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Therapeutic implications of tumor interstitial acidification

Seminars in cancer biology, 2017-04, Vol.43, p.119-133

2017

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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Cancer letters, 2018-10, Vol.435, p.32-43

2018

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Pathobiology and Therapeutic Implications of Tumor Acidosis

Current medicinal chemistry, 2017-01, Vol.24 (26), p.2827

2017

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Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy

Molecular oncology, 2024-08, Vol.18 (8), p.1904-1922

2024

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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2533-2551

2018

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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target

ACS chemical biology, 2017-08, Vol.12 (8), p.1986-1992

2017

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Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

Nature communications, 2024-06, Vol.15 (1), p.5109-13

2024

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Studies on the active site of deacetoxycephalosporin C synthase

Journal of molecular biology, 1999-04, Vol.287 (5), p.943-960

1999

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Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy

Science advances, 2020-05, Vol.6 (18), p.eaax7881-eaax7881

2020

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Ligand-based design of 18FOXD-2314 for PET imaging in non-Alzheimer's disease tauopathies

Nature communications, 2024-06, Vol.15 (1), p.5109

2024

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Potency Prediction of β‑Secretase (BACE-1) Inhibitors Using Density Functional Methods

Journal of chemical information and modeling, 2014-03, Vol.54 (3), p.818-825

2014

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Potency Prediction of [Beta]-Secretase (BACE-1) Inhibitors Using Density Functional Methods

Journal of chemical information and modeling, 2014-03, Vol.54 (3), p.818

2014

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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9297-9311

2012

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Core Refinement toward Permeable β‑Secretase (BACE-1) Inhibitors with Low hERG Activity

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4181-4205

2013

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Abstract 5226: Novel class of potent and selective inhibitors efface MTH1 as broad-spectrum cancer target

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5226-5226

2017

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Abstract 2116: VPS34 inhibitor SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2116-2116

2022

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Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5919-5923

2012

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Creation of Novel Cores for β‑Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy

ACS medicinal chemistry letters, 2014-04, Vol.5 (4), p.440-445

2014

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Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1397-1401

2006

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Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.5095-5099

2005

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Correction to New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10316-10316

2012

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Liver X receptor agonists with selectivity for LXRp; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (7), p.2009-2012

2009

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Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.2009-2012

2009

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Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.2009-2012

2009

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Therapeutic implications of tumor interstitial acidification

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Pathobiology and Therapeutic Implications of Tumor Acidosis

Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target

Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

Studies on the active site of deacetoxycephalosporin C synthase

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy

Ligand-based design of 18FOXD-2314 for PET imaging in non-Alzheimer's disease tauopathies

Potency Prediction of β‑Secretase (BACE-1) Inhibitors Using Density Functional Methods

Potency Prediction of [Beta]-Secretase (BACE-1) Inhibitors Using Density Functional Methods

New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Development of Inhibitors of PIP4K2 As a Treatment for Patients with Hematologic Malignancies

Core Refinement toward Permeable β‑Secretase (BACE-1) Inhibitors with Low hERG Activity

Abstract 5226: Novel class of potent and selective inhibitors efface MTH1 as broad-spectrum cancer target

Abstract 2116: VPS34 inhibitor SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist

Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors

Creation of Novel Cores for β‑Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy

Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3

Correction to New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Liver X receptor agonists with selectivity for LXRp; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

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