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Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

Frontiers in endocrinology (Lausanne), 2012, Vol.3, p.111-111

Ulven, Trond

2012

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Complex Pharmacology of Free Fatty Acid Receptors

Chemical reviews, 2017-01, Vol.117 (1), p.67-110

2017

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Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

Journal of allergy and clinical immunology, 2019-09, Vol.144 (3), p.764-776

2019

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Oxalyl Chloride as a Practical Carbon Monoxide Source for Carbonylation Reactions

Organic letters, 2015-06, Vol.17 (11), p.2832-2835

2015

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Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

eLife, 2022-03, Vol.11

2022

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Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Cell reports (Cambridge), 2020-03, Vol.30 (9), p.2934-2947.e6

2020

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Discovery of a Potent and Selective GPR120 Agonist

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4511-4515

2012

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Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenanthroline-2,9-dicarboxamides

Organic letters, 2011-07, Vol.13 (13), p.3546-3548

2011

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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

Molecular pharmacology, 2013-11, Vol.84 (5), p.710-725

2013

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FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

Scientific reports, 2020-10, Vol.10 (1), p.16497-16497, Article 16497

2020

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The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)

The Journal of biological chemistry, 2014-07, Vol.289 (29), p.20345-20358

2014

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Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

Journal of neuroinflammation, 2017-04, Vol.14 (1), p.91-91, Article 91

2017

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Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice

Journal of lipid research, 2020-02, Vol.61 (2), p.133-142

2020

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Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

The Journal of biological chemistry, 2012-11, Vol.287 (49), p.41195-41209

2012

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Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4849-4858

2016

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Acute effects of delayed-release hydrolyzed pine nut oil on glucose tolerance, incretins, ghrelin and appetite in healthy humans

Clinical nutrition (Edinburgh, Scotland), 2021-04, Vol.40 (4), p.2169-2179

2021

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Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120

Molecular pharmacology, 2016-05, Vol.89 (5), p.505-520

2016

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Tetrasubstituted Phenanthrolines as Highly Potent, Water-Soluble, and Selective G-Quadruplex Ligands

Chemistry : a European journal, 2012-08, Vol.18 (35), p.10892-10902

2012

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The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

ChemSusChem, 2012-02, Vol.5 (2), p.274-277

2012

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Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

The Journal of biological chemistry, 2013-06, Vol.288 (24), p.17296-17312

2013

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Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5638-5645

2017

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The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

EMBO molecular medicine, 2018-03, Vol.10 (3), p.n/a

2018

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Fatty acid 16:4(n‐3) stimulates a GPR120‐induced signaling cascade in splenic macrophages to promote chemotherapy resistance

The FASEB journal, 2017-05, Vol.31 (5), p.2195-2209

2017

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The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

Journal of innate immunity, 2021-09, Vol.13 (4), p.242-256

2021

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Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands

The Journal of biological chemistry, 2016-01, Vol.291 (1), p.303-317

2016

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Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

Complex Pharmacology of Free Fatty Acid Receptors

Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

Oxalyl Chloride as a Practical Carbon Monoxide Source for Carbonylation Reactions

Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Discovery of a Potent and Selective GPR120 Agonist

Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenanthroline-2,9-dicarboxamides

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice

Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

Acute effects of delayed-release hydrolyzed pine nut oil on glucose tolerance, incretins, ghrelin and appetite in healthy humans

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120

Tetrasubstituted Phenanthrolines as Highly Potent, Water-Soluble, and Selective G-Quadruplex Ligands

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

Fatty acid 16:4(n‐3) stimulates a GPR120‐induced signaling cascade in splenic macrophages to promote chemotherapy resistance

The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands

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