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Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction

The FEBS journal, 2013-01, Vol.280 (2), p.346-378

Tonks, Nicholas K

2013

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Protein tyrosine phosphatases: from genes, to function, to disease

Nature reviews. Molecular cell biology, 2006-11, Vol.7 (11), p.833-846

Tonks, Nicholas K

2006

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Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow

IUBMB life, 2023-04, Vol.75 (4), p.337-352

Tonks, Nicholas K.

2023

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A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models

The Journal of biological chemistry, 2018-02, Vol.293 (5), p.1517-1525

2018

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H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response

Science signaling, 2011-12, Vol.4 (203), p.ra86

2011

Volltextzugriff (PDF)

Redox Redux: Revisiting PTPs and the Control of Cell Signaling

Cell, 2005-06, Vol.121 (5), p.667-670

Tonks, Nicholas K.

2005

Volltextzugriff (PDF)

PTP1B: From the sidelines to the front lines

FEBS Letters, 2003-07, Vol.546 (1), p.140-148

Tonks, Nicholas K.

2003

Volltextzugriff (PDF)

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

Cell, 2011-09, Vol.147 (1), p.185-198

2011

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Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

Nature (London), 2003-06, Vol.423 (6941), p.769-773

2003

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Comparison of calcaneal quantitative ultrasound and bone densitometry parameters as fracture risk predictors in type 2 diabetes mellitus

Diabetic medicine, 2020-11, Vol.37 (11), p.1902-1909

2020

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Combinatorial control of the specificity of protein tyrosine phosphatases

Current Opinion in Cell Biology, 2001-04, Vol.13 (2), p.182-195

2001

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Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (33), p.13398-13403

2013

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HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer

Genes & development, 2016-07, Vol.30 (13), p.1542-1557

2016

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Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence

Molecular cell, 2014-09, Vol.55 (5), p.782-790

2014

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Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

Nature communications, 2018-01, Vol.9 (1), p.283-17, Article 283

2018

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Protein-tyrosine Phosphatase 1B Antagonized Signaling by Insulin-like Growth Factor-1 Receptor and Kinase BRK/PTK6 in Ovarian Cancer Cells

The Journal of biological chemistry, 2013-08, Vol.288 (34), p.24923-24934

2013

Volltextzugriff (PDF)

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'

Genes & development, 2011-07, Vol.25 (13), p.1412-1425

2011

Volltextzugriff (PDF)

The use of phage display to generate conformation-sensor recombinant antibodies

Nature protocols, 2012-12, Vol.7 (12), p.2127-2143

2012

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Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

The Journal of biological chemistry, 2015-06, Vol.290 (26), p.15934-15947

2015

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Functional analysis of the protein phosphatase activity of PTEN

Biochemical journal, 2012-06, Vol.444 (3), p.457-464

2012

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Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action

Science translational medicine, 2013-01, Vol.5 (170), p.170ra14

2013

Volltextzugriff (PDF)

Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

Molecular and cellular biology, 2001-11, Vol.21 (21), p.7117-7136

2001

Volltextzugriff (PDF)

Molecular Basis for the Dephosphorylation of the Activation Segment of the Insulin Receptor by Protein Tyrosine Phosphatase 1B

Molecular cell, 2000-12, Vol.6 (6), p.1401-1412

2000

Volltextzugriff (PDF)

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity

Biochemical journal, 2015-01, Vol.465 (1), p.89-101

2015

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Protein Tyrosine Phosphatases in Cancer

1, 2016

Volltextzugriff (PDF)

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Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction

Protein tyrosine phosphatases: from genes, to function, to disease

Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow

A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models

H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response

Redox Redux: Revisiting PTPs and the Control of Cell Signaling

PTP1B: From the sidelines to the front lines

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

Comparison of calcaneal quantitative ultrasound and bone densitometry parameters as fracture risk predictors in type 2 diabetes mellitus

Combinatorial control of the specificity of protein tyrosine phosphatases

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling

HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer

Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

Protein-tyrosine Phosphatase 1B Antagonized Signaling by Insulin-like Growth Factor-1 Receptor and Kinase BRK/PTK6 in Ovarian Cancer Cells

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'

The use of phage display to generate conformation-sensor recombinant antibodies

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

Functional analysis of the protein phosphatase activity of PTEN

Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action

Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

Molecular Basis for the Dephosphorylation of the Activation Segment of the Insulin Receptor by Protein Tyrosine Phosphatase 1B

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity

Protein Tyrosine Phosphatases in Cancer

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