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Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3‑Kinase (PI3K) β Inhibitor

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6858-6868

2018

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Protein Footprinting and X‑ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide

Biochemistry (Easton), 2020-02, Vol.59 (4), p.541-551

2020

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Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2428-2436

2019

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Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ

The Journal of biological chemistry, 2015-03, Vol.290 (13), p.8439-8446

2015

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Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis

Journal of chemical information and modeling, 2020-07, Vol.60 (7), p.3489-3498

2020

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Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9

The Journal of biological chemistry, 2017-04, Vol.292 (16), p.6810-6820

2017

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Discovery of Orally Efficacious Phosphoinositide 3‑Kinase δ Inhibitors with Improved Metabolic Stability

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9228-9242

2016

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2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3532-3548

2016

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Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10414-10423

2012

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Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 2013-02, Vol.56 (4), p.1677-1692

2013

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Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Protein science, 2011-02, Vol.20 (2), p.428-436

2011

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Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations

Journal of Immunology, 2007-03, Vol.178 (5), p.2641-2645

2007

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Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias

Acta crystallographica. Section D, Biological crystallography., 2010-05, Vol.66 (5), p.568-576

2010

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Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.541-546

2018

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Structural Insights for Design of Potent Spleen Tyrosine Kinase Inhibitors from Crystallographic Analysis of Three Inhibitor Complexes

Chemical biology & drug design, 2009-04, Vol.73 (4), p.466-470

2009

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The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity

Journal of molecular biology, 2008-11, Vol.383 (4), p.885-893

2008

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Crystal Structures of IL-2-inducible T cell Kinase Complexed with Inhibitors: Insights into Rational Drug Design and Activity Regulation

Chemical biology & drug design, 2010-08, Vol.76 (2), p.154-163

2010

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X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5217-5220

2010

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Design of Annulated Pyrazoles as Inhibitors of HIV-1 Reverse Transcriptase

Journal of medicinal chemistry, 2008-12, Vol.51 (23), p.7449-7458

2008

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Nanolitre-scale crystallization using acoustic liquid-transfer technology

Acta crystallographica. Section D, Biological crystallography., 2012-08, Vol.68 (8), p.893-900

2012

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Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Benzyl derivatives with broad potency against resistant mutant viruses

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4215-4218

2010

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Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

MedChemComm, 2010-07, Vol.1 (1), p.79-83

2010

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Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (20), p.6020-6023

2010

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Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3‑Kinase (PI3K) β Inhibitor

Protein Footprinting and X‑ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi

Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ

Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9

Discovery of Orally Efficacious Phosphoinositide 3‑Kinase δ Inhibitors with Improved Metabolic Stability

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors

Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations

Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Structural Insights for Design of Potent Spleen Tyrosine Kinase Inhibitors from Crystallographic Analysis of Three Inhibitor Complexes

The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity

Crystal Structures of IL-2-inducible T cell Kinase Complexed with Inhibitors: Insights into Rational Drug Design and Activity Regulation

X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Design of Annulated Pyrazoles as Inhibitors of HIV-1 Reverse Transcriptase

Nanolitre-scale crystallization using acoustic liquid-transfer technology

Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Benzyl derivatives with broad potency against resistant mutant viruses

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

Discovery of N‑[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo‑1H‑pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses

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