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Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Cell, 2015-01, Vol.160 (3), p.489-502

2015

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Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (41), p.16412-16413

2012

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Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (24), p.E5497-E5505

2018

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Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

Nature communications, 2014-05, Vol.5 (1), p.3901, Article 3901

2014

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Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (30), p.12426-12431

2013

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Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

Cancer research (Chicago, Ill.), 2016-02, Vol.76 (3), p.724-735

2016

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Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges

Pharmacogenomics, 2015-07, Vol.16 (10), p.1149-1160

2015

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Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases

Science signaling, 2018-04, Vol.11 (526)

2018

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Somatically mutated ABL1 is an actionable and essential NSCLC survival gene

EMBO molecular medicine, 2016-02, Vol.8 (2), p.105-116

2016

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Improved Production and Biophysical Analysis of Recombinant Silicatein-α

Biomolecules (Basel, Switzerland), 2020-08, Vol.10 (9), p.1209

2020

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Abstract 4408: Mutant ABL1 is a genetic dependency in non-small cell lung cancer amenable to pharmacological intervention

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4408-4408

2016

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Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability

FEBS open bio, 2015-01, Vol.5 (1), p.625-633

2015

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A launch vector for the production of vaccine antigens in plants

Influenza and other respiratory viruses, 2007-01, Vol.1 (1), p.19-25

2007

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Effects of disruption of epiphyseal vasculature on the proximal femoral growth plate

Journal of bone and joint surgery. American volume, 2009-05, Vol.91 (5), p.1149

2009

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Diversity, Equality, and Inclusion in Caribbean Organisations and Society: An Exploration of Work, Employment, Education, and the Law

1st Edition 2020, 2020

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Protein Kinase Cα (PKCα) Gain‐of‐Function Variant in Alzheimer's Disease Displays Enhanced Catalysis by a Mechanism that Evades Down‐Regulation

The FASEB journal, 2018-04, Vol.32 (S1), p.662.7-662.7

2018

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Protein Kinase Cδ Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell‐Defective Apoptosis and Hyperproliferation

Arthritis & rheumatology (Hoboken, N.J.), 2013-08, Vol.65 (8), p.2161-2171

2013

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Protein kinase Ca gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (24), p.E5497

2018

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Closed-Set Speech Discrimination Tests for Assessing Young Children

Ear and hearing, 2018-01, Vol.39 (1), p.32-41

2018

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Prevalence of inactivating protein kinase C mutations in human cancers (1055.2)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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Abstract 5270: Prevalence of inactivating protein kinase C mutations in human cancers

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5270-5270

2014

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Abstract 125: Protein kinase C loss-of-function mutations in cancer reveal role as tumor suppressor

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.125-125

2015

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Designing and developing a mobile application to prepare paediatric cancer patients for proton therapy

Design for health (Abingdon, England), 2018-01, Vol.2 (1), p.77-88

2018

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Somatically mutated ABL 1 is an actionable and essential NSCLC survival gene

EMBO molecular medicine, 2016-02, Vol.8 (2), p.105-116

2016

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Mechanotransduction of the Notch Signalling Pathway via the Negative Regulatory Region

Stephenson, Natalie Louise

2013

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Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region

Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges

Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene

Improved Production and Biophysical Analysis of Recombinant Silicatein-α

Abstract 4408: Mutant ABL1 is a genetic dependency in non-small cell lung cancer amenable to pharmacological intervention

Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability

A launch vector for the production of vaccine antigens in plants

Effects of disruption of epiphyseal vasculature on the proximal femoral growth plate

Diversity, Equality, and Inclusion in Caribbean Organisations and Society: An Exploration of Work, Employment, Education, and the Law

Protein Kinase Cα (PKCα) Gain‐of‐Function Variant in Alzheimer's Disease Displays Enhanced Catalysis by a Mechanism that Evades Down‐Regulation

Protein Kinase Cδ Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell‐Defective Apoptosis and Hyperproliferation

Protein kinase Ca gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation

Closed-Set Speech Discrimination Tests for Assessing Young Children

Prevalence of inactivating protein kinase C mutations in human cancers (1055.2)

Abstract 5270: Prevalence of inactivating protein kinase C mutations in human cancers

Abstract 125: Protein kinase C loss-of-function mutations in cancer reveal role as tumor suppressor

Designing and developing a mobile application to prepare paediatric cancer patients for proton therapy

Somatically mutated ABL 1 is an actionable and essential NSCLC survival gene

Mechanotransduction of the Notch Signalling Pathway via the Negative Regulatory Region

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