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The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation

Clinical pharmacology and therapeutics, 2017-10, Vol.102 (4), p.591-598

Rose‐John, Stefan

2017

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Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing

The American journal of pathology, 2018-02, Vol.188 (2), p.474-490

2018

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The shedding protease ADAM17: Physiology and pathophysiology

Biochimica et biophysica acta. Molecular cell research, 2017-11, Vol.1864 (11), p.2059-2070

2017

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IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6

International journal of biological sciences, 2012-01, Vol.8 (9), p.1237-1247

Rose-John, Stefan

2012

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Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer

FEBS letters, 2022-03, Vol.596 (5), p.557-566

Rose‐John, Stefan

2022

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Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance

Angewandte Chemie International Edition, 2021-06, Vol.60 (24), p.13380-13387

International ed. in English, 2021

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IL-6 pathway in the liver: From physiopathology to therapy

Journal of hepatology, 2016-06, Vol.64 (6), p.1403-1415

2016

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Therapeutic targeting of IL-6 trans-signaling

Cytokine (Philadelphia, Pa.), 2021-08, Vol.144, p.155577-155577, Article 155577

Rose-John, Stefan

2021

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Inhibition of IL‐6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer

International journal of cancer, 2015-09, Vol.137 (5), p.1035-1046

2015

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Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

Journal of leukocyte biology, 2006-08, Vol.80 (2), p.227-236

2006

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Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA

Journal of neurochemistry, 2021-06, Vol.157 (6), p.1821-1837

2021

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Idiopathic multicentric Castleman disease with marrow fibrosis and extramedullary hematopoiesis

European journal of haematology, 2024-12, Vol.113 (6), p.833-841

2024

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ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

EMBO molecular medicine, 2019-04, Vol.11 (4), p.1-n/a

2019

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Interleukin-6 and its receptors: A highly regulated and dynamic system

Cytokine (Philadelphia, Pa.), 2014-11, Vol.70 (1), p.11-20

2014

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Interleukin-6 signalling in health and disease [version 1; peer review: awaiting peer review]

F1000 research, 2020, Vol.9, p.1013

Rose-John, Stefan

2020

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Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6

Angewandte Chemie International Edition, 2014-11, Vol.53 (45), p.12125-12131

2014

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Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis

EMBO molecular medicine, 2022-08, Vol.14 (8), p.e15653-n/a

2022

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Senescence‐associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

The FASEB journal, 2014-11, Vol.28 (11), p.4847-4856

2014

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IL-6 biology: implications for clinical targeting in rheumatic disease

Nature reviews. Rheumatology, 2014-12, Vol.10 (12), p.720-727

2014

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Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

Seminars in immunology, 2014-02, Vol.26 (1), p.2-12

2014

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Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis

Hepatology (Baltimore, Md.), 2017-05, Vol.65 (5), p.1600-1611

2017

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Genetic partitioning of interleukin‐6 signalling in mice dissociates Stat3 from Smad3‐mediated lung fibrosis

EMBO molecular medicine, 2012-09, Vol.4 (9), p.939-951

2012

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Mechanisms of interorgan crosstalk in health and disease

FEBS letters, 2022-03, Vol.596 (5), p.529-533

2022

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Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions

Journal of leukocyte biology, 2013-10, Vol.94 (4), p.791-802

2013

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The pro- and anti-inflammatory properties of the cytokine interleukin-6

Biochimica et biophysica acta, 2011-05, Vol.1813 (5), p.878-888

2011

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The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation

Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing

The shedding protease ADAM17: Physiology and pathophysiology

IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6

Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer

Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance

IL-6 pathway in the liver: From physiopathology to therapy

Therapeutic targeting of IL-6 trans-signaling

Inhibition of IL‐6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA

Idiopathic multicentric Castleman disease with marrow fibrosis and extramedullary hematopoiesis

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

Interleukin-6 and its receptors: A highly regulated and dynamic system

Interleukin-6 signalling in health and disease [version 1; peer review: awaiting peer review]

Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6

Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis

Senescence‐associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

IL-6 biology: implications for clinical targeting in rheumatic disease

Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis

Genetic partitioning of interleukin‐6 signalling in mice dissociates Stat3 from Smad3‐mediated lung fibrosis

Mechanisms of interorgan crosstalk in health and disease

Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions

The pro- and anti-inflammatory properties of the cytokine interleukin-6

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