Journal of organic chemistry, 2007-12, Vol.72 (26), p.10194-10210

2007

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An Efficient Direct Amination of Cyclic Amides and Cyclic Ureas

Organic letters, 2006-05, Vol.8 (11), p.2425-2428

2006

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Preparation of α-Haloacrylate Derivatives via Dimethyl Sulfoxide-Mediated Selective Dehydrohalogenation

Organic letters, 2007-10, Vol.9 (22), p.4607-4610

2007

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N-Arylation of a hindered indoline as a route to 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-3-yl)acetic acid derivatives

Tetrahedron letters, 2011-11, Vol.52 (48), p.6317-6320

2011

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Efficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model

Journal of medicinal chemistry, 2009-09, Vol.52 (17), p.5449-5461

2009

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Synthesis of Potent and Orally Efficacious 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor HSD-016

Journal of organic chemistry, 2011-09, Vol.76 (17), p.7048-7055

2011

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Heteroaryl Ethers by Oxidative Palladium Catalysis of Pyridotriazol-1-yloxy Pyrimidines with Arylboronic Acids

Organic letters, 2009-06, Vol.11 (12), p.2511-2514

2009

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Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase

The Journal of biological chemistry, 2012-03, Vol.287 (10), p.7717-7727

2012

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Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4941-4945

2006

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Hydrogen peroxide mediated formation of heteroaryl ethers from pyridotriazol-1-yloxy heterocycles and arylboronic acids

Tetrahedron letters, 2009-10, Vol.50 (41), p.5733-5736

2009

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Intramolecular Inverse-Electron-Demand Diels−Alder Reactions of Imidazoles with 1,2,4-Triazines: A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles

Journal of organic chemistry, 2004-10, Vol.69 (21), p.7171-7182

2004

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Piperazine Sulfonamides as Potent, Selective, and Orally Available 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors with Efficacy in the Rat Cortisone-Induced Hyperinsulinemia Model

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4068-4071

2008

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Comparative performance evaluation and systematic screening of solvents in a range of Grignard reactions

Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP)

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors: From the Active Site to the Second Phosphotyrosine Binding Site

Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation

Asymmetric Ni(II)/Cr(II)-Mediated Coupling Reaction: Catalytic Process

Oxidative Palladium Catalysis in SNAr Reactions Leading to Heteroaryl Ethers from Pyridotriazol-1-yloxy Heterocycles with Aryl Boronic Acids

Asymmetric Ni(II)/Cr(II)-Mediated Coupling Reaction: Stoichiometric Process

Phosphonium-mediated cyclization of N-(2-aminophenyl)thioureas: efficient synthesis of 2-aminobenzimidazoles

Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1

Efficient Phosphonium-Mediated Synthesis of 2-Amino-1,3,4-oxadiazoles

Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes

The Scope and Mechanism of Phosphonium-Mediated SNAr Reactions in Heterocyclic Amides and Ureas

An Efficient Direct Amination of Cyclic Amides and Cyclic Ureas

Preparation of α-Haloacrylate Derivatives via Dimethyl Sulfoxide-Mediated Selective Dehydrohalogenation

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

N-Arylation of a hindered indoline as a route to 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-3-yl)acetic acid derivatives

Efficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model

Synthesis of Potent and Orally Efficacious 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor HSD-016

Heteroaryl Ethers by Oxidative Palladium Catalysis of Pyridotriazol-1-yloxy Pyrimidines with Arylboronic Acids

Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase

Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48

Hydrogen peroxide mediated formation of heteroaryl ethers from pyridotriazol-1-yloxy heterocycles and arylboronic acids

Intramolecular Inverse-Electron-Demand Diels−Alder Reactions of Imidazoles with 1,2,4-Triazines: A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles

Piperazine Sulfonamides as Potent, Selective, and Orally Available 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors with Efficacy in the Rat Cortisone-Induced Hyperinsulinemia Model

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