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Towards a new combination therapy for tuberculosis with next generation benzothiazinones

EMBO molecular medicine, 2014-03, Vol.6 (3), p.372-383

2014

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New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

PLoS pathogens, 2020-01, Vol.16 (1), p.e1008270

2020

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Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

mBio, 2018-10, Vol.9 (5)

2018

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Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform

Nature communications, 2024-03, Vol.15 (1), p.2037-2037, Article 2037

2024

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Development and validation of a multiplex UHPLC-MS/MS method for the determination of the investigational antibiotic against multi-resistant tuberculosis macozinone (PBTZ169) and five active metabolites in human plasma

PloS one, 2019-05, Vol.14 (5), p.e0217139-e0217139

2019

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Investigating nanomotion-based technology (Resistell AST) for rapid antibiotic susceptibility testing among adult patients admitted to a tertiary-care hospital with Gram-negative bacteraemia: protocol for a prospective, observational, cross-sectional, single-arm study

BMJ open, 2022-11, Vol.12 (11), p.e064016-e064016

2022

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New 1-hydroxy-2-thiopyridine derivatives active against both replicating and dormant Mycobacterium tuberculosis

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2017-11, Vol.23 (11), p.794-797

2017

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Synthesis of Adamantane Aminoethers with Antitubercular Potential

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2017-01, Vol.13 (7), p.670

2017

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Structure-Based Drug Design and Characterization of Sulfonyl-Piperazine Benzothiazinone Inhibitors of DprE1 from Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2018-10, Vol.62 (10)

2018

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Nanomotion technology in combination with machine learning: a new approach for a rapid antibiotic susceptibility test for Mycobacterium tuberculosis

Microbes and infection, 2023-09, Vol.25 (7), p.105151-105151, Article 105151

2023

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Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)

Antimicrobial agents and chemotherapy, 2018-11, Vol.62 (11)

2018

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Machine Learning Models for Mycobacterium tuberculosis In Vitro Activity: Prediction and Target Visualization

Molecular pharmaceutics, 2022-02, Vol.19 (2), p.674-689

2022

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Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis

Journal of the American Chemical Society, 2017-06, Vol.139 (23), p.7974-7981

2017

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Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2362-2380

2016

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Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023-01, Vol.1215, p.123555-123555, Article 123555

2023

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Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2015-07, Vol.59 (7), p.4012-4019

2015

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The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2015-08, Vol.59 (8), p.4446-4452

2015

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In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2014-06, Vol.58 (6), p.3217-3223

2014

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CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

The Journal of clinical investigation, 2023-05, Vol.133 (10), p.1-16

2023

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Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway

Journal of medicinal chemistry, 2024-01, Vol.67 (1), p.81-109

2024

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Synthesis and Structure–Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

Journal of medicinal chemistry, 2020-02, Vol.63 (3), p.1105-1131

2020

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Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Cell host & microbe, 2014-10, Vol.16 (4), p.538-548

2014

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Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (11), p.1278-1281

2019

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Towards a new combination therapy for tuberculosis with next generation benzothiazinones

Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform

Development and validation of a multiplex UHPLC-MS/MS method for the determination of the investigational antibiotic against multi-resistant tuberculosis macozinone (PBTZ169) and five active metabolites in human plasma

Investigating nanomotion-based technology (Resistell AST) for rapid antibiotic susceptibility testing among adult patients admitted to a tertiary-care hospital with Gram-negative bacteraemia: protocol for a prospective, observational, cross-sectional, single-arm study

New 1-hydroxy-2-thiopyridine derivatives active against both replicating and dormant Mycobacterium tuberculosis

Synthesis of Adamantane Aminoethers with Antitubercular Potential

Structure-Based Drug Design and Characterization of Sulfonyl-Piperazine Benzothiazinone Inhibitors of DprE1 from Mycobacterium tuberculosis

Nanomotion technology in combination with machine learning: a new approach for a rapid antibiotic susceptibility test for Mycobacterium tuberculosis

Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)

Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3

Machine Learning Models for Mycobacterium tuberculosis In Vitro Activity: Prediction and Target Visualization

Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis

Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine

Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway

Synthesis and Structure–Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

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