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A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations

PloS one, 2012-07, Vol.7 (7), p.e42001-e42001

2012

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Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer

Nature communications, 2021-06, Vol.12 (1), p.3697-12, Article 3697

2021

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Author Correction: Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer

Nature communications, 2022-09, Vol.13 (1), p.5579-5579, Article 5579

2022

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Telomerase catalytic subunit homologs from fission yeast and human

Science (American Association for the Advancement of Science), 1997-08, Vol.277 (5328), p.955-959

1997

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Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry

International Journal of Cell Biology, 2015, Vol.2015 (2015), p.244-251

2015

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The RNA Component of Human Telomerase

Science (American Association for the Advancement of Science), 1995-09, Vol.269 (5228), p.1236-1241

1995

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Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer

Oncogene, 2019-05, Vol.38 (21), p.4125-4141

2019

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.2005-2024

2016

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Navigating the Regulatory Landscape to Develop Pediatric Oncology Drugs: Expert Opinion Recommendations

Paediatric drugs, 2021-07, Vol.23 (4), p.381-394

2021

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Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Chembiochem : a European journal of chemical biology, 2016-10, Vol.17 (20), p.1925-1930

2016

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Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer

Nature cancer, 2022-06, Vol.3 (6), p.710-722

2022

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Longitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer

Genome medicine, 2023-07, Vol.15 (1), p.55-55, Article 55

2023

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Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation

Clinical cancer research, 2013-06, Vol.19 (11), p.2929-2940

2013

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Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR

Science signaling, 2014-11, Vol.7 (351), p.ra107

2014

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Science (American Association for the Advancement of Science), 1994-12, Vol.266 (5193), p.2011-2015

1994

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Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

Cancer cell, 2021-10, Vol.39 (10), p.1404-1421.e11

2021

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Abstract PD2-08: Serial genomic profiling reveals molecular mechanisms of breast cancer resistance to palbociclib

Cancer research (Chicago, Ill.), 2022-02, Vol.82 (4_Supplement), p.PD2-08-PD2-08

2022

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Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)

Methods in cell science, 1995-03, Vol.17 (1), p.1-15

1995

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IGFBP-5 Metabolism Is Disrupted in the Rat Medial Meniscal Tear Model of Osteoarthritis

Cartilage, 2010-01, Vol.1 (1), p.43-54

2010

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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

Nature genetics, 1997-12, Vol.17 (4), p.498-502

1997

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Reconstitution of telomerase activity utilizing human catalytic subunit expressed in insect cells

Biochemical and biophysical research communications, 2002-10, Vol.298 (1), p.144-150

2002

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Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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Abstract 2594: Characterization of a novel irreversible third generation EGFR TKI that targets T790M-mediated resistant EGFR-mutant NSCLC while sparing wild type EGFR

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2594-2594

2015

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A tandemly–oriented late gene cluster within the vaccinia virus genome

Nucleic acids research, 1986-04, Vol.14 (7), p.3003-3016

1986

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A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations

Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer

Author Correction: Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer

Telomerase catalytic subunit homologs from fission yeast and human

Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry

The RNA Component of Human Telomerase

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer

Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Navigating the Regulatory Landscape to Develop Pediatric Oncology Drugs: Expert Opinion Recommendations

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer

Longitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer

Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation

Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

Abstract PD2-08: Serial genomic profiling reveals molecular mechanisms of breast cancer resistance to palbociclib

Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)

IGFBP-5 Metabolism Is Disrupted in the Rat Medial Meniscal Tear Model of Osteoarthritis

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

Reconstitution of telomerase activity utilizing human catalytic subunit expressed in insect cells

Abstract 2594: Characterization of a novel irreversible third generation EGFR TKI that targets T790M-mediated resistant EGFR-mutant NSCLC while sparing wild type EGFR

A tandemly–oriented late gene cluster within the vaccinia virus genome

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