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Function-Oriented Synthesis, Step Economy, and Drug Design

Accounts of chemical research, 2008-01, Vol.41 (1), p.40-49

2008

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Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.6721-6726

2011

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Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14357-14381

2020

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The Design, Synthesis, and Evaluation of C7 Diversified Bryostatin Analogs Reveals a Hot Spot for PKC Affinity

Organic letters, 2008-08, Vol.10 (15), p.3331-3334

2008

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A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts

Neurobiology of disease, 2009-05, Vol.34 (2), p.332-339

2009

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Total Synthesis and Initial Biological Evaluation of New B-Ring-Modified Bryostatin Analogs

Organic letters, 2006-11, Vol.8 (23), p.5299-5302

2006

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Actin is the primary cellular receptor of bistramide A

Nature chemical biology, 2005-12, Vol.1 (7), p.383-388

2005

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Design, Synthesis, and Biological Evaluation of a Potent, PKC Selective, B-Ring Analog of Bryostatin

Organic letters, 2006-04, Vol.8 (9), p.1893-1896

2006

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A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

The Journal of experimental medicine, 2021-04, Vol.218 (4)

2021

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Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4085-4120

2022

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The cryptophycins as potent payloads for antibody drug conjugates

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.864-868

2015

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Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

Journal of natural products (Washington, D.C.), 2016-04, Vol.79 (4), p.675-679

2016

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α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.495-498

2016

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Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation

Molecular carcinogenesis, 2004-11, Vol.41 (3), p.164-178

2004

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Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (22), p.6967-6973

2012

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Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5652-5657

2012

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Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells

Oncogene, 2004-06, Vol.23 (28), p.4945-4958

2004

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The double addition reaction of alkoxymethyl nucleophiles to esters to generate novel polyoxygenated species

Tetrahedron letters, 2010-08, Vol.51 (32), p.4284-4286

2010

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A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts

Neurobiology of disease, 2009-05, Vol.34 (2), p.332

2009

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Beyond Natural Products: Synthetic Analogues of Bryostatin 1

Drug Discovery Research, 2007, p.125-162

2007

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ChemInform Abstract: The Double Addition Reaction of Alkoxymethyl Nucleophiles to Esters to Generate Novel Polyoxygenated Species

ChemInform, 2010-11, Vol.41 (48), p.no-no

2010

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ChemInform Abstract: Function-Oriented Synthesis, Step Economy, and Drug Design

ChemInform, 2008-04, Vol.39 (17), p.no-no

2008

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Function-Oriented Synthesis, Step Economy, and Drug Design

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients

The Design, Synthesis, and Evaluation of C7 Diversified Bryostatin Analogs Reveals a Hot Spot for PKC Affinity

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts

Total Synthesis and Initial Biological Evaluation of New B-Ring-Modified Bryostatin Analogs

Actin is the primary cellular receptor of bistramide A

Design, Synthesis, and Biological Evaluation of a Potent, PKC Selective, B-Ring Analog of Bryostatin

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity

The cryptophycins as potent payloads for antibody drug conjugates

Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody–Drug Conjugates

α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists

Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation

5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors

Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors

Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors

Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells

The double addition reaction of alkoxymethyl nucleophiles to esters to generate novel polyoxygenated species

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts

Beyond Natural Products: Synthetic Analogues of Bryostatin 1

ChemInform Abstract: The Double Addition Reaction of Alkoxymethyl Nucleophiles to Esters to Generate Novel Polyoxygenated Species

ChemInform Abstract: Function-Oriented Synthesis, Step Economy, and Drug Design

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