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Localization and Quantification of Drugs in Animal Tissues by Use of Desorption Electrospray Ionization Mass Spectrometry Imaging

Analytical chemistry (Washington), 2012-06, Vol.84 (12), p.5439-5445

2012

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The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles

Drug metabolism letters, 2021, Vol.14 (2), p.126-136

2021

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Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Nature structural & molecular biology, 2017-02, Vol.24 (2), p.108-113

2017

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Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4320-4342

2013

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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2794-2809

2016

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Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

Molecular pain, 2016, Vol.12

2016

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Whole-body tissue distribution study of drugs in neonate mice using desorption electrospray ionization mass spectrometry imaging

Rapid communications in mass spectrometry, 2014-01, Vol.28 (2), p.185-190

2014

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Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2417-2430

2015

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Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Journal of medicinal chemistry, 2008-05, Vol.51 (10), p.2879-2882

2008

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ASSESSMENT OF MARKETING CHALLENGES AND OPPORTUNITIES OF BRANDED AGRICULTURAL PRODUCTS: THE CASE OF NORTH SHOA ZONE

Innovative issues and approaches in social sciences, 2018-09, Vol.11 (3), p.67

2018

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A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation

Drug metabolism and disposition, 2008-09, Vol.36 (9), p.1740-1744

2008

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Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.525-532

2007

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Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes

Drug metabolism and disposition, 2005-01, Vol.33 (1), p.121-130

2005

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Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice

Analytical and bioanalytical chemistry, 2013-03, Vol.405 (8), p.2635-2642

2013

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Application of on-line nano-liquid chromatography/mass spectrometry in metabolite identification studies

Rapid communications in mass spectrometry, 2012-02, Vol.26 (3), p.320-326

2012

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The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1105-1125

2017

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Species difference in glucuronidation formation kinetics with a selective mTOR inhibitor

Drug metabolism and disposition, 2014-04, Vol.42 (4), p.707-717

2014

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Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat

Drug metabolism and disposition, 2006-08, Vol.34 (8), p.1367-1375

2006

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Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10003-10015

2013

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Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3688-3691

2008

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

Journal of medicinal chemistry, 2012-07, Vol.55 (14), p.6523-6540

2012

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Desorption electrospray ionization tissue imaging using heated nebulizing gas and high-resolution accurate mass spectra: Tissue imaging with DESI using HRMS

Rapid communications in mass spectrometry, 2010-08, Vol.24 (16), p.2352-2356

2010

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Whole-body tissue distribution study of drugs in neonate mice using desorption electrospray ionization mass spectrometry imaging: Whole-body tissue distribution study by DESI-MSI

Rapid communications in mass spectrometry, 2014-01, Vol.28 (2), p.185-190

2014

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Essential and Non-Essential Metal Exposure Affects Gut Bacterial Composition in a Sample of the Wisconsin Population

Teffera, Menna Yohannes

2024

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Localization and Quantification of Drugs in Animal Tissues by Use of Desorption Electrospray Ionization Mass Spectrometry Imaging

The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity

Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

Whole-body tissue distribution study of drugs in neonate mice using desorption electrospray ionization mass spectrometry imaging

Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

ASSESSMENT OF MARKETING CHALLENGES AND OPPORTUNITIES OF BRANDED AGRICULTURAL PRODUCTS: THE CASE OF NORTH SHOA ZONE

A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation

Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs

Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes

Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice

Application of on-line nano-liquid chromatography/mass spectrometry in metabolite identification studies

The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors

Species difference in glucuronidation formation kinetics with a selective mTOR inhibitor

Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat

Discovery of (R)‑6-(1-(8-Fluoro-6-(1-methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)‑one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity

Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

Desorption electrospray ionization tissue imaging using heated nebulizing gas and high-resolution accurate mass spectra: Tissue imaging with DESI using HRMS

Whole-body tissue distribution study of drugs in neonate mice using desorption electrospray ionization mass spectrometry imaging: Whole-body tissue distribution study by DESI-MSI

Essential and Non-Essential Metal Exposure Affects Gut Bacterial Composition in a Sample of the Wisconsin Population

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