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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

Circulation (New York, N.Y.), 2017-03, Vol.135 (12), p.1160-1173

2017

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TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Nature communications, 2017-01, Vol.8 (1), p.14079-14079, Article 14079

2017

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Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2

Circulation (New York, N.Y.), 2017-12, Vol.136 (25), p.2451-2467

2017

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BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia

American journal of human genetics, 2013-09, Vol.93 (3), p.530-537

2013

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Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension

American journal of respiratory and critical care medicine, 2019-04, Vol.199 (7), p.891-902

2019

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Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

American journal of respiratory and critical care medicine, 2021-06, Vol.203 (11), p.1419-1430

2021

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Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

The Journal of biological chemistry, 2009-06, Vol.284 (23), p.15794-15804

2009

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Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

EBioMedicine, 2020-06, Vol.56, p.102794-102794, Article 102794

2020

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High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

Scientific reports, 2023-04, Vol.13 (1), p.6639-6639, Article 6639

2023

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Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein

International journal of molecular sciences, 2021-10, Vol.22 (20), p.11282

2021

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Connexin-mediated regulation of the pulmonary vasculature

Biochemical Society transactions, 2015-06, Vol.43 (3), p.524-529

2015

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Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells

PloS one, 2014-03, Vol.9 (3), p.e91334-e91334

2014

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Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

Circulation research, 2005-05, Vol.96 (10), p.1053-1063

2005

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BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production

PloS one, 2012-01, Vol.7 (1), p.e30075

2012

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Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an “HHT‐like” syndrome in children

Molecular genetics & genomic medicine, 2021-12, Vol.9 (12), p.e1685-n/a

2021

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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

Nature medicine, 2015-07, Vol.21 (7), p.777-785

2015

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ETA and ETB Receptors Modulate the Proliferation of Human Pulmonary Artery Smooth Muscle Cells

American journal of respiratory and critical care medicine, 2002-02, Vol.165 (3), p.398-405

2002

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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Nature communications, 2018-04, Vol.9 (1), p.1416-16, Article 1416

2018

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An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis

Communications biology, 2022-11, Vol.5 (1), p.1192-15, Article 1192

2022

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Functional Characterization of Bone Morphogenetic Protein Binding Sites and Smad1/5 Activation in Human Vascular Cells

Molecular pharmacology, 2008-02, Vol.73 (2), p.539-552

2008

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Reduced circulating BMP9 and pBMP10 in hospitalized COVID‐19 patients

Pulmonary circulation, 2023-01, Vol.13 (1), p.e12192-n/a

2023

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An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension

Developmental dynamics, 2023-03, Vol.252 (3), p.327-342

2023

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Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

American journal of respiratory and critical care medicine, 2020-03, Vol.201 (5), p.575-585

2020

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Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

Communications biology, 2021-08, Vol.4 (1), p.1002-1002, Article 1002

2021

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Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus

Cardiovascular research, 2021-09, Vol.117 (11), p.2309-2325

2021

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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2

BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia

Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension

Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein

Connexin-mediated regulation of the pulmonary vasculature

Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells

Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production

Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an “HHT‐like” syndrome in children

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

ETA and ETB Receptors Modulate the Proliferation of Human Pulmonary Artery Smooth Muscle Cells

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis

Functional Characterization of Bone Morphogenetic Protein Binding Sites and Smad1/5 Activation in Human Vascular Cells

Reduced circulating BMP9 and pBMP10 in hospitalized COVID‐19 patients

An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus

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