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Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Drug design, development and therapy, 2020-08, Vol.14, p.3235-3249

2020

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Biological and Chemical Aspects of Natural Biflavonoids from Plants: A Brief Review

Mini reviews in medicinal chemistry, 2017-01, Vol.17 (10), p.834

2017

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The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones

Molecules (Basel, Switzerland), 2018-07, Vol.23 (7), p.1803

2018

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Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer’s Disease: An Update

Current medicinal chemistry, 2018-01, Vol.25 (29), p.3491-3525

2018

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Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer's Disease

Current neuropharmacology, 2014-05, Vol.12 (3), p.239-255

2014

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Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

Current neuropharmacology, 2020-01, Vol.18 (5), p.348-407

2020

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Piperine-Chlorogenic Acid Hybrid Inhibits the Proliferation of the SK-MEL-147 Melanoma Cells by Modulating Mitotic Kinases

Pharmaceuticals (Basel, Switzerland), 2023-01, Vol.16 (2), p.145

2023

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Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

Current drug targets, 2021-01, Vol.22 (5), p.505-538

2021

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Mass spectrometry for characterization of homologous piperidine alkaloids and their activity as acetylcholinesterase inhibitors

Rapid communications in mass spectrometry, 2018-08, Vol.32 (15), p.1303-1310

2018

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An international film dosimetry intercomparison to establish a multi-center audit framework

Medical physics (Lancaster), 2024-09

2024

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A synthetic resveratrol-curcumin hybrid derivative exhibits chemopreventive effects on colon pre-neoplastic lesions by targeting Wnt/β-catenin signaling, anti-inflammatory and antioxidant pathways

Journal of pharmacy and pharmacology, 2024-05, Vol.76 (5), p.479-488

2024

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Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp

Food chemistry, 2012-06, Vol.132 (3), p.1230-1235

2012

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Antinociceptive Effect of Dillenia indica (Linn.) Mediated by Opioid and Cannabinoid Systems: Pharmacological and Chemical Studies

Chemistry & biodiversity, 2024-03, Vol.21 (3), p.e202301508-n/a

2024

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Donepezil: an important prototype to the design of new drug candidates for Alzheimer's disease

Mini reviews in medicinal chemistry, 2014-01, Vol.14 (1), p.2-19

2014

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The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease

CNS & neurological disorders drug targets, 2011-03, Vol.10 (2), p.251-270

2011

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Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents

Current neuropharmacology, 2022-01, Vol.20 (7), p.1297-1328

2022

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The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy

Marine drugs, 2024-05, Vol.22 (6), p.244

2024

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Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease

Bioorganic chemistry, 2024-09, Vol.150, p.107587, Article 107587

2024

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Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?

Frontiers in pharmacology, 2020-12, Vol.11, p.609274-609274

2020

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Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry

Pure and applied chemistry, 2012-07, Vol.84 (9), p.1837-1846

2012

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The genus Caesalpinia L. (Caesalpiniaceae): phytochemical and pharmacological characteristics

Molecules, 2012-06, Vol.17 (7), p.7887-7902

2012

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New multifunctional AChE inhibitor drug prototypes protect against Aβ-induced memory deficit

Neurological sciences, 2020-02, Vol.41 (2), p.451-455

2020

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Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases

Neurochemical research, 2020-12, Vol.45 (12), p.3003-3020

2020

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Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells

Toxicology in vitro, 2018-08, Vol.50, p.75-85

2018

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Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis

Phytomedicine (Stuttgart), 2014-02, Vol.21 (3), p.277-281

2014

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Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Biological and Chemical Aspects of Natural Biflavonoids from Plants: A Brief Review

The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones

Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer’s Disease: An Update

Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer's Disease

Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

Piperine-Chlorogenic Acid Hybrid Inhibits the Proliferation of the SK-MEL-147 Melanoma Cells by Modulating Mitotic Kinases

Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

Mass spectrometry for characterization of homologous piperidine alkaloids and their activity as acetylcholinesterase inhibitors

An international film dosimetry intercomparison to establish a multi-center audit framework

A synthetic resveratrol-curcumin hybrid derivative exhibits chemopreventive effects on colon pre-neoplastic lesions by targeting Wnt/β-catenin signaling, anti-inflammatory and antioxidant pathways

Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp

Antinociceptive Effect of Dillenia indica (Linn.) Mediated by Opioid and Cannabinoid Systems: Pharmacological and Chemical Studies

Donepezil: an important prototype to the design of new drug candidates for Alzheimer's disease

The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease

Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents

The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy

Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease

Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?

Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry

The genus Caesalpinia L. (Caesalpiniaceae): phytochemical and pharmacological characteristics

New multifunctional AChE inhibitor drug prototypes protect against Aβ-induced memory deficit

Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases

Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells

Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis

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