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Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy

Circulation. Heart failure, 2015-01, Vol.8 (1), p.71-78

2015

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Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

Hypertension (Dallas, Tex. 1979), 2008-07, Vol.52 (1), p.130-136

2008

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Direct Renin Inhibitors as a New Therapy for Hypertension

Journal of medicinal chemistry, 2010-11, Vol.53 (21), p.7490-7520

2010

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The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey

Toxicology and applied pharmacology, 2017-05, Vol.323, p.53-65

2017

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Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats

Hypertension (Dallas, Tex. 1979), 2005-09, Vol.46 (3), p.569-576

2005

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Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

European heart journal, 2008-09, Vol.29 (17), p.2171-2179

2008

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Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage

Circulation (New York, N.Y.), 2005-06, Vol.111 (23), p.3087-3094

2005

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Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats

Journal of hypertension, 2005-02, Vol.23 (2), p.417-426

2005

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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

The Journal of pharmacology and experimental therapeutics, 2017-02, Vol.360 (2), p.356

2017

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The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2207-2217

2013

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trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (8), p.1787-1791

2015

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A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3 –P1 Pharmacophore

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2196-2206

2013

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Beneficial Effects of Combined Benazepril-Amlodipine on Cardiac Nitric Oxide, cGMP, and TNF-α Production After Cardiac Ischemia

Journal of cardiovascular pharmacology, 2006-05, Vol.47 (5), p.636-642

2006

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Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors

ACS medicinal chemistry letters, 2014-07, Vol.5 (7), p.787-792

2014

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Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP

Journal of hypertension, 2008-02, Vol.26 (2), p.322-333

2008

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Efficacy and safety of sacubitril/valsartan compared with olmesartan in Asian patients with essential hypertension: A randomized, double‐blind, 8‐week study

The journal of clinical hypertension (Greenwich, Conn.), 2019-01, Vol.21 (1), p.67-76

2019

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Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

The Journal of biological chemistry, 1997-08, Vol.272 (32), p.19943-19950

1997

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Renin inhibition with aliskiren : where are we now, and where are we going?

Journal of hypertension, 2006-02, Vol.24 (2), p.243-256

2006

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Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats

American journal of hypertension, 2005-04, Vol.18 (4), p.544-548

2005

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P-664: Combined benazepril-amlodipine treatment improves cardiac nitric oxide and cGMP production post cardiac ischemia

American journal of hypertension, 2005-05, Vol.18 (S4), p.249A-250A

2005

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P-651: Combined benazepril-amlodipine treatment reduces cardiac TNFa production post cardiac ischemia

American journal of hypertension, 2005-05, Vol.18 (S4), p.244A-244A

2005

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Effects of Valsartan and Valeryl 4-Hydroxy Valsartan on Human Platelets: A Possible Additional Mechanism for Clinical Benefits

Journal of cardiovascular pharmacology, 2004-05, Vol.43 (5), p.677-684

2004

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Differences in AT2-receptor stimulation between AT1-receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP

Journal of hypertension, 2002-06, Vol.20 (6), p.1157-1163

2002

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A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model

American journal of physiology. Regulatory, integrative and comparative physiology, 2014-05, Vol.306 (9), p.R647-R662

2014

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Synergistic Stimulation of Aldosterone Production in Human Adrenocortical Carcinoma NCI-H295R Cells by Endothelin-1 and Angiotensin II

Journal of cardiovascular pharmacology, 2004-11, Vol.44 Suppl 1 (Supplement 1), p.S289-S292

2004

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Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy

Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

Direct Renin Inhibitors as a New Therapy for Hypertension

The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey

Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage

Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats

Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker

A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3 –P1 Pharmacophore

Beneficial Effects of Combined Benazepril-Amlodipine on Cardiac Nitric Oxide, cGMP, and TNF-α Production After Cardiac Ischemia

Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors

Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP

Efficacy and safety of sacubitril/valsartan compared with olmesartan in Asian patients with essential hypertension: A randomized, double‐blind, 8‐week study

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

Renin inhibition with aliskiren : where are we now, and where are we going?

Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats

P-664: Combined benazepril-amlodipine treatment improves cardiac nitric oxide and cGMP production post cardiac ischemia

P-651: Combined benazepril-amlodipine treatment reduces cardiac TNFa production post cardiac ischemia

Effects of Valsartan and Valeryl 4-Hydroxy Valsartan on Human Platelets: A Possible Additional Mechanism for Clinical Benefits

Differences in AT2-receptor stimulation between AT1-receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP

A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model

Synergistic Stimulation of Aldosterone Production in Human Adrenocortical Carcinoma NCI-H295R Cells by Endothelin-1 and Angiotensin II

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