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Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy

Frontiers in oncology, 2016-11, Vol.6, p.233-233

2016

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Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

Cancer research (Chicago, Ill.), 2012-07, Vol.72 (13), p.3163-3174

2012

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The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

Cancer research (Chicago, Ill.), 2016-03, Vol.76 (5), p.1158-1169

2016

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Pharmacodynamic, prognostic, and predictive biomarkers in severe and critical COVID-19 patients treated with sirukumab

Scientific reports, 2024-10, Vol.14 (1), p.22981-11, Article 22981

2024

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Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

Cell reports (Cambridge), 2021-11, Vol.37 (7), p.110013-110013, Article 110013

2021

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Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Receptor 1[S]

The Journal of biological chemistry, 2013-03, Vol.288 (9), p.6617-6628

2013

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Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma

Cancer Immunology, Immunotherapy, 2016-06, Vol.65 (6), p.753-763

2016

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The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling

Radiation research, 2014-08, Vol.182 (2), p.219

2014

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Enhancing radiation response by a second-generation TRAIL receptor agonist using a new in vitro organoid model system

Clinical and translational radiation oncology, 2020-09, Vol.24, p.1-9

2020

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Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in PtenLoxP/LoxP;BrafCA/+ Mice

International journal of molecular sciences, 2016-12, Vol.17 (12), p.2149

2016

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Combining Radiotherapy with APO010 in Cancer Treatment

Clinical cancer research, 2009-03, Vol.15 (6), p.2031-2038

2009

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Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

Oncoimmunology, 2012-12, Vol.1 (9), p.1629-1631

2012

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PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice

The Journal of clinical investigation, 2024-03, Vol.134 (6), p.1-15

2024

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PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice

The Journal of clinical investigation, 2024-03, Vol.134 (6)

2024

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SnapShot: Extrinsic Apoptosis Pathways

Cell, 2010-12, Vol.143 (7), p.1192-1192.e2

2010

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Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

Blood, 2014-02, Vol.123 (9), p.1341-1352

2014

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Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma

Oncoimmunology, 2016-12, Vol.5 (12), p.e1238557-e1238557

2016

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The IL-6 hypothesis in COVID-19: A phase 2, randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of free IL-6 sequestration by the monoclonal antibody sirukumab in severe and critical COVID-19

The Journal of infection, 2024-10, Vol.89 (4), p.106241, Article 106241

2024

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A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults

Antiviral therapy, 2023-06, Vol.28 (3), p.13596535231172878-13596535231172878

2023

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PD-1 and CTLA-4 blockade promote CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice

The Journal of clinical investigation, 2024-02

2024

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Radiotherapy and Cisplatin Increase Immunotherapy Efficacy by Enabling Local and Systemic Intratumoral T-cell Activity

Cancer immunology research, 2019-04, Vol.7 (4), p.670-682

2019

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Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants

Antiviral therapy, 2023-02, Vol.28 (1), p.13596535231151626

2023

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Cyclin-dependent kinase inhibitor, dinaciclib induces anti-tumour activity of MLL-AF9 in vivo mouse models

Experimental hematology, 2013-08, Vol.41 (8), p.S53-S53

2013

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Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten super(LoxP/LoxP); B raf super(CA/+) Mice

International journal of molecular sciences, 2016-12, Vol.17 (12), p.2149-2149

2016

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Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

Pharmacodynamic, prognostic, and predictive biomarkers in severe and critical COVID-19 patients treated with sirukumab

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Receptor 1[S]

Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma

The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling

Enhancing radiation response by a second-generation TRAIL receptor agonist using a new in vitro organoid model system

Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in PtenLoxP/LoxP;BrafCA/+ Mice

Combining Radiotherapy with APO010 in Cancer Treatment

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice

PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice

SnapShot: Extrinsic Apoptosis Pathways

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma

The IL-6 hypothesis in COVID-19: A phase 2, randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of free IL-6 sequestration by the monoclonal antibody sirukumab in severe and critical COVID-19

A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults

PD-1 and CTLA-4 blockade promote CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice

Radiotherapy and Cisplatin Increase Immunotherapy Efficacy by Enabling Local and Systemic Intratumoral T-cell Activity

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants

Cyclin-dependent kinase inhibitor, dinaciclib induces anti-tumour activity of MLL-AF9 in vivo mouse models

Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten super(LoxP/LoxP); B raf super(CA/+) Mice

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