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Pharmacological evaluation of TAK-828F, a novel orally available RORγt inverse agonist, on murine chronic experimental autoimmune encephalomyelitis model

Journal of neuroimmunology, 2019-10, Vol.335, p.577016-577016, Article 577016

2019

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Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease

Inflammation research, 2019-06, Vol.68 (6), p.493-509

2019

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Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells

Inflammation research, 2019-03, Vol.68 (3), p.223-230

2019

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Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

Inflammation, 2019-02, Vol.42 (1), p.91-102

2019

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MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model

International immunopharmacology, 2018-07, Vol.60, p.160-169

2018

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Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist

Biochemical pharmacology, 2018-04, Vol.150, p.35-45

2018

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Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by Fc?R signaling

International immunopharmacology, 2018-03, Vol.56, p.193

2018

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Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling

International immunopharmacology, 2018-03, Vol.56, p.193-196

2018

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Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain

Molecular pain, 2014-02, Vol.10 (1), p.15-15

2014

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Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice

International immunopharmacology, 2013-01, Vol.15 (1), p.23-29

2013

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TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules

Molecular pharmacology, 2011-01, Vol.79 (1), p.34-41

2011

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In Vitro and In Vivo Antifungal Activities of TAK-456, a Novel Oral Triazole with a Broad Antifungal Spectrum

Antimicrobial Agents and Chemotherapy, 2002-05, Vol.46 (5), p.1388-1393

2002

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サルモネラ菌は宿主の細胞内シグナル伝達分子を操る

ファルマシア, 2000/05/01, Vol.36(5), pp.414-415

土森, 登

2000

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Reduced Virulence of HWP1-Deficient Mutants of Candida albicans and Their Interactions with Host Cells

Infection and Immunity, 2000-04, Vol.68 (4), p.1997-2002

2000

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Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

Antimicrobial Agents and Chemotherapy, 1999-05, Vol.43 (5), p.1163-1169

1999

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Therapeutic effects of cefozopran against experimental mixed urinary tract infection with Enterococcus faecalis and Pseudomonas aeruginosa in mice

Journal of antimicrobial chemotherapy, 1997-03, Vol.39 (3), p.423-425

1997

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Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-[(1R, 2R)-2-(2, 4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-4-[4-(2, 2, 3, 3-tetrafluoropropoxy)phenyl]-3(2H, 4H)-1, 2, 4-triazolone (TAK-187)

Chemical and Pharmaceutical Bulletin, 1997/02/15, Vol.45(2), pp.321-326

1997

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Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187)

Chemical & pharmaceutical bulletin, 1997, Vol.45 (2), p.321-326

1997

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Penicillin-binding protein 5 as an inhibitory target of cefozopran in Enterococcus faecalis

Journal of antimicrobial chemotherapy, 1996-03, Vol.37 (3), p.605-609

1996

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Optically Active Antifungal Azoles. V. Synthesis and Antifungal Activity of Stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1, 2, 4-triazol-1-yl)-2-butanols

Chemical and Pharmaceutical Bulletin, 1995/03/15, Vol.43(3), pp.441-449

1995

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Crystal Structure of an Inhibitor of Starfish Embryonic Development, 4-Oxo-7-([beta]-D-ribofuranosyl)-3H-furo[3, 2-d]pyrimidine

Analytical sciences, 1992-11, Vol.8 (6), p.897

1992

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Crystal Structure of an Inhibitor of Starfish Embryonic Development, 4-Oxo-7-(β-D-ribofuranosyl)-3H-furo[3, 2-d]pyrimidine: Revision of Pyrrolosine Structure

Analytical Sciences, 1992/12/10, Vol.8(6), pp.897-898

1992

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Structure of pyrrolosine: a novel inhibitor of RNA synthesis, from the actinomycete Streptomyces albus

Journal of the American Chemical Society, 1990-12, Vol.112 (26), p.9668-9669

1990

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Significance of an Increase of Intracellular Adenosine Concentration for Dormancy in Starfish Blastulae

Development, growth & differentiation, 1988-10, Vol.30 (5), p.553-562

1988

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Pharmacological evaluation of TAK-828F, a novel orally available RORγt inverse agonist, on murine chronic experimental autoimmune encephalomyelitis model

Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease

Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist

Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by Fc?R signaling

Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling

Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain

Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice

TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules

In Vitro and In Vivo Antifungal Activities of TAK-456, a Novel Oral Triazole with a Broad Antifungal Spectrum

サルモネラ菌は宿主の細胞内シグナル伝達分子を操る

Reduced Virulence of HWP1-Deficient Mutants of Candida albicans and Their Interactions with Host Cells

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

Therapeutic effects of cefozopran against experimental mixed urinary tract infection with Enterococcus faecalis and Pseudomonas aeruginosa in mice

Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-[(1R, 2R)-2-(2, 4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-4-[4-(2, 2, 3, 3-tetrafluoropropoxy)phenyl]-3(2H, 4H)-1, 2, 4-triazolone (TAK-187)

Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187)

Penicillin-binding protein 5 as an inhibitory target of cefozopran in Enterococcus faecalis

Optically Active Antifungal Azoles. V. Synthesis and Antifungal Activity of Stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1, 2, 4-triazol-1-yl)-2-butanols

Crystal Structure of an Inhibitor of Starfish Embryonic Development, 4-Oxo-7-([beta]-D-ribofuranosyl)-3H-furo[3, 2-d]pyrimidine

Crystal Structure of an Inhibitor of Starfish Embryonic Development, 4-Oxo-7-(β-D-ribofuranosyl)-3H-furo[3, 2-d]pyrimidine: Revision of Pyrrolosine Structure

Structure of pyrrolosine: a novel inhibitor of RNA synthesis, from the actinomycete Streptomyces albus

Significance of an Increase of Intracellular Adenosine Concentration for Dormancy in Starfish Blastulae

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