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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.460-472

2023

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Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

Journal of the American Chemical Society, 2018-05, Vol.140 (21), p.6596-6603

2018

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C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1569-1572

2010

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Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13546-13560

2020

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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5704-5718

2018

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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10879-10896

2020

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Discovery of a Clinical Candidate from the Structurally Unique Dioxa-bicyclo[3.2.1]octane Class of Sodium-Dependent Glucose Cotransporter 2 Inhibitors

Journal of medicinal chemistry, 2011-04, Vol.54 (8), p.2952-2960

2011

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Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3685-3696

2018

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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)

Journal of medicinal chemistry, 2017-09, Vol.60 (18), p.7835-7849

2017

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2372-2383

2018

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Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577

Organic process research & development, 2018-06, Vol.22 (6), p.681-696

2018

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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.854-865

2023

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2-[4-Chloro-3-(4-ethoxy-benz-yl)phen-yl]-1,3-dithiane

Acta crystallographica. Section E, Structure reports online, 2010-05, Vol.66 (Pt 6), p.o1386-o1386

2010

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

MedChemComm, 2013, Vol.4 (1), p.101-111

2013

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Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

Tetrahedron letters, 2010-04, Vol.51 (14), p.1880-1883

2010

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On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozinThis article is dedicated to professor Stephen Hanessian for his contribution to organic synthesis.This article is part of a MedChemComm 'New Talents' issue highlighting the work of outstanding rising scientists in medicinal chemistry research.Electronic supplementary information (ESI) available: X-ray crystallographic data for compound 33. CCDC 888909. For ESI and

2012-12

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Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up "One Health" research in the wake of emerging and re-emerging infectious diseases

PLoS neglected tropical diseases, 2022-02, Vol.16 (2), p.e0010193-e0010193

2022

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Colony size buffers interactions between neonicotinoid exposure and cold stress in bumblebees

Proceedings of the Royal Society. B, Biological sciences, 2023-07, Vol.290 (2003), p.20230555-20230555

2023

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Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

Journal of the American Chemical Society, 2017-03, Vol.139 (9), p.3528-3536

2017

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Long-term tracking and quantification of individual behavior in bumble bee colonies

Artificial life and robotics, 2022-05, Vol.27 (2), p.401-406

2022

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Characterization of Asialoglycoprotein Receptor (ASGPR) Directed Hepatocellular Delivery Using a Pfizer Developed Targeting Ligand PF‐06853291

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Association between malaria control and paediatric blood transfusions in rural Zambia: an interrupted time-series analysis

Malaria journal, 2014-09, Vol.13 (1), p.383-383, Article 383

2014

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Receptor‐Mediated Delivery of CRISPR‐Cas9 Endonuclease for Cell Type Specific Gene Editing

The FASEB journal, 2018-04, Vol.32 (S1), p.649.2-649.2

2018

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Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin

Organic process research & development, 2014-01, Vol.18 (1), p.57-65

2014

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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Discovery of a Clinical Candidate from the Structurally Unique Dioxa-bicyclo[3.2.1]octane Class of Sodium-Dependent Glucose Cotransporter 2 Inhibitors

Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

2-[4-Chloro-3-(4-ethoxy-benz-yl)phen-yl]-1,3-dithiane

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up "One Health" research in the wake of emerging and re-emerging infectious diseases

Colony size buffers interactions between neonicotinoid exposure and cold stress in bumblebees

Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

Long-term tracking and quantification of individual behavior in bumble bee colonies

Characterization of Asialoglycoprotein Receptor (ASGPR) Directed Hepatocellular Delivery Using a Pfizer Developed Targeting Ligand PF‐06853291

Association between malaria control and paediatric blood transfusions in rural Zambia: an interrupted time-series analysis

Receptor‐Mediated Delivery of CRISPR‐Cas9 Endonuclease for Cell Type Specific Gene Editing

Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin

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