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A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

CPT: pharmacometrics and systems pharmacology, 2015-06, Vol.4 (6), p.324-337

2015

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A Six‐Stage Workflow for Robust Application of Systems Pharmacology

CPT: pharmacometrics and systems pharmacology, 2016-05, Vol.5 (5), p.235-249

2016

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Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014)

CPT: pharmacometrics and systems pharmacology, 2017-07, Vol.6 (7), p.418-429

2017

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Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

CPT: pharmacometrics and systems pharmacology, 2017-08, Vol.6 (8), p.496-498

2017

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Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis With Nonlinear Mixed Effects Models

CPT: Pharmacometrics & Systems Pharmacology, 2014-12, Vol.3 (12), p.1-2

Graaf, PH

2014

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Integrated Pharmacometrics and Systems Pharmacology Model‐Based Analyses to Guide GnRH Receptor Modulator Development for Management of Endometriosis

CPT: pharmacometrics and systems pharmacology, 2012-10, Vol.1 (10), p.1-9

2012

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Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study

CPT: pharmacometrics and systems pharmacology, 2016-07, Vol.5 (7), p.339-351

2016

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Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic‐Pharmacodynamic Behavior: An Example Using 5‐Lipoxygenase Inhibitors

CPT: pharmacometrics and systems pharmacology, 2013-09, Vol.2 (9), p.1-9

2013

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A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain

CPT: pharmacometrics and systems pharmacology, 2014-01, Vol.3 (1), p.1-7

2014

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Database: A New Article Type in CPT: Pharmacometrics & Systems Pharmacology

CPT: pharmacometrics and systems pharmacology, 2015-08, Vol.4 (8), p.443-444

2015

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Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point

Journal of allergy and clinical immunology, 2013-10, Vol.132 (4), p.847-855.e5

2013

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Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae

Scientific reports, 2019-02, Vol.9 (1), p.2149, Article 2149

2019

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Systems Approaches Evolve Clinical Pharmacology

CPT: pharmacometrics and systems pharmacology, 2013-08, Vol.2 (8), p.1-2

2013

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CPT: Pharmacometrics & Systems Pharmacology Publishes Its 100th Article

CPT: pharmacometrics and systems pharmacology, 2014-03, Vol.3 (3), p.1-2

2014

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What Pharmacometricians (Should) Do

CPT: pharmacometrics and systems pharmacology, 2013-05, Vol.2 (5), p.1-1

Graaf, PH

2013

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Regulatory Modeling and Simulation Moves Into the Next Gear in Europe

CPT: pharmacometrics and systems pharmacology, 2013-02, Vol.2 (2), p.1-1

Graaf, PH

2013

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Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions

CPT: pharmacometrics and systems pharmacology, 2013-12, Vol.2 (12), p.1-3

2013

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Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor

The Journal of pharmacology and experimental therapeutics, 1998-03, Vol.284 (3), p.1095

1998

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Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

Journal of pharmacokinetics and pharmacodynamics, 2018-08, Vol.45 (4), p.621-635

2018

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The rise of systems pharmacology in drug discovery and development

Future medicinal chemistry, 2014-01, Vol.6 (16), p.1731-1734

2014

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Pharmacodynamic-pharmacokinetic integration as a guide to medicinal chemistry

Current topics in medicinal chemistry, 2011-02, Vol.11 (4), p.404-418

2011

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Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders

The European journal of neuroscience, 2005-08, Vol.22 (3), p.724-734

2005

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Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo

Pharmacology & therapeutics (Oxford), 2005-04, Vol.106 (1), p.1-18

2005

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Automated zebrafish toxicology screening: Effect assessment and uptake studies

Toxicology letters, 2015-10, Vol.238 (2), p.S54-S54

2015

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Estimation of binding rate constants using a simultaneous mixed‐effects method: application to monoamine transporter reuptake inhibitor reboxetine

British journal of pharmacology, 2010-05, Vol.160 (2), p.389-398

2010

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A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

A Six‐Stage Workflow for Robust Application of Systems Pharmacology

Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014)

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis With Nonlinear Mixed Effects Models

Integrated Pharmacometrics and Systems Pharmacology Model‐Based Analyses to Guide GnRH Receptor Modulator Development for Management of Endometriosis

Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study

Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic‐Pharmacodynamic Behavior: An Example Using 5‐Lipoxygenase Inhibitors

A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain

Database: A New Article Type in CPT: Pharmacometrics & Systems Pharmacology

Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae

Systems Approaches Evolve Clinical Pharmacology

CPT: Pharmacometrics & Systems Pharmacology Publishes Its 100th Article

What Pharmacometricians (Should) Do

Regulatory Modeling and Simulation Moves Into the Next Gear in Europe

Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

The rise of systems pharmacology in drug discovery and development

Pharmacodynamic-pharmacokinetic integration as a guide to medicinal chemistry

Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders

Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo

Automated zebrafish toxicology screening: Effect assessment and uptake studies

Estimation of binding rate constants using a simultaneous mixed‐effects method: application to monoamine transporter reuptake inhibitor reboxetine

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