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Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Frontiers in pediatrics, 2020-06, Vol.8, p.307-307

2020

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Influence of betahistine repeated administration on a weight gain and selected metabolic parameters in the model of excessive eating in rats

Biomedicine & pharmacotherapy, 2021-09, Vol.141, p.111892-111892, Article 111892

2021

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The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia

International journal of molecular sciences, 2021-08, Vol.22 (15), p.7816

2021

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Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies

Neuropharmacology, 2019-11, Vol.158, p.107733, Article 107733

2019

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Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies

Psychopharmacology, 2021-11, Vol.238 (11), p.3167-3181

2021

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Guanabenz—an old drug with a potential to decrease obesity

Naunyn-Schmiedeberg's archives of pharmacology, 2022-08, Vol.395 (8), p.963-974

2022

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The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition

Behavioural brain research, 2024-02, Vol.457, p.114729-114729, Article 114729

2024

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Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice

International journal of molecular sciences, 2022-11, Vol.23 (21), p.13439

2022

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In silico and in vitro ADME-Tox analysis and in vivo pharmacokinetic study of representative pan-PDE inhibitors from the group of 7,8-disubstituted derivatives of 1,3-dimethyl-7H-purine-2,6-dione

Toxicology and applied pharmacology, 2022-12, Vol.457, p.116318, Article 116318

2022

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Metabolic benefits of novel histamine H3 receptor ligands in the model of excessive eating: The importance of intrinsic activity and pharmacokinetic properties

Biomedicine & pharmacotherapy, 2021-10, Vol.142, p.111952, Article 111952

2021

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Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides

International journal of molecular sciences, 2021-12, Vol.22 (23), p.13092

2021

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TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice

Cellular and molecular life sciences : CMLS, 2023-05, Vol.80 (5), p.133-133, Article 133

2023

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PSB 603 – a known selective adenosine A2B receptor antagonist – has anti-inflammatory activity in mice

Biomedicine & pharmacotherapy, 2021-03, Vol.135, p.111164, Article 111164

2021

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The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling

Journal of psychopharmacology (Oxford), 2020-12, Vol.34 (12), p.1431-1442

2020

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Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice

Frontiers in pharmacology, 2022-08, Vol.13, p.933364-933364

2022

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Discovery of (R)‑N‑Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS‑1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo

Journal of medicinal chemistry, 2022-09, Vol.65 (17), p.11703-11725

2022

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The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects

Pharmaceuticals (Basel, Switzerland), 2021-08, Vol.14 (8), p.799

2021

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KD-64—A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist—Caffeine does not reduce diet-induced obesity in mice

PloS one, 2020-06, Vol.15 (6), p.e0229806-e0229806

2020

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KSK19 – Novel histamine H3 receptor ligand reduces body weight in diet induced obese mice

Biochemical pharmacology, 2019-10, Vol.168, p.193-203

2019

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Evaluation of Some Safety Parameters of Dual Histamine H3 and Sigma-2 Receptor Ligands with Anti-Obesity Potential

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7499

2023

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Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating

Pharmaceuticals (Basel, Switzerland), 2021-03, Vol.14 (3), p.270

2021

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Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice

Neurotoxicity research, 2018-10, Vol.34 (3), p.333-346

2018

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Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome

Metabolites, 2023-11, Vol.13 (11), p.1130

2023

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Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive TherapiesIn Vitro and In Vivo Characterization

ACS chemical neuroscience, 2024-06, Vol.15 (11), p.2198-2222

2024

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KSK-74: Dual Histamine H3 and Sigma-2 Receptor Ligand with Anti-Obesity Potential

International journal of molecular sciences, 2022-06, Vol.23 (13), p.7011

2022

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Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Influence of betahistine repeated administration on a weight gain and selected metabolic parameters in the model of excessive eating in rats

The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia

Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies

Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies

Guanabenz—an old drug with a potential to decrease obesity

The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition

Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice

In silico and in vitro ADME-Tox analysis and in vivo pharmacokinetic study of representative pan-PDE inhibitors from the group of 7,8-disubstituted derivatives of 1,3-dimethyl-7H-purine-2,6-dione

Metabolic benefits of novel histamine H3 receptor ligands in the model of excessive eating: The importance of intrinsic activity and pharmacokinetic properties

Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides

TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice

PSB 603 – a known selective adenosine A2B receptor antagonist – has anti-inflammatory activity in mice

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling

Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice

Discovery of (R)‑N‑Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS‑1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects

KD-64—A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist—Caffeine does not reduce diet-induced obesity in mice

KSK19 – Novel histamine H3 receptor ligand reduces body weight in diet induced obese mice

Evaluation of Some Safety Parameters of Dual Histamine H3 and Sigma-2 Receptor Ligands with Anti-Obesity Potential

Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating

Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice

Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome

Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive TherapiesIn Vitro and In Vivo Characterization

KSK-74: Dual Histamine H3 and Sigma-2 Receptor Ligand with Anti-Obesity Potential

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