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In Vitro Screening for Seizure Liability Using Microelectrode Array Technology

Toxicological sciences, 2018-05, Vol.163 (1), p.240-253

2018

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Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

Toxicology and applied pharmacology, 2013-10, Vol.272 (2), p.272-280

2013

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Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells

Cancer research (Chicago, Ill.), 2006-08, Vol.66 (15), p.7509-7515

2006

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Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation-Drug leads for metastatic castration resistant prostate cancer

SLAS discovery, 2023-10, Vol.28 (7), p.325-343

2023

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High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions

Assay and drug development technologies, 2014-09, Vol.12 (7), p.395-418

2014

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Utilization of human induced pluripotent stem cell-derived cardiomyocytes on an MEA platform for prediction of liabilities with chronic drug treatment

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

Strock, Christopher J.

2019

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The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway

Molecular and Cellular Biology, 2003-01, Vol.23 (2), p.543-554

2003

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Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

Cancer research (Chicago, Ill.), 2010-06, Vol.70 (11), p.4460-4469

2010

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Evaluation of pilocarpine in multiple neuronal cell types using microelectrode array

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1683, p.211

2018

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Screening for Neurotoxicity with Microelectrode Array

Current Protocols in Toxicology, 2019-02, Vol.79 (1), p.n/a

2019

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Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor

Assay and drug development technologies, 2019-12, Vol.17 (8), p.364-386

2019

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Activity of Irinotecan and the Tyrosine Kinase Inhibitor CEP-751 in Medullary Thyroid Cancer

The journal of clinical endocrinology and metabolism, 2006-01, Vol.91 (1), p.79-84

2006

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Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes

Toxicological sciences, 2016-11, Vol.154 (1), p.174-182

2016

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High content screening biosensor assay to identify disruptors of p53-hDM2 protein-protein interactions

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1278, p.555

2015

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High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer

Assay and drug development technologies, 2018-08, Vol.16 (6), p.297-319

2018

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Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis

Chemical research in toxicology, 2016-10, Vol.29 (10), p.1778-1788

2016

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Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen

Assay and drug development technologies, 2016-10, Vol.14 (8), p.453-477

2016

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Evaluating the use of microelectrode array technology and cell-based neuronal culture models for proconvulsant risk assessment: progress from the HESI NeuTox consortium

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth

Cancer research (Chicago, Ill.), 2003-09, Vol.63 (17), p.5559-5563

2003

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Implementation of a 220,000-Compound HCS Campaign to Identify Disruptors of the Interaction between p53 and hDM2 and Characterization of the Confirmed Hits

Journal of biomolecular screening, 2010-08, Vol.15 (7), p.766-782

2010

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Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2

Assay and drug development technologies, 2010-08, Vol.8 (4), p.437-458

2010

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Evaluating the pharmacology and neurotoxic predictability of neuroactive compounds using human induced pluripotent stem cell-derived glutamatergic neurons co-cultured with astrocytes using a microelectrode array platform

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.136-137

2018

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Cardiotoxicity evaluation of chronic BMS-986094 exposure in human iPSC-derived cardiomyocytes using a microelectrode array (MEA) assay

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.129-129

2018

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Cellular systems biology profiling applied to cellular models of disease

Combinatorial chemistry & high throughput screening, 2009-11, Vol.12 (9), p.838-848

2009

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In Vitro Screening for Seizure Liability Using Microelectrode Array Technology

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells

Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation-Drug leads for metastatic castration resistant prostate cancer

High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions

Utilization of human induced pluripotent stem cell-derived cardiomyocytes on an MEA platform for prediction of liabilities with chronic drug treatment

The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway

Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

Evaluation of pilocarpine in multiple neuronal cell types using microelectrode array

High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions

Screening for Neurotoxicity with Microelectrode Array

Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor

Activity of Irinotecan and the Tyrosine Kinase Inhibitor CEP-751 in Medullary Thyroid Cancer

Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes

High content screening biosensor assay to identify disruptors of p53-hDM2 protein-protein interactions

High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis

Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen

Evaluating the use of microelectrode array technology and cell-based neuronal culture models for proconvulsant risk assessment: progress from the HESI NeuTox consortium

CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth

Implementation of a 220,000-Compound HCS Campaign to Identify Disruptors of the Interaction between p53 and hDM2 and Characterization of the Confirmed Hits

Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2

Evaluating the pharmacology and neurotoxic predictability of neuroactive compounds using human induced pluripotent stem cell-derived glutamatergic neurons co-cultured with astrocytes using a microelectrode array platform

Cardiotoxicity evaluation of chronic BMS-986094 exposure in human iPSC-derived cardiomyocytes using a microelectrode array (MEA) assay

Cellular systems biology profiling applied to cellular models of disease

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