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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

PloS one, 2017-06, Vol.12 (6), p.e0179278

2017

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Arginine methylation regulates the p53 response

Nature cell biology, 2008-12, Vol.10 (12), p.1431-1439

2008

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Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models

British journal of cancer, 2020-10, Vol.123 (9), p.1424-1436

2020

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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Nature communications, 2024-05, Vol.15 (1), p.4430-4430, Article 4430

2024

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Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives

PloS one, 2012-12, Vol.7 (12), p.e50889-e50889

2012

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ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

BMC cancer, 2022-10, Vol.22 (1), p.1-1107, Article 1107

2022

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Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

Nature chemical biology, 2016-10, Vol.12 (10), p.815-821

2016

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Telomerase-independent paths to immortality in predictable cancer subtypes

Journal of Cancer, 2012-01, Vol.3 (1), p.67-82

Durant, Stephen T

2012

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Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Free radical biology & medicine, 2015-11, Vol.88 (Pt B), p.108-146

2015

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The SET Domain Protein Metnase Mediates Foreign DNA Integration and Links Integration to Nonhomologous End-Joining Repair

Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (50), p.18075-18080

2005

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Good Timing in the Cell Cycle for Precise DNA Repair by BRCA1

Cell cycle (Georgetown, Tex.), 2005-09, Vol.4 (9), p.1216-1222

2005

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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Nature communications, 2019-01, Vol.10 (1), p.87-18, Article 87

2019

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ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis

Clinical cancer research, 2023-11, Vol.29 (21), p.4492-4503

2023

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p53 methylation-the Arg-ument is clear

Cell cycle (Georgetown, Tex.), 2009-03, Vol.8 (6), p.801-802

2009

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ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156

Science translational medicine, 2021-08, Vol.13 (607)

2021

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CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors

Proceedings of the National Academy of Sciences - PNAS, 2023-02, Vol.120 (6), p.e2212072120-e2212072120

2023

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Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390

Journal of medicinal chemistry, 2024-02, Vol.67 (4), p.3090-3111

2024

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UV Radiation Induces Delayed Hyperrecombination Associated with Hypermutation in Human Cells

Molecular and Cellular Biology, 2006-08, Vol.26 (16), p.6047-6055

2006

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Development of a high-throughput fluorescence polarization DNA cleavage assay for the identification of FEN1 inhibitors

Journal of biomolecular screening, 2013-06, Vol.18 (5), p.567-575

2013

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Metnase promotes restart and repair of stalled and collapsed replication forks

Nucleic acids research, 2010-09, Vol.38 (17), p.5681-5691

2010

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Abstract PO-017: Radiotherapy in combination with the brain penetrant ATM inhibitor AZD1390 does not exacerbate radiation toxicity of neural stem cells in vitro or in vivo

Clinical cancer research, 2021-04, Vol.27 (8_Supplement), p.PO-017-PO-017

2021

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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

Arginine methylation regulates the p53 response

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)

Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives

ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

Telomerase-independent paths to immortality in predictable cancer subtypes

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

The SET Domain Protein Metnase Mediates Foreign DNA Integration and Links Integration to Nonhomologous End-Joining Repair

Good Timing in the Cell Cycle for Precise DNA Repair by BRCA1

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis

p53 methylation-the Arg-ument is clear

ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156

CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)

Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

UV Radiation Induces Delayed Hyperrecombination Associated with Hypermutation in Human Cells

Development of a high-throughput fluorescence polarization DNA cleavage assay for the identification of FEN1 inhibitors

Metnase promotes restart and repair of stalled and collapsed replication forks

Abstract PO-017: Radiotherapy in combination with the brain penetrant ATM inhibitor AZD1390 does not exacerbate radiation toxicity of neural stem cells in vitro or in vivo

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