UB Paderborn / Katalog / Suche / in CDI

Antagonism of the Prostaglandin D₂ Receptor 1 Suppresses Nicotinic Acid-Induced Vasodilation in Mice and Humans

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (17), p.6682-6687

2006

Link zum Volltext

Verfügbarkeit prüfen

Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7073-7083

2013

Link zum Volltext

Verfügbarkeit prüfen

The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects

Communications biology, 2020-11, Vol.3 (1), p.719-719, Article 719

2020

Link zum Volltext

Verfügbarkeit prüfen

Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7440-7443

2010

Link zum Volltext

Verfügbarkeit prüfen

Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: In vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (13), p.3967-3975

2013

Link zum Volltext

Verfügbarkeit prüfen

Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2781-2786

2013

Link zum Volltext

Verfügbarkeit prüfen

Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2775-2780

2013

Link zum Volltext

Verfügbarkeit prüfen

Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor

Bioorganic & medicinal chemistry, 2001-08, Vol.9 (8), p.1977-1984

2001

Link zum Volltext

Verfügbarkeit prüfen

Identification of an indole series of prostaglandin D2 receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.3043-3048

2006

Link zum Volltext

Verfügbarkeit prüfen

Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: Impacts of glutathione trapping and glucuronide conjugation on covalent binding

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (11), p.3038-3043

2007

Link zum Volltext

Verfügbarkeit prüfen

A convenient method for the preparation of acylsulfonamide libraries

Tetrahedron letters, 1998-08, Vol.39 (33), p.5891-5894

1998

Link zum Volltext

Verfügbarkeit prüfen

Samarium(II) Iodide Induced Radical Cyclizations of Halo- and Carbonylhydrazones

Journal of the American Chemical Society, 1994-08, Vol.116 (16), p.7447-7448

1994

Link zum Volltext

Verfügbarkeit prüfen

Antagonism of the prostaglandin D 2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (17), p.6682-6687

2006

Link zum Volltext

Verfügbarkeit prüfen

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3843-3869

2021

Link zum Volltext

Verfügbarkeit prüfen

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2294-2301

2019

Link zum Volltext

Verfügbarkeit prüfen

Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3287-3306

2024

Link zum Volltext

Verfügbarkeit prüfen

A general synthesis of quinolinones and benzothiazine 1,1-dioxides via ring closing metathesis

Tetrahedron letters, 2008-05, Vol.49 (22), p.3677-3681

2008

Link zum Volltext

Verfügbarkeit prüfen

Rate Constants for 5- and 6-Exo Secondary Alkyl Radical Cyclizations onto N,N-Diphenylhydrazones

Journal of organic chemistry, 1994-11, Vol.59 (22), p.6514-6516

1994

Link zum Volltext

Verfügbarkeit prüfen

Comparison of MALDI to ESI on a Triple Quadrupole Platform for Pharmacokinetic Analyses

Analytical chemistry (Washington), 2007-12, Vol.79 (23), p.9000-9006

2007

Link zum Volltext

Verfügbarkeit prüfen

Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524)

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.794-806

2007

Link zum Volltext

Verfügbarkeit prüfen

Formation of Highly Oxygenated [4.4]Spirononenes via Lewis Acid-Catalyzed Isomerization of Adducts to Squarate Esters. Total Synthesis of Dimethyl Gloiosiphone A

Journal of the American Chemical Society, 1996-10, Vol.118 (39), p.9456-9457

1996

Link zum Volltext

Verfügbarkeit prüfen

The PAR2 inhibitor I-287 selectively targets Gα q and Gα 12/13 signaling and has anti-inflammatory effects

Communications biology, 2020-11, Vol.3 (1), p.719

2020

Link zum Volltext

Verfügbarkeit prüfen

The preparation of C-arylglycals. The palladium-catalyzed coupling of 3,4,6-tri-O-(tert-butyldimethylsilyl)-1-(tributylstannyl)-D-glucal and aryl bromides

Journal of organic chemistry, 1990-04, Vol.55 (9), p.2572-2574

1990

Link zum Volltext

Verfügbarkeit prüfen

Observation of .alpha.-silyl carbanions in the metalation of 3,4,6-tri-O-(tert-butyldimethylsilyl)-D-glucal

Journal of organic chemistry, 1991-03, Vol.56 (5), p.1944-1947

1991

Link zum Volltext

Verfügbarkeit prüfen

Stereoselective oxidative spiroketalization of a C-arylglucal derived from palladium-catalyzed coupling. Synthesis of the C-arylglucoside spiroketal nucleus of the papulacandins

Journal of organic chemistry, 1990-11, Vol.55 (23), p.5808-5810

1990

Link zum Volltext

Verfügbarkeit prüfen

Menü

Weitere Dienste

Einstellungen

Antagonism of the Prostaglandin D₂ Receptor 1 Suppresses Nicotinic Acid-Induced Vasodilation in Mice and Humans

Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy

The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects

Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286

Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: In vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors

Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors

Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors

Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor

Identification of an indole series of prostaglandin D2 receptor antagonists

Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: Impacts of glutathione trapping and glucuronide conjugation on covalent binding

A convenient method for the preparation of acylsulfonamide libraries

Samarium(II) Iodide Induced Radical Cyclizations of Halo- and Carbonylhydrazones

Antagonism of the prostaglandin D 2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease

A general synthesis of quinolinones and benzothiazine 1,1-dioxides via ring closing metathesis

Rate Constants for 5- and 6-Exo Secondary Alkyl Radical Cyclizations onto N,N-Diphenylhydrazones

Comparison of MALDI to ESI on a Triple Quadrupole Platform for Pharmacokinetic Analyses

Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524)

Formation of Highly Oxygenated [4.4]Spirononenes via Lewis Acid-Catalyzed Isomerization of Adducts to Squarate Esters. Total Synthesis of Dimethyl Gloiosiphone A

The PAR2 inhibitor I-287 selectively targets Gα q and Gα 12/13 signaling and has anti-inflammatory effects

The preparation of C-arylglycals. The palladium-catalyzed coupling of 3,4,6-tri-O-(tert-butyldimethylsilyl)-1-(tributylstannyl)-D-glucal and aryl bromides

Observation of .alpha.-silyl carbanions in the metalation of 3,4,6-tri-O-(tert-butyldimethylsilyl)-D-glucal

Stereoselective oxidative spiroketalization of a C-arylglucal derived from palladium-catalyzed coupling. Synthesis of the C-arylglucoside spiroketal nucleus of the papulacandins

Suchergebnisse filtern