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mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor

Clinical cancer research, 2009-03, Vol.15 (5), p.1612-1622

2009

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VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer

Molecular cancer therapeutics, 2013-02, Vol.12 (2), p.151-161

2013

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The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

Angiogenesis (London), 2010-09, Vol.13 (3), p.259-267

2010

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Structure-based design of aliskiren, a novel orally effective renin inhibitor

Biochemical and biophysical research communications, 2003-09, Vol.308 (4), p.698-705

2003

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Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

Cancer cell, 2002-04, Vol.1 (3), p.257-267

2002

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Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish

Nature chemical biology, 2006-05, Vol.2 (5), p.265-273

2006

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Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Journal of medicinal chemistry, 2007-10, Vol.50 (20), p.4832-4844

2007

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Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization

The American journal of pathology, 2000-02, Vol.156 (2), p.697-707

2000

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Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor

Arteriosclerosis, thrombosis, and vascular biology, 2003-01, Vol.23 (1), p.69

2003

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Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor

The American journal of pathology, 1999-06, Vol.154 (6), p.1743-1753

1999

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Therapies directed at vascular endothelial growth factor

Expert opinion on investigational drugs, 2002-12, Vol.11 (12), p.1715-1736

2002

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Phase I and Pharmacological Study of the Oral Matrix Metalloproteinase Inhibitor, MMI270 (CGS27023A), in Patients with Advanced Solid Cancer

Clinical cancer research, 2001-07, Vol.7 (7), p.1912-1922

2001

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Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4694-4720

2011

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Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors

Cancer and metastasis reviews, 1999, Vol.18 (4), p.473-481

1999

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SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis

The Journal of immunology (1950), 2012-10, Vol.189 (8), p.4123-4134

2012

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PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration

Cancer research (Chicago, Ill.), 2000-04, Vol.60 (8), p.2178-2189

2000

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Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats

Journal of hypertension, 2005-02, Vol.23 (2), p.417-426

2005

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Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond

Journal of medicinal chemistry, 1989-07, Vol.32 (7), p.1652-1661

1989

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The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4863-4867

2009

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Novel 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin

Journal of medicinal chemistry, 2007-10, Vol.50 (20), p.4818-4831

2007

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2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2880-2884

2012

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mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor

VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

Structure-based design of aliskiren, a novel orally effective renin inhibitor

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization

Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor

Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor

Therapies directed at vascular endothelial growth factor

Phase I and Pharmacological Study of the Oral Matrix Metalloproteinase Inhibitor, MMI270 (CGS27023A), in Patients with Advanced Solid Cancer

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors

SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration

Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats

Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond

The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin

Novel 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin

2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1

New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis

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