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Small-Molecule Ghrelin Receptor Antagonists Improve Glucose Tolerance, Suppress Appetite, and Promote Weight Loss

Endocrinology (Philadelphia), 2007-11, Vol.148 (11), p.5175-5185

2007

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Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

Journal of medicinal chemistry, 2014-12, Vol.57 (24), p.10512-10526

2014

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PDE-10A inhibitors as insulin secretagogues

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2869-2873

2007

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Raymond L. Erikson (1936–2020)

Molecular cell, 2020-06, Vol.78 (6), p.988-990

2020

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Raymond L. Erikson (1936–2020)

Cell, 2020-05, Vol.181 (5), p.961-963

2020

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Synthesis, Structure, and Biological Activity of a New Insulinomimetic Peroxovanadium Compound: Bisperoxovanadium Imidazole Monoanion

Journal of the American Chemical Society, 1997-06, Vol.119 (23), p.5447-5448

1997

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Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

Journal of medicinal chemistry, 2014-12, Vol.57 (24)

2014

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Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

MedChemComm, 2011-09, Vol.2 (9), p.828

2011

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Discovery of ( S )-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1 H -imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Journal of medicinal chemistry, 2012-02, Vol.55 (3), p.1318-1333

2012

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Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis

Diabetes (New York, N.Y.), 1998-03, Vol.47 (3), p.493

1998

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Indanylacetic acids as PPAR-δ activator insulin sensitizers

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4369-4373

2007

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Alteration of intramolecular disulfides in insulin receptor/kinase by insulin and dithiothreitol: insulin potentiates the apparent dithiothreitol-dependent subunit reduction of insulin receptor

Biochemistry (Easton), 1986-07, Vol.25 (15), p.4381-4388

1986

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Incorporation of the purified human placental insulin receptor into phospholipid vesicles

Biochemistry (Easton), 1985-11, Vol.24 (23), p.6571-6580

1985

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Substituted indanylacetic acids as PPAR-α–γ activators

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.297-301

2006

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Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzo f uran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

MedChemComm, 2011-01, Vol.2 (9), p.828-839

2011

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Dithiothreitol activation of the insulin receptor/kinase does not involve subunit dissociation of the native .alpha.2.beta.2 insulin receptor subunit complex

Biochemistry (Easton), 1986-11, Vol.25 (22), p.7068-7074

1986

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Two distinct enzymes contribute to biphasic S6 phosphorylation in serum-stimulated chicken embryo fibroblasts

Molecular and Cellular Biology, 1990-06, Vol.10 (6), p.2787-2792

1990

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Coinfection of Insect Cells with Recombinant Baculovirus Expressing pp60v-srcResults in the Activation of a Serine-Specific Protein Kinase pp90rsk

Proceedings of the National Academy of Sciences - PNAS, 1990-04, Vol.87 (7), p.2685-2689

1990

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Phospholipid activation of the insulin receptor kinase: regulation by phosphatidylinositol

The FASEB journal, 1987-07, Vol.1 (1), p.55-59

1987

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CHARACTERIZATION OF THE PURIFIED AND RECONSTITUTED INSULIN RECEPTOR

SWEET, LAUREL JEAN

1985

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ProQuest

Two Distinct Enzymes Contribute to Biphasic S6 Phosphorylation in Serum-Stimulated Chicken Embryo Fibroblasts

Molecular and cellular biology, 1990-06, Vol.10 (6), p.2787-2792

1990

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Transfer of functional insulin receptors to receptor-deficient target cells

Endocrinology (Philadelphia), 1988-06, Vol.122 (6), p.2865-2872

1988

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Identification of Mitogen-Responsive Ribosomal Protein S6 Kinase pp90 rsk, a Homolog of Xenopus S6 Kinase II, in Chicken Embryo Fibroblasts

Molecular and cellular biology, 1990-05, Vol.10 (5), p.2413-2417

1990

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Sequence and Expression of Chicken and Mouse rsk: Homologs of Xenopus laevis Ribosomal S6 Kinase

Molecular and cellular biology, 1989-09, Vol.9 (9), p.3850-3859

1989

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Small-Molecule Ghrelin Receptor Antagonists Improve Glucose Tolerance, Suppress Appetite, and Promote Weight Loss

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity

PDE-10A inhibitors as insulin secretagogues

Raymond L. Erikson (1936–2020)

Raymond L. Erikson (1936–2020)

Synthesis, Structure, and Biological Activity of a New Insulinomimetic Peroxovanadium Compound: Bisperoxovanadium Imidazole Monoanion

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

Discovery of ( S )-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1 H -imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis

Indanylacetic acids as PPAR-δ activator insulin sensitizers

Alteration of intramolecular disulfides in insulin receptor/kinase by insulin and dithiothreitol: insulin potentiates the apparent dithiothreitol-dependent subunit reduction of insulin receptor

Incorporation of the purified human placental insulin receptor into phospholipid vesicles

Substituted indanylacetic acids as PPAR-α–γ activators

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzo f uran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

Dithiothreitol activation of the insulin receptor/kinase does not involve subunit dissociation of the native .alpha.2.beta.2 insulin receptor subunit complex

Two distinct enzymes contribute to biphasic S6 phosphorylation in serum-stimulated chicken embryo fibroblasts

Coinfection of Insect Cells with Recombinant Baculovirus Expressing pp60v-srcResults in the Activation of a Serine-Specific Protein Kinase pp90rsk

Phospholipid activation of the insulin receptor kinase: regulation by phosphatidylinositol

CHARACTERIZATION OF THE PURIFIED AND RECONSTITUTED INSULIN RECEPTOR

Two Distinct Enzymes Contribute to Biphasic S6 Phosphorylation in Serum-Stimulated Chicken Embryo Fibroblasts

Transfer of functional insulin receptors to receptor-deficient target cells

Identification of Mitogen-Responsive Ribosomal Protein S6 Kinase pp90 rsk, a Homolog of Xenopus S6 Kinase II, in Chicken Embryo Fibroblasts

Sequence and Expression of Chicken and Mouse rsk: Homologs of Xenopus laevis Ribosomal S6 Kinase

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