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Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Journal of translational medicine, 2020-04, Vol.18 (1), p.179-9, Article 179

2020

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Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

International journal of molecular sciences, 2021-11, Vol.22 (21), p.11779

2021

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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Nature communications, 2017-06, Vol.8 (1), p.15772-15772, Article 15772

2017

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Structural basis of the specificity of USP18 toward ISG15

Nature structural & molecular biology, 2017-03, Vol.24 (3), p.270-278

2017

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Molecular architecture of the glycogen- committed PP1/PTG holoenzyme

Nature communications, 2022-10, Vol.13 (1), p.6199-6199, Article 6199

2022

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Identification of Inhibitors of SARS-CoV‑2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

ACS pharmacology & translational science, 2021-06, Vol.4 (3), p.1096-1110

2021

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PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Molecular cancer therapeutics, 2007-12, Vol.6 (12), p.3158-3168

2007

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Crystal Structure of Osmoporin OmpC from E. coli at 2.0 Å

Journal of molecular biology, 2006-10, Vol.362 (5), p.933-942

2006

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Identification of Novel GSK-3β Hits Using Competitive Biophysical Assays

International journal of molecular sciences, 2022-03, Vol.23 (7), p.3856

2022

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Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC

Bioorganic chemistry, 2022-12, Vol.129, p.106219-106219, Article 106219

2022

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Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

International journal of molecular sciences, 2021-01, Vol.22 (3), p.1293

2021

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Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

Molecules (Basel, Switzerland), 2020-02, Vol.25 (4), p.935

2020

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Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

International journal of molecular sciences, 2019-10, Vol.20 (20), p.5219

2019

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Synthesis, Characterization, and Optimization for in Vivo Delivery of a Nonselective Isopeptidase Inhibitor as New Antineoplastic Agent

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1691-1704

2015

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PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

Clinical cancer research, 2006-07, Vol.12 (13), p.4080-4089

2006

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Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3532-3551

2010

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L‐serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase

Protein science, 2023-04, Vol.32 (4), p.e4609-n/a

2023

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Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route

European journal of medicinal chemistry, 2022-12, Vol.244, p.114853-114853, Article 114853

2022

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Investigating Drug–Target Residence Time in Kinases through Enhanced Sampling Simulations

Journal of chemical theory and computation, 2019-08, Vol.15 (8), p.4646-4659

2019

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Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors

European journal of medicinal chemistry, 2021-11, Vol.223, p.113638-113638, Article 113638

2021

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Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design

Physical chemistry chemical physics : PCCP, 2024-09, Vol.26 (35), p.22853-22857

2024

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A consensus protocol for the in silico optimisation of antibody fragments

Chemical communications (Cambridge, England), 2019-11, Vol.55 (93), p.14043-14046

2019

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Binding of tyrosine kinase inhibitor to epidermal growth factor receptor: surface-enhanced infrared absorption microscopy reveals subtle protein secondary structure variations

Nanoscale, 2021-04, Vol.13 (16), p.7667-7677

2021

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Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination

European journal of medicinal chemistry, 2023-05, Vol.253, p.115311-115311, Article 115311

2023

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Structural characterization of the PTG and PTG/PP1 complex

Acta crystallographica. Section A, Foundations and advances, 2021-08, Vol.77 (a2), p.C855-C855

2021

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Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Structural basis of the specificity of USP18 toward ISG15

Molecular architecture of the glycogen- committed PP1/PTG holoenzyme

Identification of Inhibitors of SARS-CoV‑2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Crystal Structure of Osmoporin OmpC from E. coli at 2.0 Å

Identification of Novel GSK-3β Hits Using Competitive Biophysical Assays

Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC

Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

Synthesis, Characterization, and Optimization for in Vivo Delivery of a Nonselective Isopeptidase Inhibitor as New Antineoplastic Agent

PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

L‐serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase

Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route

Investigating Drug–Target Residence Time in Kinases through Enhanced Sampling Simulations

Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors

Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design

A consensus protocol for the in silico optimisation of antibody fragments

Binding of tyrosine kinase inhibitor to epidermal growth factor receptor: surface-enhanced infrared absorption microscopy reveals subtle protein secondary structure variations

Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination

Structural characterization of the PTG and PTG/PP1 complex

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