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Stem cell models of Alzheimer's disease: progress and challenges

Alzheimer's research & therapy, 2017-06, Vol.9 (1), p.42-42, Article 42

2017

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C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis

Lancet neurology, 2015-03, Vol.14 (3), p.291-301

2015

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Neuronal activity enhances tau propagation and tau pathology in vivo

Nature neuroscience, 2016-08, Vol.19 (8), p.1085

2016

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Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

Cell reports (Cambridge), 2019-01, Vol.26 (3), p.582-593.e5

2019

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Modelling neurodegenerative disease using brain organoids

Seminars in cell & developmental biology, 2021-03, Vol.111, p.60-66

Wray, Selina

2021

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Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies

Biomolecules, 2016-01, Vol.6 (1), p.6

2016

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Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

Cell reports (Cambridge), 2021-01, Vol.34 (2), p.108615-108615, Article 108615

2021

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Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia

Journal of cell science, 2020-05, Vol.133 (10)

2020

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Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

Redox biology, 2017-08, Vol.12, p.410-422

2017

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Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

Scientific reports, 2017-08, Vol.7 (1), p.9003-11, Article 9003

2017

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Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Cell reports (Cambridge), 2017-05, Vol.19 (9), p.1739-1749

2017

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MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

Human molecular genetics, 2012-09, Vol.21 (18), p.4094-4103

2012

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Editorial: Mechanisms of Action in Neurodegenerative Proteinopathies

Frontiers in neuroscience, 2022-06, Vol.16, p.968994-968994

2022

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Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia

Cell death & disease, 2021-07, Vol.12 (8), p.716-716, Article 716

2021

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Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis

The Journal of biological chemistry, 2007-08, Vol.282 (32), p.23645-23654

2007

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Knockdown of Amyloid Precursor Protein: Biological Consequences and Clinical Opportunities

Frontiers in neuroscience, 2022-03, Vol.16, p.835645-835645

2022

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Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

Scientific reports, 2016-07, Vol.6 (1), p.29200-29200, Article 29200

2016

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Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

Neuron (Cambridge, Mass.), 2013-04, Vol.78 (1), p.57-64

2013

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Tau cleavage and tau aggregation in neurodegenerative disease

Biochemical Society transactions, 2010-08, Vol.38 (4), p.1016

2010

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iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease

PloS one, 2017-09, Vol.12 (9), p.e0184104-e0184104

2017

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Computational modelling of pathogenic protein spread in neurodegenerative diseases

PloS one, 2018-02, Vol.13 (2), p.e0192518

2018

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SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases

Nature reviews. Neurology, 2019-07, Vol.15 (7), p.419

2019

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Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant

Stem cell research, 2024-10, Vol.80, p.103503, Article 103503

2024

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Stem cell models of Alzheimer's disease: progress and challenges

C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis

Neuronal activity enhances tau propagation and tau pathology in vivo

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

Modelling neurodegenerative disease using brain organoids

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

Editorial: Mechanisms of Action in Neurodegenerative Proteinopathies

Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia

Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis

Knockdown of Amyloid Precursor Protein: Biological Consequences and Clinical Opportunities

Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

Tau cleavage and tau aggregation in neurodegenerative disease

iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease

Computational modelling of pathogenic protein spread in neurodegenerative diseases

SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases

Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant

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