UB Paderborn / Katalog / Suche / in CDI

Fish bioaccumulation and biomarkers in environmental risk assessment: a review

Environmental Toxicology and Pharmacology, 2003-02, Vol.13 (2), p.57-149

2003

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Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

Archives of toxicology, 2016-12, Vol.90 (12), p.2979-3003

2016

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Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines

Toxicology letters, 2016-06, Vol.253, p.46-54

2016

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Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis

Hepatology (Baltimore, Md.), 2011-06, Vol.53 (6), p.2027-2041

2011

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Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

Toxicology in vitro, 2016-06, Vol.33, p.71-79

2016

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Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

Proteins, structure, function, and bioinformatics, 2016-03, Vol.84 (3), p.383-396

2016

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Cytochrome P450-Mediated Bioactivation of Mefenamic Acid to Quinoneimine Intermediates and Inactivation by Human Glutathione S‑Transferases

Chemical research in toxicology, 2014-12, Vol.27 (12), p.2071-2081

2014

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Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol

Toxicology letters, 2016-07, Vol.255, p.52-62

2016

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The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae

PloS one, 2017-03, Vol.12 (3), p.e0173573-e0173573

2017

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Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

Bioorganic & medicinal chemistry, 2014-10, Vol.22 (20), p.5613-5620

2014

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Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

Analytical and bioanalytical chemistry, 2016-02, Vol.408 (5), p.1425-1443

2016

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Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid

Chemical research in toxicology, 2014-04, Vol.27 (4), p.576-586

2014

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Effect of Human Glutathione S‑Transferases on Glutathione-Dependent Inactivation of Cytochrome P450-Dependent Reactive Intermediates of Diclofenac

Chemical research in toxicology, 2013-11, Vol.26 (11), p.1632-1641

2013

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Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione‑S‑transferase P1‑1

Chemical research in toxicology, 2012-11, Vol.25 (11), p.2532-2541

2012

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Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine

Toxicology in vitro, 2018-03, Vol.47, p.259-268

2018

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Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450

Expert opinion on drug metabolism & toxicology, 2008-05, Vol.4 (5), p.513-527

2008

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Characterization of Human Cytochrome P450s Involved in the Bioactivation of Tri-ortho-cresyl Phosphate (ToCP)

Chemical research in toxicology, 2015-04, Vol.28 (4), p.711-721

2015

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Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

Toxicology letters, 2015-01, Vol.232 (1), p.182-192

2015

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Metabolism related toxicity of diclofenac in yeast as model system

Toxicology letters, 2011-02, Vol.200 (3), p.162-168

2011

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Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-03, Vol.878 (7), p.667-674

2010

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Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico—Implications for differences in activity, subunit dimerization and substrate inhibition

Molecular and cellular endocrinology, 2010-04, Vol.317 (1), p.127-140

2010

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Application of a fluorescence-based continuous-flow bioassay to screen for diversity of cytochrome P450 BM3 mutant libraries

Journal of biomolecular screening, 2011-02, Vol.16 (2), p.239-250

2011

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Regio- and Stereoselective Hydroxylation of Optically Active [alpha]-Ionone Enantiomers by Engineered Cytochrome P450 BM3 Mutants

Advanced synthesis & catalysis, 2012-08, Vol.354 (11-12), p.2172-2184

2012

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Endocrine disrupting chemicals—Linking internal exposure to vitellogenin levels and ovotestis in Abramis brama from Dutch surface waters

Environmental toxicology and pharmacology, 2010-11, Vol.30 (3), p.209-223

2010

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Diclofenac inhibits tumor necrosis factor-[alpha]-induced nuclear factor-[kappa]B activation causing synergistic hepatocyte apoptosis

Hepatology (Baltimore, Md.), 2011-06, Vol.53 (6), p.2027

2011

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Fish bioaccumulation and biomarkers in environmental risk assessment: a review

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines

Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

Cytochrome P450-Mediated Bioactivation of Mefenamic Acid to Quinoneimine Intermediates and Inactivation by Human Glutathione S‑Transferases

Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol

The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae

Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid

Effect of Human Glutathione S‑Transferases on Glutathione-Dependent Inactivation of Cytochrome P450-Dependent Reactive Intermediates of Diclofenac

Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione‑S‑transferase P1‑1

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine

Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450

Characterization of Human Cytochrome P450s Involved in the Bioactivation of Tri-ortho-cresyl Phosphate (ToCP)

Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

Metabolism related toxicity of diclofenac in yeast as model system

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico—Implications for differences in activity, subunit dimerization and substrate inhibition

Application of a fluorescence-based continuous-flow bioassay to screen for diversity of cytochrome P450 BM3 mutant libraries

Regio- and Stereoselective Hydroxylation of Optically Active [alpha]-Ionone Enantiomers by Engineered Cytochrome P450 BM3 Mutants

Endocrine disrupting chemicals—Linking internal exposure to vitellogenin levels and ovotestis in Abramis brama from Dutch surface waters

Diclofenac inhibits tumor necrosis factor-[alpha]-induced nuclear factor-[kappa]B activation causing synergistic hepatocyte apoptosis

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