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Protein kinase C: poised to signal

American journal of physiology: endocrinology and metabolism, 2010-03, Vol.298 (3), p.E395-E402

Newton, Alexandra C

2010

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Protein kinase C pharmacology: refining the toolbox

Biochemical journal, 2013-06, Vol.452 (2), p.195-209

2013

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Turning off AKT: PHLPP as a drug target

Annual review of pharmacology and toxicology, 2014-01, Vol.54 (1), p.537-558

2014

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Lipid activation of protein kinases

Journal of lipid research, 2009-04, Vol.50 (Suppl), p.S266-S271

Newton, Alexandra C.

2009

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Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Cell, 2015-01, Vol.160 (3), p.489-502

2015

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

Biochemical journal, 2003-03, Vol.370 (Pt 2), p.361-371

Newton, Alexandra C

2003

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PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms

Molecular cell, 2007-03, Vol.25 (6), p.917-931

2007

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Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

Chemical reviews, 2001-08, Vol.101 (8), p.2353-2364

Newton, Alexandra C

2001

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Protein kinase C: perfectly balanced

Critical reviews in biochemistry and molecular biology, 2018-04, Vol.53 (2), p.208-230

Newton, Alexandra C.

2018

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PHLiPPing the switch on Akt and protein kinase C signaling

Trends in endocrinology and metabolism, 2008-08, Vol.19 (6), p.223-230

2008

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The Phosphatase PHLPP Controls the Cellular Levels of Protein Kinase C

The Journal of biological chemistry, 2008-03, Vol.283 (10), p.6300-6311

2008

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Protein kinase C mechanisms that contribute to cardiac remodelling

Clinical science (1979), 2016-09, Vol.130 (17), p.1499

2016

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Tuning the signalling output of protein kinase C

Biochemical Society transactions, 2014-12, Vol.42 (6), p.1477

2014

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Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer

Molecular cell, 2019-04, Vol.74 (2), p.378-392.e5

2019

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Protein kinase C as a tumor suppressor

Seminars in cancer biology, 2018-02, Vol.48, p.18-26

Newton, Alexandra C

2018

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

The EMBO journal, 2008-07, Vol.27 (14), p.1932-1943

2008

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Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt

Molecular cell, 2014-05, Vol.54 (3), p.378-391

2014

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Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling

The Journal of biological chemistry, 2012-02, Vol.287 (6), p.3610-3616

2012

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Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression

Cancer cell, 2011-08, Vol.20 (2), p.173-186

2011

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Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

Nature communications, 2020-11, Vol.11 (1), p.6088-6088, Article 6088

2020

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Spatiotemporal Dynamics of Phosphorylation in Lipid Second Messenger Signaling

Molecular & cellular proteomics, 2013-12, Vol.12 (12), p.3498-3508

2013

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Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Nature communications, 2022-11, Vol.13 (1), p.7200-7200, Article 7200

2022

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Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation

The Journal of biological chemistry, 2015-06, Vol.290 (26), p.16272-16280

2015

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Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

Cell reports (Cambridge), 2015-08, Vol.12 (8), p.1252-1260

2015

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PKCα Is Recruited to Staphylococcus aureus- Containing Phagosomes and Impairs Bacterial Replication by Inhibition of Autophagy

Frontiers in immunology, 2021-03, Vol.12, p.662987-662987

2021

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Protein kinase C: poised to signal

Protein kinase C pharmacology: refining the toolbox

Turning off AKT: PHLPP as a drug target

Lipid activation of protein kinases

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

Protein kinase C: perfectly balanced

PHLiPPing the switch on Akt and protein kinase C signaling

The Phosphatase PHLPP Controls the Cellular Levels of Protein Kinase C

Protein kinase C mechanisms that contribute to cardiac remodelling

Tuning the signalling output of protein kinase C

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer

Protein kinase C as a tumor suppressor

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt

Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling

Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

Spatiotemporal Dynamics of Phosphorylation in Lipid Second Messenger Signaling

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

PKCα Is Recruited to Staphylococcus aureus- Containing Phagosomes and Impairs Bacterial Replication by Inhibition of Autophagy

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