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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Nature communications, 2018-04, Vol.9 (1), p.1416-16, Article 1416

2018

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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

Circulation (New York, N.Y.), 2017-03, Vol.135 (12), p.1160-1173

2017

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Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

American journal of respiratory and critical care medicine, 2020-03, Vol.201 (5), p.575-585

2020

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Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2

Circulation (New York, N.Y.), 2017-12, Vol.136 (25), p.2451-2467

2017

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TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Nature communications, 2017-01, Vol.8 (1), p.14079-14079, Article 14079

2017

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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

Nature medicine, 2015-07, Vol.21 (7), p.777-785

2015

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BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia

American journal of human genetics, 2013-09, Vol.93 (3), p.530-537

2013

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Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

American journal of respiratory and critical care medicine, 2021-06, Vol.203 (11), p.1419-1430

2021

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Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension

American journal of respiratory and critical care medicine, 2019-04, Vol.199 (7), p.891-902

2019

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An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension

Developmental dynamics, 2023-03, Vol.252 (3), p.327-342

2023

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Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

The Journal of biological chemistry, 2009-06, Vol.284 (23), p.15794-15804

2009

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First Genotype-Phenotype Study in TBX4 Syndrome: Gain-of-Function Mutations Causative for Lung Disease

American journal of respiratory and critical care medicine, 2022-12, Vol.206 (12), p.1522-1533

2022

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Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus

Cardiovascular research, 2021-09, Vol.117 (11), p.2309-2325

2021

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Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

EBioMedicine, 2020-06, Vol.56, p.102794-102794, Article 102794

2020

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Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells

PloS one, 2014-03, Vol.9 (3), p.e91334-e91334

2014

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High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

Scientific reports, 2023-04, Vol.13 (1), p.6639-6639, Article 6639

2023

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Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2

The Journal of biological chemistry, 2017-08, Vol.292 (33), p.13714-13726

2017

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Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension

Cardiovascular research, 2022-08, Vol.118 (11), p.2519-2534

2022

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Letter by Morrell et al Regarding Article, “Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension”

Circulation research, 2019-04, Vol.124 (9), p.e81-e81

2019

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Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3

American journal of respiratory cell and molecular biology, 2013-12, Vol.49 (6), p.1135-1145

2013

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4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension

American journal of respiratory cell and molecular biology, 2020-08, Vol.63 (2), p.160-171

2020

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Connexin-mediated regulation of the pulmonary vasculature

Biochemical Society transactions, 2015-06, Vol.43 (3), p.524

2015

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Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland

Preventive veterinary medicine, 2018-05, Vol.153, p.94-107

2018

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The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations

Human molecular genetics, 2013-09, Vol.22 (18), p.3667-3679

2013

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ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport

Cardiovascular research, 2024-05, Vol.120 (7), p.756-768

2024

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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia

Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension

An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

First Genotype-Phenotype Study in TBX4 Syndrome: Gain-of-Function Mutations Causative for Lung Disease

Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus

Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells

High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2

Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension

Letter by Morrell et al Regarding Article, “Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension”

Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3

4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension

Connexin-mediated regulation of the pulmonary vasculature

Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations

ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport

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