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Binding Kinetics and Pathways of Ligands to GPCRs

Trends in pharmacological sciences (Regular ed.), 2017-08, Vol.38 (8), p.717-732

2017

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Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors

International journal of molecular sciences, 2021-09, Vol.22 (18), p.9739

2021

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Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations

International journal of molecular sciences, 2021-09, Vol.22 (18), p.10047

2021

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A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes

International journal of molecular sciences, 2020-11, Vol.21 (22), p.8440

2020

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Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions?

Naunyn-Schmiedeberg's archives of pharmacology, 2017-06, Vol.390 (6), p.595-612

2017

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Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity

Molecular pharmacology, 2011-04, Vol.79 (4), p.631-638

2011

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Binding pathway of histamine to the hH4R, observed by unconstrained molecular dynamics

Bioorganic & medicinal chemistry letters, 2015-03, Vol.25 (6), p.1259-1268

2015

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Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H4 Receptor Agonists

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6297-6313

2009

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Comparison of the pharmacological properties of human and rat histamine H3-receptors

Biochemical pharmacology, 2010-11, Vol.80 (9), p.1437-1449

2010

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Contribution of Binding Enthalpy and Entropy to Affinity of Antagonist and Agonist Binding at Human and Guinea Pig Histamine H1-Receptor

Molecular pharmacology, 2009-07, Vol.76 (1), p.25

2009

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Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H 1 Receptor Species Isoforms

The Journal of pharmacology and experimental therapeutics, 2008-01, Vol.324 (1), p.60-71

2008

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Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor

Molecular pharmacology, 2009-11, Vol.76 (5), p.1019-1030

2009

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Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H 1 -Receptor Compared with the Guinea Pig H 1 -Receptor

Molecular pharmacology, 2009-03, Vol.75 (3), p.454-465

2009

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Pharmacological profile of histaprodifens at four recombinant histamine H1 receptor species isoforms

The Journal of pharmacology and experimental therapeutics, 2008-01, Vol.324 (1), p.60

2008

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Trade-offs between social learning and individual innovativeness in common marmosets, Callithrix jacchus

Animal behaviour, 2009-05, Vol.77 (5), p.1291-1301

2009

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3D‐QSAR CoMFA Study to Predict Orientation of Suprahistaprodifens and Phenoprodifens in the Binding‐Pocket of Four Histamine H 1 ‐Receptor Species

Molecular informatics, 2010-04, Vol.29 (4), p.333-341

2010

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Analysis of the activation mechanism of the guinea-pig Histamine H1-receptor

Journal of computer-aided molecular design, 2007-09, Vol.21 (9), p.499-509

2007

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Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation

Naunyn-Schmiedeberg's archives of pharmacology, 2011-09, Vol.384 (3), p.301-317

2011

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Shining light on the histamine H 2 receptor: Synthesis of carbamoylguanidine-type agonists as a pharmacological tool to study internalization

Bioorganic & medicinal chemistry letters, 2021-11, Vol.52, p.128388

2021

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Shining light on the histamine H2 receptor: Synthesis of carbamoylguanidine-type agonists as a pharmacological tool to study internalization

Bioorganic & medicinal chemistry letters, 2021-11, Vol.52, p.128388-128388, Article 128388

2021

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Striking differences of action of lisuride stereoisomers at histamine H1 receptors

Naunyn-Schmiedeberg's archives of pharmacology, 2006-12, Vol.374 (3), p.215-222

2006

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Molecular and cellular analysis of human histamine receptor subtypes

Trends in pharmacological sciences (Regular ed.), 2013-01, Vol.34 (1), p.33-58

2013

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Structure–Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles

Journal of medicinal chemistry, 2018-02, Vol.61 (4), p.1646-1663

2018

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A MiniG Protein Recruitment Assay for the Histamine Receptor Family to Functionally Characterize Histamine Receptor Ligands

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Abolishing Dopamine D 2long /D 3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H 2 Receptor Agonists

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8684-8709

2021

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Binding Kinetics and Pathways of Ligands to GPCRs

Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors

Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations

A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes

Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions?

Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity

Binding pathway of histamine to the hH4R, observed by unconstrained molecular dynamics

Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H4 Receptor Agonists

Comparison of the pharmacological properties of human and rat histamine H3-receptors

Contribution of Binding Enthalpy and Entropy to Affinity of Antagonist and Agonist Binding at Human and Guinea Pig Histamine H1-Receptor

Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H 1 Receptor Species Isoforms

Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor

Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H 1 -Receptor Compared with the Guinea Pig H 1 -Receptor

Pharmacological profile of histaprodifens at four recombinant histamine H1 receptor species isoforms

Trade-offs between social learning and individual innovativeness in common marmosets, Callithrix jacchus

3D‐QSAR CoMFA Study to Predict Orientation of Suprahistaprodifens and Phenoprodifens in the Binding‐Pocket of Four Histamine H 1 ‐Receptor Species

Analysis of the activation mechanism of the guinea-pig Histamine H1-receptor

Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation

Shining light on the histamine H 2 receptor: Synthesis of carbamoylguanidine-type agonists as a pharmacological tool to study internalization

Shining light on the histamine H2 receptor: Synthesis of carbamoylguanidine-type agonists as a pharmacological tool to study internalization

Striking differences of action of lisuride stereoisomers at histamine H1 receptors

Molecular and cellular analysis of human histamine receptor subtypes

Structure–Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles

A MiniG Protein Recruitment Assay for the Histamine Receptor Family to Functionally Characterize Histamine Receptor Ligands

Abolishing Dopamine D 2long /D 3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H 2 Receptor Agonists

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