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Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease

Current medicinal chemistry, 2015-01, Vol.22 (3), p.373

2015

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Structure-based search for new inhibitors of cholinesterases

International journal of molecular sciences, 2013-03, Vol.14 (3), p.5608-5632

2013

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Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive

Seminars in liver disease, 2008-11, Vol.28 (4), p.386

2008

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Dual Inhibitors of Amyloid‑β and Tau Aggregation with Amyloid‑β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents

ACS chemical neuroscience, 2021-06, Vol.12 (11), p.2057-2068

2021

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Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Scientific reports, 2016-12, Vol.6 (1), p.39495-39495, Article 39495

2016

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Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)6 or W(CO)6

Journal of organic chemistry, 2011-02, Vol.76 (3), p.978-981

2011

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Non‐syndromic anophthalmia/microphthalmia can be caused by a PORCN variant inherited in X‐linked recessive manner

American journal of medical genetics. Part A, 2021-01, Vol.185 (1), p.250-255

2021

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Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis: A Multicenter Validation Study

Hepatology (Baltimore, Md.), 2009-10, Vol.50 (4), p.1072-1078

2009

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Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future

Hepatology (Baltimore, Md.), 2007-08, Vol.46 (2), p.582-589

2007

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Ophthalmological symptoms in children with intracranial cysts

Scientific reports, 2017-10, Vol.7 (1), p.13630-5, Article 13630

2017

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Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

The American journal of gastroenterology, 2008-06, Vol.103 (6), p.1372-1379

2008

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Discovery of Novel pERK1/2- or β‑Arrestin-Preferring 5‑HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10946-10971

2020

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Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents

ACS chemical neuroscience, 2018-05, Vol.9 (5), p.1074-1094

2018

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Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

European journal of medicinal chemistry, 2017-01, Vol.125, p.676-695

2017

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1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease

European journal of medicinal chemistry, 2020-02, Vol.187, p.111916-111916, Article 111916

2020

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Bacterial type I signal peptidase inhibitors - Optimized hits from nature

European journal of medicinal chemistry, 2022-08, Vol.238, p.114490-114490, Article 114490

2022

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In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease

Hepatology (Baltimore, Md.), 2006-07, Vol.44 (1), p.27-33

2006

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Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer’s Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors

Molecules (Basel, Switzerland), 2024-06, Vol.29 (11), p.2616

2024

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Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer’s Disease

ACS chemical neuroscience, 2018-05, Vol.9 (5), p.1195-1214

2018

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Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease

Bioorganic & medicinal chemistry, 2023-06, Vol.88-89, p.117333-117333, Article 117333

2023

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Multitargeting Histamine H3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives

Molecules (Basel, Switzerland), 2023-03, Vol.28 (5), p.2349

2023

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Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.4964-4976

2011

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Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency

Pediatrics (Evanston), 2015-11, Vol.136 (5), p.e1366

2015

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Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions

Bioorganic & medicinal chemistry, 2023-12, Vol.96, p.117535-117535, Article 117535

2023

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Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease

Structure-based search for new inhibitors of cholinesterases

Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive

Dual Inhibitors of Amyloid‑β and Tau Aggregation with Amyloid‑β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents

Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)6 or W(CO)6

Non‐syndromic anophthalmia/microphthalmia can be caused by a PORCN variant inherited in X‐linked recessive manner

Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis: A Multicenter Validation Study

Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future

Ophthalmological symptoms in children with intracranial cysts

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

Discovery of Novel pERK1/2- or β‑Arrestin-Preferring 5‑HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents

Novel Aryloxyethyl Derivatives of 1‑(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5‑HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease

Bacterial type I signal peptidase inhibitors - Optimized hits from nature

In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer’s Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors

Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer’s Disease

Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease

Multitargeting Histamine H3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives

Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase

Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency

Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions

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