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PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction

Journal of lipid research, 2018-02, Vol.59 (2), p.207-223

2018

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Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosis Development

Arteriosclerosis, thrombosis, and vascular biology, 2020-12, Vol.40 (12), p.e322

2020

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A Critical Role of PCSK9 in Mediating IL-17-Producing T Cell Responses in Hyperlipidemia

Immune Network, 2019, 19(6), , pp.1-16

2019

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Fortilin reduces apoptosis in macrophages and promotes atherosclerosis

American journal of physiology. Heart and circulatory physiology, 2013-11, Vol.305 (10), p.H1519-H1529

2013

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Non-Native Conformational Isomers of the Catalytic Domain of PCSK9 Induce an Immune Response, Reduce Lipids and Increase LDL Receptor Levels

International journal of molecular sciences, 2018-02, Vol.19 (2), p.640

2018

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Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor

Arteriosclerosis, thrombosis, and vascular biology, 2012-07, Vol.32 (7), p.1585

2012

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Proatherogenic Conditions Promote Autoimmune T Helper 17 Cell Responses In Vivo

Immunity (Cambridge, Mass.), 2014-01, Vol.40 (1), p.153-165

2014

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Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia

Arteriosclerosis, thrombosis, and vascular biology, 2015-08, Vol.35 (8), p.1787

2015

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Modulation of Muscle Regeneration, Myogenesis, and Adipogenesis by the Rho Family Guanine Nucleotide Exchange Factor GEFT

Molecular and Cellular Biology, 2005-12, Vol.25 (24), p.11089-11101

2005

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Renal Expression of the C3a Receptor and Functional Responses of Primary Human Proximal Tubular Epithelial Cells

The Journal of immunology (1950), 2004-09, Vol.173 (6), p.4190-4196

2004

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Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice

Molecular therapy. Nucleic acids, 2013-10, Vol.2 (10), p.e125-e125, Article e125

2013

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Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice

American journal of physiology. Heart and circulatory physiology, 2012-01, Vol.302 (2), p.H451-H458

2012

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Differential expression of genes in the calcium-signaling pathway underlies lesion development in the LDb mouse model of atherosclerosis

Atherosclerosis, 2010-11, Vol.213 (1), p.40-51

2010

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The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase

The Journal of biological chemistry, 1993-10, Vol.268 (28), p.20709-20712

1993

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Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1): structure–function relationships of RNA editing and dimerization

Journal of lipid research, 1999-04, Vol.40 (4), p.623-635

1999

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Tissue-specific Inhibition of Apolipoprotein B mRNA Editing in the Liver by Adenovirus-mediated Transfer of a Dominant Negative Mutant APOBEC-1 Leads to Increased Low Density Lipoprotein in Mice

The Journal of biological chemistry, 1997-01, Vol.272 (3), p.1456-1460

1997

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Hammerhead Ribozyme Cleavage of Apolipoprotein B mRNA Generates a Truncated Protein

The Journal of biological chemistry, 1999-08, Vol.274 (34), p.24161-24170

1999

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Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes

Atherosclerosis, 2003-07, Vol.169 (1), p.51-62

2003

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Increased plasma non-esterified fatty acids and platelet-activating factor acetylhydrolase are associated with susceptibility to atherosclerosis in mice

Clinical science (1979), 2004-04, Vol.106 (4), p.421

2004

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Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection

Biochemical and biophysical research communications, 2006-04, Vol.342 (3), p.782-790

2006

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Maximum Immunobioactivity of Murine Small Intestinal Intraepithelial Lymphocytes Resides in a Subpopulation of CD43+ T Cells

The Journal of immunology (1950), 2004-11, Vol.173 (10), p.6294-6302

2004

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Paradoxical upregulation of tumor suppressor protein p53 in serum-stimulated vascular smooth muscle cells: a novel negative-feedback regulatory mechanism

Circulation (New York, N.Y.), 2003-07, Vol.108 (4), p.464-471

2003

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Simultaneous expression of apolipoprotein B mRNA editing enzyme and scavenger receptor BI mediated by a therapeutic gene expression system

Atherosclerosis, 2006-02, Vol.184 (2), p.264-275

2006

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K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors : effects of supplemental dietary calcium and vitamin D deficiency

Cancer research (Chicago, Ill.), 1991-08, Vol.51 (16), p.4305-4309

1991

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Abstract 12151: PCSK9 Mediates Atherogenesis

Circulation (New York, N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A12151-A12151

2016

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PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction

Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosis Development

A Critical Role of PCSK9 in Mediating IL-17-Producing T Cell Responses in Hyperlipidemia

Fortilin reduces apoptosis in macrophages and promotes atherosclerosis

Non-Native Conformational Isomers of the Catalytic Domain of PCSK9 Induce an Immune Response, Reduce Lipids and Increase LDL Receptor Levels

Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor

Proatherogenic Conditions Promote Autoimmune T Helper 17 Cell Responses In Vivo

Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia

Modulation of Muscle Regeneration, Myogenesis, and Adipogenesis by the Rho Family Guanine Nucleotide Exchange Factor GEFT

Renal Expression of the C3a Receptor and Functional Responses of Primary Human Proximal Tubular Epithelial Cells

Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice

Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice

Differential expression of genes in the calcium-signaling pathway underlies lesion development in the LDb mouse model of atherosclerosis

The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase

Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1): structure–function relationships of RNA editing and dimerization

Tissue-specific Inhibition of Apolipoprotein B mRNA Editing in the Liver by Adenovirus-mediated Transfer of a Dominant Negative Mutant APOBEC-1 Leads to Increased Low Density Lipoprotein in Mice

Hammerhead Ribozyme Cleavage of Apolipoprotein B mRNA Generates a Truncated Protein

Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes

Increased plasma non-esterified fatty acids and platelet-activating factor acetylhydrolase are associated with susceptibility to atherosclerosis in mice

Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection

Maximum Immunobioactivity of Murine Small Intestinal Intraepithelial Lymphocytes Resides in a Subpopulation of CD43+ T Cells

Paradoxical upregulation of tumor suppressor protein p53 in serum-stimulated vascular smooth muscle cells: a novel negative-feedback regulatory mechanism

Simultaneous expression of apolipoprotein B mRNA editing enzyme and scavenger receptor BI mediated by a therapeutic gene expression system

K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors : effects of supplemental dietary calcium and vitamin D deficiency

Abstract 12151: PCSK9 Mediates Atherogenesis

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