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Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

The Journal of cell biology, 2016-04, Vol.213 (2), p.173-184

2016

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Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis

Cancer research (Chicago, Ill.), 2010-05, Vol.70 (10), p.4151-4162

2010

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Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.24995-25009

2014

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Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation

PloS one, 2017-01, Vol.12 (1), p.e0169026-e0169026

2017

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Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation

PloS one, 2013-04, Vol.8 (4), p.e60549-e60549

2013

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Chemical genetic approach identifies microtubule affinity‐regulating kinase 1 as a leucine‐rich repeat kinase 2 substrate

The FASEB journal, 2015-07, Vol.29 (7), p.2980-2992

2015

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Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging

Journal of extracellular vesicles, 2019-12, Vol.8 (1), p.1663043-n/a

2019

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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region

MedChemComm, 2017-08, Vol.8 (8), p.1604-1613

2017

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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge regionThe authors declare no competing interests.Electronic supplementary information (ESI) available. CCDC 1546562. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7md00213k

2017-08

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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. CCDC 1546562. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7md00213k

MedChemComm, 2017-06, Vol.8 (8), p.1604-1613

2017

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Targeting Fibroblast Growth Factor Receptors Blocks P13K/AKT Signaling, Induces Apoptosis, and Impairs Mammary Tumor Outgrowth and Metastasis

Cancer research (Chicago, Ill.), 2010, Vol.70 (10), p.4151-4162

2010

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Abstract 4466: Characterization of the pan class I PI3K inhibitor NVP-BKM120 mechanism of action across a broad range of concentrations

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4466-4466

2011

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Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5

Journal of neuroscience research, 1997-03, Vol.47 (6), p.655-665

1997

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Antibody-based arrays in disease proteomics

Antibody Technology Journal, 2015-01, p.15

2015

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Characterization of kinase inhibitors using reverse phase protein arrays

Methods in molecular biology (Clifton, N.J.), 2011, Vol.785, p.79

2011

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Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles

The Journal of biological chemistry, 2002-09, Vol.277 (37), p.34182-34190

2002

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Thyroid Hormone Effects on Whole-Body Energy Homeostasis and Tissue-Specific Fatty Acid Uptake in Vivo

Endocrinology (Philadelphia), 2009-12, Vol.150 (12), p.5639-5648

2009

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Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: Studies using genetically engineered mouse models

Biochimica et biophysica acta, 2009-06, Vol.1791 (6), p.479-485

2009

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Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications

The Journal of clinical investigation, 2002-11, Vol.110 (9), p.1243-1250

2002

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Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice

Food and chemical toxicology, 2011-06, Vol.49 (6), p.1426-1430

2011

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Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin

PloS one, 2015-03, Vol.10 (3), p.e0121055-e0121055

2015

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Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis

PAX8 and MECOM are interaction partners driving ovarian cancer

Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation

Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation

Chemical genetic approach identifies microtubule affinity‐regulating kinase 1 as a leucine‐rich repeat kinase 2 substrate

Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging

Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4

Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic properties in preclinical models

Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region

Targeting Fibroblast Growth Factor Receptors Blocks P13K/AKT Signaling, Induces Apoptosis, and Impairs Mammary Tumor Outgrowth and Metastasis

Abstract 4466: Characterization of the pan class I PI3K inhibitor NVP-BKM120 mechanism of action across a broad range of concentrations

Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5

Antibody-based arrays in disease proteomics

Characterization of kinase inhibitors using reverse phase protein arrays

Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles

Thyroid Hormone Effects on Whole-Body Energy Homeostasis and Tissue-Specific Fatty Acid Uptake in Vivo

Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance

Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: Studies using genetically engineered mouse models

Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications

Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin

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