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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

PloS one, 2020-12, Vol.15 (12), p.e0240338

2020

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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1862-1878

2015

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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

PLoS pathogens, 2015-06, Vol.11 (6), p.e1004995-e1004995

2015

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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

International journal of molecular sciences, 2023-11, Vol.24 (22), p.16274

2023

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Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

PloS one, 2016-05, Vol.11 (5), p.e0154097-e0154097

2016

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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Antimicrobial Agents and Chemotherapy, 2008-12, Vol.52 (12), p.4432-4441

2008

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Nucleosides for the treatment of respiratory RNA virus infections

Antiviral chemistry & chemotherapy, 2018-01, Vol.26, p.2040206618764483-2040206618764483

2018

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Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior

Biochemistry (Easton), 2009-03, Vol.48 (11), p.2559-2568

2009

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Differential Associations of Childhood Abuse and Neglect with Adult Autonomic Regulation and Mood-Related Pathology

Psychosomatic medicine, 2023-10

2023

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The influence of neuropeptide Y (NPY) on the relationship between emotion regulation and mood-related pathology in survivors of childhood interpersonal trauma

Journal of affective disorders, 2024-10, Vol.362, p.258-262

2024

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Brain derived neurotrophic factor and treatment outcomes among veterans attending an intensive treatment program for posttraumatic stress disorder

Journal of psychiatric research, 2024-05, Vol.173, p.1-5

2024

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Scoring the Life Events Checklist: Comparison of Three Scoring Methods

Psychological trauma, 2022-05, Vol.14 (4), p.714-720

2022

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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH

Journal of medicinal chemistry, 2024-09, Vol.67 (17), p.14840-14851

2024

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Event centrality and posttraumatic stress symptoms after traumatic injury: A longitudinal investigation

Journal of traumatic stress, 2022-12, Vol.35 (6), p.1734-1743

2022

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A documentary video assignment to enhance learning in large first-year science classes

International Journal of Innovation in Science and Mathematics Education, 2014-01, Vol.22 (4), p.48-64

2014

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Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase

ACS chemical biology, 2017-01, Vol.12 (1), p.83-91

2017

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Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs

Bioorganic & medicinal chemistry, 2013-09, Vol.21 (17), p.5461-5469

2013

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Optimization of the multiple enzymatic activities of the hepatitis C virus NS3 protein

Analytical biochemistry, 2009-11, Vol.394 (1), p.138-140

2009

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Regulation of gene transcription by thyroid hormone receptor [beta] agonists in clinical development for the treatment of non-alcoholic steatohepatitis

PloS one, 2020-12, Vol.15 (12), p.e0240338

2020

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Gene Structure, Dual-promoters and mRNA Alternative Splicing of the Human and Mouse Regulator of G Protein Signaling GAIP/RGS19

Journal of molecular biology, 2003-01, Vol.325 (4), p.721-732

2003

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Toward Antiviral Therapies for the Treatment of Zika Virus Infection: Lessons Learned from Dengue Virus

Neglected Tropical Diseases, 2019, p.15-47

2019

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PIRFENIDONE ATTENUATES TRANSFORMING GROWTH FACTOR-BETA-INDUCED ACTIVATION OF P38-ALPHA AND P38-GAMMA MITOGEN–ACTIVATED PROTEIN KINASES IN HUMAN LUNG FIBROBLASTS: IMPLICATIONS FOR TREATMENT OF FIBROTIC LUNG DISEASES

Chest, 2006-10, Vol.130 (4), p.114S-114S

2006

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PIRFENIDONE IN COMBINATION WITH INTERFERON GAMMA-1B INHIBITS OSTEOPONTIN-INDUCED ALVEOLAR EPITHELIAL CELL PROLIFERATION AND ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASES

Chest, 2006-10, Vol.130 (4), p.230S-230S

2006

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The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Nucleosides for the treatment of respiratory RNA virus infections

Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior

Differential Associations of Childhood Abuse and Neglect with Adult Autonomic Regulation and Mood-Related Pathology

The influence of neuropeptide Y (NPY) on the relationship between emotion regulation and mood-related pathology in survivors of childhood interpersonal trauma

Brain derived neurotrophic factor and treatment outcomes among veterans attending an intensive treatment program for posttraumatic stress disorder

Scoring the Life Events Checklist: Comparison of Three Scoring Methods

Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH

Event centrality and posttraumatic stress symptoms after traumatic injury: A longitudinal investigation

A documentary video assignment to enhance learning in large first-year science classes

Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase

Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs

Optimization of the multiple enzymatic activities of the hepatitis C virus NS3 protein

Regulation of gene transcription by thyroid hormone receptor [beta] agonists in clinical development for the treatment of non-alcoholic steatohepatitis

Gene Structure, Dual-promoters and mRNA Alternative Splicing of the Human and Mouse Regulator of G Protein Signaling GAIP/RGS19

Toward Antiviral Therapies for the Treatment of Zika Virus Infection: Lessons Learned from Dengue Virus

PIRFENIDONE ATTENUATES TRANSFORMING GROWTH FACTOR-BETA-INDUCED ACTIVATION OF P38-ALPHA AND P38-GAMMA MITOGEN–ACTIVATED PROTEIN KINASES IN HUMAN LUNG FIBROBLASTS: IMPLICATIONS FOR TREATMENT OF FIBROTIC LUNG DISEASES

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate: e1004995

PIRFENIDONE IN COMBINATION WITH INTERFERON GAMMA-1B INHIBITS OSTEOPONTIN-INDUCED ALVEOLAR EPITHELIAL CELL PROLIFERATION AND ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASES

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