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Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

Clinical pharmacology and therapeutics, 2015-09, Vol.98 (3), p.298-308

2015

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing

Clinical pharmacology and therapeutics, 2015-07, Vol.98 (1), p.19-24

2015

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Precision Medicine—Nobody Is Average

Clinical pharmacology and therapeutics, 2017-03, Vol.101 (3), p.304-307

Vinks, AA

2017

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Development of a Physiologically‐Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content

CPT: pharmacometrics and systems pharmacology, 2013-07, Vol.2 (7), p.1-9

2013

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Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study

Clinical pharmacology and therapeutics, 2019-03, Vol.105 (3), p.761-768

2019

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Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants

CPT: pharmacometrics and systems pharmacology, 2016-08, Vol.5 (8), p.411-417

2016

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Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2: Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients

European journal of pharmaceutics and biopharmaceutics, 2002-07, Vol.54 (1), p.25-32

2002

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The Future of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure in Pregnant Women

CPT: pharmacometrics and systems pharmacology, 2013-03, Vol.2 (3), p.1-3

Vinks, AA

2013

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Inosine Monophosphate Dehydrogenase (IMPDH) Activity as a Pharmacodynamic Biomarker of Mycophenolic Acid Effects in Pediatric Kidney Transplant Recipients

Journal of clinical pharmacology, 2011-03, Vol.51 (3), p.309-320

2011

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Learning Health Systems as Facilitators of Precision Medicine

Clinical pharmacology and therapeutics, 2017-03, Vol.101 (3), p.359-367

2017

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Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter

CPT: pharmacometrics and systems pharmacology, 2017-02, Vol.6 (2), p.110-119

2017

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Pharmacogenetics in perioperative medicine

Current opinion in anaesthesiology, 2012-08, Vol.25 (4), p.419-427

2012

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An Integrated Population Pharmacokinetic Meta‐Analysis of Propofol in Morbidly Obese and Nonobese Adults, Adolescents, and Children

CPT: pharmacometrics and systems pharmacology, 2013-09, Vol.2 (9), p.1-8

2013

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Pharmacokinetics and Safety of Single‐Dose Inhaled Loxapine in Children and Adolescents

Journal of clinical pharmacology, 2017-10, Vol.57 (10), p.1244-1257

2017

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UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients

Therapeutic drug monitoring, 2012-12, Vol.34 (6), p.671-679

2012

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Cost-effectiveness of therapeutic drug monitoring: a systematic review

Therapeutic drug monitoring, 2005-02, Vol.27 (1), p.10-17

2005

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Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: The minimum inhibitory concentration versus stationary concentration

Clinical pharmacokinetics, 2005-01, Vol.44 (2), p.201-210

2005

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Developmental Changes in Morphine Clearance Across the Entire Paediatric Age Range are Best Described by a Bodyweight-Dependent Exponent Model

Clinical drug investigation, 2013-07, Vol.33 (7), p.523-534

2013

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Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants

CPT: pharmacometrics and systems pharmacology, 2015-02, Vol.4 (2), p.127-134

2015

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Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients

Critical care medicine, 2003-07, Vol.31 (7), p.1952-1958

2003

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UGT Genotype May Contribute to Adverse Events Following Medication With Mycophenolate Mofetil in Pediatric Kidney Transplant Recipients

Clinical pharmacology and therapeutics, 2009-05, Vol.85 (5), p.495-500

2009

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Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype

Pharmacogenetics and genomics, 2006-05, Vol.16 (5), p.359-367

2006

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A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit

Clinical therapeutics, 2005-06, Vol.27 (6), p.762-772

2005

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Relationship Between Minimum Inhibitory Concentration and Stationary Concentration Revisited

Clinical pharmacokinetics, 2005, Vol.44 (7), p.767-768

2005

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The application of population pharmacokinetic modeling to individualized antibiotic therapy

International journal of antimicrobial agents, 2002-04, Vol.19 (4), p.313-322

Vinks, Alexander A.

2002

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Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing

Precision Medicine—Nobody Is Average

Development of a Physiologically‐Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content

Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study

Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants

Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2: Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients

The Future of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure in Pregnant Women

Inosine Monophosphate Dehydrogenase (IMPDH) Activity as a Pharmacodynamic Biomarker of Mycophenolic Acid Effects in Pediatric Kidney Transplant Recipients

Learning Health Systems as Facilitators of Precision Medicine

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter

Pharmacogenetics in perioperative medicine

An Integrated Population Pharmacokinetic Meta‐Analysis of Propofol in Morbidly Obese and Nonobese Adults, Adolescents, and Children

Pharmacokinetics and Safety of Single‐Dose Inhaled Loxapine in Children and Adolescents

UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients

Cost-effectiveness of therapeutic drug monitoring: a systematic review

Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: The minimum inhibitory concentration versus stationary concentration

Developmental Changes in Morphine Clearance Across the Entire Paediatric Age Range are Best Described by a Bodyweight-Dependent Exponent Model

Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants

Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients

UGT Genotype May Contribute to Adverse Events Following Medication With Mycophenolate Mofetil in Pediatric Kidney Transplant Recipients

Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype

A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit

Relationship Between Minimum Inhibitory Concentration and Stationary Concentration Revisited

The application of population pharmacokinetic modeling to individualized antibiotic therapy

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