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On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis

Neurochemical research, 2014-10, Vol.39 (10), p.2008-2017

2014

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ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models

The Journal of pharmacology and experimental therapeutics, 2007-08, Vol.322 (2), p.862

2007

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Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7517-7519

2005

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Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Molecular pharmacology, 2008-01, Vol.73 (1), p.94

2008

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Optimization of isochromanone based urotensin II receptor agonists

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (13), p.4844-4854

2010

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Identification of novel subtype selective RAR agonists

Biochemical pharmacology, 2005-12, Vol.71 (1), p.156-162

2005

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Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2 mg/day, but does not enhance efficacy of haloperidol, 2 mg/day: Comparison with reference dose risperidone, 6 mg/day

Schizophrenia research, 2012-11, Vol.141 (2), p.144-152

2012

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Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: Comparison with reference dose risperidone, 6mg/day

Schizophrenia research, 2012-11, Vol.141 (2-3), p.144-152

2012

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Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist

The Journal of pharmacology and experimental therapeutics, 2004-09, Vol.310 (3), p.943

2004

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Stereoselective Epoxidation of Phe-Gly and Phe-Phe Vinyl Isosteres

Journal of organic chemistry, 1994-03, Vol.59 (5), p.1139-1148

1994

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Behavioral effects of clozapine, pimavanserin, and quetiapine in rodent models of Parkinson's disease and Parkinson's disease psychosis: evaluation of therapeutic ratios

Behavioural pharmacology, 2013-10, Vol.24 (7), p.628

2013

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The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons

Naunyn-Schmiedeberg's archives of pharmacology, 1993-04, Vol.347 (4), p.353-362

1993

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Discovery of an Ectopic Activation Site on the M 1 Muscarinic Receptor

Molecular pharmacology, 2002-06, Vol.61 (6), p.1297-1302

2002

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II. In vitro evidence that (−)-OSU6162 and (+)-OSU6162 produce their behavioral effects through 5-HT2A serotonin and D2 dopamine receptors

JOURNAL OF NEURAL TRANSMISSION, 2011-11, Vol.118 (11), p.1523-1533

2011

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Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1540-1545

2009

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Design, parallel synthesis and SAR of novel urotensin II receptor agonists

European journal of medicinal chemistry, 2007-02, Vol.42 (2), p.276-285

2007

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Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Journal of medicinal chemistry, 1999-04, Vol.42 (7), p.1115-1122

1999

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1 The Chemistry and Biochemistry of C-Nucleosides and C-Arylglycosides

Progress in Medicinal Chemistry, 1985, Vol.22, p.1-65

1985

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Analysis of molecular determinants of affinity and relative efficacy of a series of R ‐ and S ‐2‐(dipropylamino)tetralins at the 5‐HT 1A serotonin receptor

British journal of pharmacology, 2009-01, Vol.138 (6), p.1129-1139

2009

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Constitutively Active Mutants of the Histamine H 1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Molecular pharmacology, 2008-01, Vol.73 (1), p.94-103

2008

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Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2232-2240

2006

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Base-Catalyzed cyclization of N-propargylamides to oxazoles

Journal of heterocyclic chemistry, 1989-03, Vol.26 (2), p.269-275

1989

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8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist

Journal of medicinal chemistry, 1981-08, Vol.24 (8), p.921-923

1981

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3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

Journal of medicinal chemistry, 1995-02, Vol.38 (3), p.473-487

1995

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PET analysis of the 5-HT2A receptor inverse agonist ACP-103 in human brain

The international journal of neuropsychopharmacology, 2008-03, Vol.11 (2), p.163-171

2008

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On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis

ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models

Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist

Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Optimization of isochromanone based urotensin II receptor agonists

Identification of novel subtype selective RAR agonists

Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2 mg/day, but does not enhance efficacy of haloperidol, 2 mg/day: Comparison with reference dose risperidone, 6 mg/day

Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: Comparison with reference dose risperidone, 6mg/day

Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist

Stereoselective Epoxidation of Phe-Gly and Phe-Phe Vinyl Isosteres

Behavioral effects of clozapine, pimavanserin, and quetiapine in rodent models of Parkinson's disease and Parkinson's disease psychosis: evaluation of therapeutic ratios

The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons

Discovery of an Ectopic Activation Site on the M 1 Muscarinic Receptor

II. In vitro evidence that (−)-OSU6162 and (+)-OSU6162 produce their behavioral effects through 5-HT2A serotonin and D2 dopamine receptors

Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Design, parallel synthesis and SAR of novel urotensin II receptor agonists

Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

1 The Chemistry and Biochemistry of C-Nucleosides and C-Arylglycosides

Analysis of molecular determinants of affinity and relative efficacy of a series of R ‐ and S ‐2‐(dipropylamino)tetralins at the 5‐HT 1A serotonin receptor

Constitutively Active Mutants of the Histamine H 1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Base-Catalyzed cyclization of N-propargylamides to oxazoles

8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist

3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

PET analysis of the 5-HT2A receptor inverse agonist ACP-103 in human brain

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