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Engineering Anti-Tumor Monoclonal Antibodies and Fc Receptors to Enhance ADCC by Human NK Cells

Cancers, 2021-01, Vol.13 (2), p.312

2021

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NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

Blood, 2013-05, Vol.121 (18), p.3599-3608

2013

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A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

Molecular therapy, 2020-01, Vol.28 (1), p.52-63

2020

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Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Nature communications, 2022-11, Vol.13 (1), p.7341-7341, Article 7341

2022

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Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells

PloS one, 2015-03, Vol.10 (3), p.e0121788

2015

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Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17

The Journal of biological chemistry, 2017-04, Vol.292 (15), p.6339-6351

2017

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Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis

Frontiers in cellular and infection microbiology, 2017-04, Vol.7, p.138-138

2017

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Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation

Frontiers in immunology, 2021-07, Vol.12, p.711621-711621

2021

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Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis

International journal of molecular sciences, 2020-09, Vol.21 (18), p.6688

2020

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Expression of a Recombinant High Affinity IgG Fc Receptor by Engineered NK Cells as a Docking Platform for Therapeutic mAbs to Target Cancer Cells

Frontiers in immunology, 2018-12, Vol.9, p.2873-2873

2018

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Role of ADAM17 in the ectodomain shedding of TNF-α and its receptors by neutrophils and macrophages

Journal of leukocyte biology, 2007-07, Vol.82 (1), p.173-176

2007

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An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model

Frontiers in immunology, 2022-06, Vol.13, p.918881-918881

2022

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Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

The Journal of immunology (1950), 2009-02, Vol.182 (4), p.2449-2457

2009

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iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma

Frontiers in immunology, 2024-07, Vol.15, p.1407567

2024

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Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study

PloS one, 2019-06, Vol.14 (6), p.e0217868-e0217868

2019

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Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells

Frontiers in immunology, 2022-02, Vol.13, p.841859-841859

2022

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Different Signaling Pathways Stimulate a Disintegrin and Metalloprotease-17 (ADAM17) in Neutrophils during Apoptosis and Activation

The Journal of biological chemistry, 2011-11, Vol.286 (45), p.38980-38988

2011

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508 IL-15-stimulated NK cell proliferation is greatly augmented by the anti-ADAM17 mAb Medi-1 and requires CD137

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A571-A572

2023

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In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli-mediated peritonitis

Journal of leukocyte biology, 2010-06, Vol.87 (6), p.1097-1101

2010

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Functional Interactions between Tumor and Peripheral Nerve: Morphology, Algogen Identification, and Behavioral Characterization of a New Murine Model of Cancer Pain

The Journal of neuroscience, 2001-12, Vol.21 (23), p.9355-9366

2001

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ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment

Journal of leukocyte biology, 2012-09, Vol.92 (3), p.667-672

2012

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Detection of Antibody-Dependent Cell-Mediated Cytotoxicity-Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization

Antibodies (Basel), 2023-06, Vol.12 (3), p.44

2023

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iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting

Journal for immunotherapy of cancer, 2023-12, Vol.11 (12), p.e007280

2023

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Enhancement of NK Cell Antitumor Effector Functions Using a Bispecific Single Domain Antibody Targeting CD16 and the Epidermal Growth Factor Receptor

Cancers, 2021-10, Vol.13 (21), p.5446

2021

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Engineering Anti-Tumor Monoclonal Antibodies and Fc Receptors to Enhance ADCC by Human NK Cells

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells

Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17

Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis

Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation

Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis

Expression of a Recombinant High Affinity IgG Fc Receptor by Engineered NK Cells as a Docking Platform for Therapeutic mAbs to Target Cancer Cells

Role of ADAM17 in the ectodomain shedding of TNF-α and its receptors by neutrophils and macrophages

An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study

Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells

Different Signaling Pathways Stimulate a Disintegrin and Metalloprotease-17 (ADAM17) in Neutrophils during Apoptosis and Activation

508 IL-15-stimulated NK cell proliferation is greatly augmented by the anti-ADAM17 mAb Medi-1 and requires CD137

In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli-mediated peritonitis

Functional Interactions between Tumor and Peripheral Nerve: Morphology, Algogen Identification, and Behavioral Characterization of a New Murine Model of Cancer Pain

ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment

Detection of Antibody-Dependent Cell-Mediated Cytotoxicity-Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization

iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting

Enhancement of NK Cell Antitumor Effector Functions Using a Bispecific Single Domain Antibody Targeting CD16 and the Epidermal Growth Factor Receptor

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