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Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1749-1752

2001

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NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.193-199

2004

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Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels

Bioorganic & medicinal chemistry, 2005-01, Vol.13 (1), p.141-155

2005

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6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

Journal of medicinal chemistry, 2002-09, Vol.45 (19), p.4171-4187

2002

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Synthesis of the first 1-azaanalogues of L-sugars

Tetrahedron, 1997-01, Vol.53 (2), p.697-706

1997

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Synthesis of the 2-Deoxyisomaltose Analogue of Acarbose by an Improved Route to Chiral Valieneamines

Chemistry : a European journal, 1997-03, Vol.3 (3), p.453-462

1997

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Synthesis of a new potent α-fucosidase inhibitor

Chemical communications (Cambridge, England), 1996 (23), p.2649-2650

1996

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ChemInform Abstract: Synthesis of the 2-Deoxyisomaltose Analogue of Acarbose by an Improved Route to Chiral Valieneamines

ChemInform, 1997-06, Vol.28 (23), p.no-no

1997

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ChemInform Abstract: Synthesis of a New Potent α-Fucosidase Inhibitor

ChemInform, 1997-05, Vol.28 (21), p.no-no

1997

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ChemInform Abstract: Synthesis of the First 1-Azaanalogues of L-Sugars

ChemInform, 1997-04, Vol.28 (18), p.no-no

1997

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Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.8942-8950

2021

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Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.616-628

2021

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Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2633-2645

2022

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Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

RSC chemical biology, 2024-07, Vol.5 (8), p.763-775

2024

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Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex

Acta crystallographica. Section D, Biological crystallography., 2014-02, Vol.70 (2), p.451-460

2014

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IMI European Lead Factory - democratizing access to high-throughput screening

Nature reviews. Drug discovery, 2022-04, Vol.21 (4), p.245-246

2022

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Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System

Annual Reports in Medicinal Chemistry, 2013, Vol.48, p.37-55

2013

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The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.177-180

2014

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Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase

Assay and drug development technologies, 2015-10, Vol.13 (8), p.466-475

2015

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Homology Modeling of the Serotonin Transporter: Insights into the Primary Escitalopram-binding Site

ChemMedChem, 2007-06, Vol.2 (6), p.815-826

2007

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Arylcyanoguanidines as Activators of Kir6.2/SUR1KATP Channels and Inhibitors of Insulin Release

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3202-3211

2004

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Molecular Dynamics Simulations of Na+/Cl−-Dependent Neurotransmitter Transporters in a Membrane-Aqueous System

ChemMedChem, 2007-06, Vol.2 (6), p.827-840

2007

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Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3202-3211

2004

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Synthesis and pharmacological evaluation of 4 H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels

Bioorganic & medicinal chemistry, 2005, Vol.13 (1), p.141-155

2005

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6-Chloro-3-alkylamino-4 H -thieno[3,2 -e ]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

Journal of medicinal chemistry, 2002-09, Vol.45 (19), p.4171-4187

2002

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Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels

Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels

6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

Synthesis of the first 1-azaanalogues of L-sugars

Synthesis of the 2-Deoxyisomaltose Analogue of Acarbose by an Improved Route to Chiral Valieneamines

Synthesis of a new potent α-fucosidase inhibitor

ChemInform Abstract: Synthesis of the 2-Deoxyisomaltose Analogue of Acarbose by an Improved Route to Chiral Valieneamines

ChemInform Abstract: Synthesis of a New Potent α-Fucosidase Inhibitor

ChemInform Abstract: Synthesis of the First 1-Azaanalogues of L-Sugars

Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans

Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320

Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates

Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex

IMI European Lead Factory - democratizing access to high-throughput screening

Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System

The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase

Homology Modeling of the Serotonin Transporter: Insights into the Primary Escitalopram-binding Site

Arylcyanoguanidines as Activators of Kir6.2/SUR1KATP Channels and Inhibitors of Insulin Release

Molecular Dynamics Simulations of Na+/Cl−-Dependent Neurotransmitter Transporters in a Membrane-Aqueous System

Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release

Synthesis and pharmacological evaluation of 4 H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels

6-Chloro-3-alkylamino-4 H -thieno[3,2 -e ]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

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