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Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

Biological psychiatry (1969), 2018-11, Vol.84 (10), p.722-733

2018

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The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

British journal of pharmacology, 2016-08, Vol.173 (16), p.2506-2520

2016

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Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Journal of neuroinflammation, 2021-04, Vol.18 (1), p.99-99, Article 99

2021

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Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10820

2022

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Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors

PloS one, 2014-10, Vol.9 (10), p.e109115-e109115

2014

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Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

Molecules (Basel, Switzerland), 2020-01, Vol.25 (2), p.417

2020

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Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

Neuropharmacology, 2021-06, Vol.190, p.108553, Article 108553

2021

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Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

Frontiers in molecular neuroscience, 2020-04, Vol.13, p.54-54

2020

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Small molecule inhibitors of PSD95-nNOS protein–protein interactions as novel analgesics

Neuropharmacology, 2015-10, Vol.97, p.464-475

2015

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The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal

Experimental neurology, 2019-10, Vol.320, p.113010-113010, Article 113010

2019

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The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Molecular pain, 2012-09, Vol.8 (1), p.71-71

2012

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Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

Frontiers in neuroscience, 2023-06, Vol.17, p.1196786-1196786

2023

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Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels

Pain (Amsterdam), 2012-05, Vol.153 (5), p.1091-1106

2012

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Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Frontiers in pharmacology, 2022-10, Vol.13, p.919605-919605

2022

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Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

The Journal of pharmacology and experimental therapeutics, 2008-11, Vol.327 (2), p.584

2008

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Prophylactic Cannabinoid Administration Blocks the Development of Paclitaxel-Induced Neuropathic Nociception during Analgesic Treatment and following Cessation of Drug Delivery

Molecular pain, 2014-04, Vol.10 (1), p.27-27

2014

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Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

Brain and behavior, 2020-12, Vol.10 (12), p.e01850-n/a

2020

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Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects

Pharmacology, biochemistry and behavior, 2011-06, Vol.98 (4), p.493-502

2011

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Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Frontiers in molecular neuroscience, 2019-10, Vol.12, p.257-257

2019

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Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives

Journal of organic chemistry, 2017-01, Vol.82 (2), p.992-999

2017

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Conformationally constrained analogs of BAY 59–3074 as novel cannabinoid receptor ligands

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5999-6002

2011

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The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

IBRO neuroscience reports, 2022-06, Vol.12, p.121-130

2022

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Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance

European journal of pharmaceutics and biopharmaceutics, 2019-03, Vol.136, p.18-28

2019

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C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5322-5325

2012

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The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Antioxidants, 2021-01, Vol.10 (1), p.135

2021

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Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors

Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

Small molecule inhibitors of PSD95-nNOS protein–protein interactions as novel analgesics

The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal

The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

Prophylactic Cannabinoid Administration Blocks the Development of Paclitaxel-Induced Neuropathic Nociception during Analgesic Treatment and following Cessation of Drug Delivery

Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects

Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives

Conformationally constrained analogs of BAY 59–3074 as novel cannabinoid receptor ligands

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance

C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

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