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Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging

Analytical chemistry (Washington), 2018-05, Vol.90 (10), p.6051-6058

2018

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Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging

Scientific reports, 2016-11, Vol.6 (1), p.37648-37648, Article 37648

2016

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Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis

Analytical chemistry (Washington), 2014-08, Vol.86 (16), p.8473-8480

2014

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Evaluation of Formalin-Fixed and FFPE Tissues for Spatially Resolved Metabolomics and Drug Distribution Studies

Pharmaceuticals (Basel, Switzerland), 2022-10, Vol.15 (11), p.1307

2022

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Targeted Desorption Electrospray Ionization Mass Spectrometry Imaging for Drug Distribution, Toxicity, and Tissue Classification Studies

Metabolites, 2023-03, Vol.13 (3), p.377

2023

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Mapping Drug Distribution in Brain Tissue Using Liquid Extraction Surface Analysis Mass Spectrometry Imaging

Analytical chemistry (Washington), 2015-10, Vol.87 (19), p.10146-10152

2015

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Investigating Nephrotoxicity of Polymyxin Derivatives by Mapping Renal Distribution Using Mass Spectrometry Imaging

Chemical research in toxicology, 2015-09, Vol.28 (9), p.1823-1830

2015

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Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review

International journal of mass spectrometry, 2019-03, Vol.437, p.99-112

2019

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GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models

Cancers, 2021-11, Vol.13 (23), p.5939

2021

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Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies

Metabolites, 2022-03, Vol.12 (3), p.261

2022

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Exemplifying the Screening Power of Mass Spectrometry Imaging over Label-Based Technologies for Simultaneous Monitoring of Drug and Metabolite Distributions in Tissue Sections

Journal of biomolecular screening, 2016-02, Vol.21 (2), p.187-193

2016

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Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

Science translational medicine, 2016-02, Vol.8 (325), p.325ra17

2016

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Quantitative Imaging of Proteins in Tissue by Stable Isotope Labeled Mimetic Liquid Extraction Surface Analysis Mass Spectrometry

Analytical chemistry (Washington), 2019-11, Vol.91 (22), p.14198-14202

2019

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Simultaneous quantitation of metformin and sitagliptin from mouse and human dried blood spots using laser diode thermal desorption tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2011-06, Vol.55 (3), p.544-551

2011

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LESA MS Imaging of Heat-Preserved and Frozen Tissue: Benefits of Multistep Static FAIMS

Analytical chemistry (Washington), 2018-11, Vol.90 (22), p.13306-13314

2018

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Determination of metformin in mouse, rat, dog and human plasma samples by laser diode thermal desorption/atmospheric pressure chemical ionization tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2010-11, Vol.53 (3), p.740-744

2010

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Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5951-5964

2012

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Optimization of Brain Penetrant 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.970-986

2014

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Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4‑[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic Acid (AZD8329)

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10136-10147

2012

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11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms

Endocrinology (Philadelphia), 2013-12, Vol.154 (12), p.4580-4593

2013

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Determination of paracetamol in mouse, rat and dog plasma samples by laser diode thermal desorption--APCI-MS/MS

Bioanalysis, 2012-06, Vol.4 (11), p.1327-1335

2012

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Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

Xenobiotica, 2012-11, Vol.42 (11), p.1128-1137

2012

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Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6756-6761

2012

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Mass Spectrometry Methods for Profiling Xenobiotic Distribution in Biofluids and Whole Tissues

Swales, John G

2017

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Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging

Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging

Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis

Evaluation of Formalin-Fixed and FFPE Tissues for Spatially Resolved Metabolomics and Drug Distribution Studies

Targeted Desorption Electrospray Ionization Mass Spectrometry Imaging for Drug Distribution, Toxicity, and Tissue Classification Studies

Mapping Drug Distribution in Brain Tissue Using Liquid Extraction Surface Analysis Mass Spectrometry Imaging

Investigating Nephrotoxicity of Polymyxin Derivatives by Mapping Renal Distribution Using Mass Spectrometry Imaging

Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review

GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models

Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies

Exemplifying the Screening Power of Mass Spectrometry Imaging over Label-Based Technologies for Simultaneous Monitoring of Drug and Metabolite Distributions in Tissue Sections

Correction: Brüning-Richardson et al. GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models. Cancers 2021, 13, 5939

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

Quantitative Imaging of Proteins in Tissue by Stable Isotope Labeled Mimetic Liquid Extraction Surface Analysis Mass Spectrometry

Simultaneous quantitation of metformin and sitagliptin from mouse and human dried blood spots using laser diode thermal desorption tandem mass spectrometry

LESA MS Imaging of Heat-Preserved and Frozen Tissue: Benefits of Multistep Static FAIMS

Determination of metformin in mouse, rat, dog and human plasma samples by laser diode thermal desorption/atmospheric pressure chemical ionization tandem mass spectrometry

Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)

Optimization of Brain Penetrant 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice

Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4‑[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic Acid (AZD8329)

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms

Determination of paracetamol in mouse, rat and dog plasma samples by laser diode thermal desorption--APCI-MS/MS

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors

Mass Spectrometry Methods for Profiling Xenobiotic Distribution in Biofluids and Whole Tissues

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