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Application of Multi-component Reactions in the Search of Bioactive Molecules

Mini-reviews in organic chemistry, 2022-12, Vol.19 (8), p.894-897

2022

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Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

European journal of medicinal chemistry, 2021-12, Vol.226, p.113848-113848, Article 113848

2021

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Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators

RSC medicinal chemistry, 2023-07, Vol.14 (7), p.1272-1295

2023

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pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy

Bioactive materials, 2024-04, Vol.34, p.414-421

2024

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Exploiting Albumin as a Versatile Carrier for Cancer Theranostics

Accounts of chemical research, 2023-09, Vol.56 (18), p.2403-2415

2023

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Discovery of new inhibitors of Cdc25B phosphatases by molecular docking-based virtual screening

Journal of molecular structure, 2024-03, Vol.1299, p.137161, Article 137161

2024

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Medicinal chemistry insights into novel CDC25 inhibitors

European journal of medicinal chemistry, 2020-09, Vol.201, p.112374-112374, Article 112374

2020

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Targeted Radionuclide Therapy in Glioblastoma

ACS applied materials & interfaces, 2024-08, Vol.16 (31), p.40391-40410

2024

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The Quinone-Derived Small Molecule M5N32 Is an Effective Anti-Helicobacter pylori Agent Both In Vivo and In Vitro

The Journal of infectious diseases, 2022-12, Vol.226 (Suppl 5), p.S493-S502

2022

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Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4218-4237

2022

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Discovery of Bioactive Molecules via Miniaturized Parallel Modular Reactions and Rapid Screening (2016-2021 Update)

Mini-reviews in organic chemistry, 2022-08, Vol.19 (5), p.546-548

2022

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HIV-1 capsid inhibitors: a sword to destroy the virus

Future medicinal chemistry, 2022-05, Vol.14 (9), p.605-607

2022

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Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors

European journal of medicinal chemistry, 2021-12, Vol.225, p.113769-113769, Article 113769

2021

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Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries

Bioorganic chemistry, 2021-10, Vol.115, p.105254-105254, Article 105254

2021

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Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability

European journal of medicinal chemistry, 2022-01, Vol.227, p.113903-113903, Article 113903

2022

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From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

Chinese chemical letters, 2023-03, Vol.34 (3), p.107611, Article 107611

2023

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Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study

Acta pharmaceutica Sinica. B, 2024-05

2024

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Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Science (American Association for the Advancement of Science), 2020-05, Vol.368 (6492), p.779-782

2020

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Architecture of a SARS-CoV-2 mini replication and transcription complex

Nature communications, 2020-11, Vol.11 (1), p.5874-5874, Article 5874

2020

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Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

Cell, 2021-06, Vol.184 (13), p.3474-3485.e11

2021

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Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

Cell, 2021-01, Vol.184 (1), p.184-193.e10

2021

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A Novel Betulinic Acid Analogue: Synthesis, Solubility, Antitumor Activity and Pharmacokinetic Study in Rats

Molecules (Basel, Switzerland), 2023-07, Vol.28 (15), p.5715

2023

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All-in-one surface engineering strategy on nickel phosphide arrays towards a robust electrocatalyst for hydrogen evolution reaction

Journal of power sources, 2019-07, Vol.429, p.46-54

2019

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Functional molecule-mediated assembled copper nanozymes for diabetic wound healing

Journal of nanobiotechnology, 2023-08, Vol.21 (1), p.1-294, Article 294

2023

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High-temperature rheological behavior and non-isothermal pyrolysis mechanism of macerals separated from different coals

Energy (Oxford), 2023-08, Vol.277, p.127752, Article 127752

2023

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Application of Multi-component Reactions in the Search of Bioactive Molecules

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators

pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy

Exploiting Albumin as a Versatile Carrier for Cancer Theranostics

Discovery of new inhibitors of Cdc25B phosphatases by molecular docking-based virtual screening

Medicinal chemistry insights into novel CDC25 inhibitors

Targeted Radionuclide Therapy in Glioblastoma

The Quinone-Derived Small Molecule M5N32 Is an Effective Anti-Helicobacter pylori Agent Both In Vivo and In Vitro

Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability

Discovery of Bioactive Molecules via Miniaturized Parallel Modular Reactions and Rapid Screening (2016-2021 Update)

HIV-1 capsid inhibitors: a sword to destroy the virus

Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors

Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Architecture of a SARS-CoV-2 mini replication and transcription complex

Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

A Novel Betulinic Acid Analogue: Synthesis, Solubility, Antitumor Activity and Pharmacokinetic Study in Rats

All-in-one surface engineering strategy on nickel phosphide arrays towards a robust electrocatalyst for hydrogen evolution reaction

Functional molecule-mediated assembled copper nanozymes for diabetic wound healing

High-temperature rheological behavior and non-isothermal pyrolysis mechanism of macerals separated from different coals

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