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Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Phosphopantetheinyl Transferases

Bioconjugate chemistry, 2015-12, Vol.26 (12), p.2554-2562

2015

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In vivo Incorporation of Unnatural Amino Acids to Probe Structure, Dynamics, and Ligand Binding in a Large Protein by Nuclear Magnetic Resonance Spectroscopy

Journal of the American Chemical Society, 2008-07, Vol.130 (29), p.9268-9281

2008

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Site-specific protein modifications through pyrroline-carboxy-lysine residues

Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (26), p.10437-10442

2011

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A Fully Integrated High-Throughput Screening Methodology for the Discovery of New Polyolefin Catalysts: Discovery of a New Class of High Temperature Single-Site Group (IV) Copolymerization Catalysts

Journal of the American Chemical Society, 2003-04, Vol.125 (14), p.4306-4317

2003

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D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine

Nature chemical biology, 2011-04, Vol.7 (8), p.528

2011

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Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library

Journal of the American Chemical Society, 2006-02, Vol.128 (7), p.2182-2183

2006

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A Combinatorial Approach to the Discovery of Efficient Cationic Peptoid Reagents for Gene Delivery

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (4), p.1517-1522

1998

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Simultaneous Purification and Site-Specific Modification of Pyrroline-Carboxy-Lysine Proteins

Chembiochem : a European journal of chemical biology, 2012-02, Vol.13 (3), p.364-366

2012

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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5675-5690

2013

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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5675-5690

2013

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Expanding the Scope of RNA Catalysis

Science (American Association for the Advancement of Science), 1994-06, Vol.264 (5167), p.1924-1927

1994

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Tuning a Protein‐Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation

Chembiochem : a European journal of chemical biology, 2018-04, Vol.19 (8), p.799-804

2018

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Optimization of an Enzymatic Antibody–Drug Conjugation Approach Based on Coenzyme A Analogs

Bioconjugate chemistry, 2017-07, Vol.28 (7), p.1906-1915

2017

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Site-specific labeling of proteins with NMR-active unnatural amino acids

Journal of biomolecular NMR, 2010, Vol.46 (1), p.89-100

2010

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Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (3), p.1090-1096

2016

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Syk inhibitors with high potency in presence of blood

Bioorganic & medicinal chemistry letters, 2014-05, Vol.24 (10), p.2278-2282

2014

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Hemolytic anemia caused by Babesia gibsoni infection in dogs

Journal of the American Veterinary Medical Association, 1991-09, Vol.199 (5), p.601

1991

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Site-Specific Dual Labeling of Proteins by Using Small Orthogonal Tags at Neutral pH

Chembiochem : a European journal of chemical biology, 2014-08, Vol.15 (12), p.1787-1791

2014

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Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (13), p.3897-3902

2010

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Verification of a Designed Intramolecular Hydrogen Bond in a Drug Scaffold by Nuclear Magnetic Resonance Spectroscopy

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.5875-5877

2007

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Phenyl Backbone-Derived P,O- and P,N-Ligands for Palladium/Ligand-Catalyzed Aminations of Aryl Bromides, Iodides, and Chlorides. Syntheses and Structures of (P,O) n -Palladium(II)Aryl(Br) Complexes

Organometallics, 1999-05, Vol.18 (10), p.1840-1853

1999

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Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4

Analytical biochemistry, 2009-09, Vol.392 (2), p.162-168

2009

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A convenient palladium/ligand catalyst for Suzuki cross-coupling reactions of arylboronic acids and aryl chlorides

Tetrahedron letters, 1999-05, Vol.40 (20), p.3855-3858

1999

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New submonomers for poly N-substituted glycines (peptoids)

Tetrahedron letters, 1999-02, Vol.40 (8), p.1475-1478

1999

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Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction

Journal of the American Chemical Society, 1994-03, Vol.116 (6), p.2261-2270

1994

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Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Phosphopantetheinyl Transferases

In vivo Incorporation of Unnatural Amino Acids to Probe Structure, Dynamics, and Ligand Binding in a Large Protein by Nuclear Magnetic Resonance Spectroscopy

Site-specific protein modifications through pyrroline-carboxy-lysine residues

A Fully Integrated High-Throughput Screening Methodology for the Discovery of New Polyolefin Catalysts: Discovery of a New Class of High Temperature Single-Site Group (IV) Copolymerization Catalysts

D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine

Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library

A Combinatorial Approach to the Discovery of Efficient Cationic Peptoid Reagents for Gene Delivery

Simultaneous Purification and Site-Specific Modification of Pyrroline-Carboxy-Lysine Proteins

Expanding the Scope of RNA Catalysis

Tuning a Protein‐Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation

Optimization of an Enzymatic Antibody–Drug Conjugation Approach Based on Coenzyme A Analogs

Site-specific labeling of proteins with NMR-active unnatural amino acids

Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors

Syk inhibitors with high potency in presence of blood

Hemolytic anemia caused by Babesia gibsoni infection in dogs

Site-Specific Dual Labeling of Proteins by Using Small Orthogonal Tags at Neutral pH

Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1

Verification of a Designed Intramolecular Hydrogen Bond in a Drug Scaffold by Nuclear Magnetic Resonance Spectroscopy

Phenyl Backbone-Derived P,O- and P,N-Ligands for Palladium/Ligand-Catalyzed Aminations of Aryl Bromides, Iodides, and Chlorides. Syntheses and Structures of (P,O) n -Palladium(II)Aryl(Br) Complexes

Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4

A convenient palladium/ligand catalyst for Suzuki cross-coupling reactions of arylboronic acids and aryl chlorides

New submonomers for poly N-substituted glycines (peptoids)

Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction

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