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Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (44), p.16078-16083

2005

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GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers

Molecular cancer therapeutics, 2009-10, Vol.8 (10), p.2811-2820

2009

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Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats

The Journal of pharmacology and experimental therapeutics, 2008-07, Vol.326 (1), p.41

2008

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.360-364

2009

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Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

Organic letters, 2005-10, Vol.7 (21), p.4753-4756

2005

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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1694-1697

2009

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The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5428-5430

2008

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Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.3136-3140

2009

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.469-473

2009

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Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.373-377

2009

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Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines

Journal of organic chemistry, 2008-12, Vol.73 (23), p.9511-9514

2008

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Synthesis of novel anilinoquinolines as c-fms inhibitors

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6257-6260

2007

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An Enantiospecific Synthesis of the Human Cytomegalovirus Antiviral Agent [(R)-3-((2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic Acid

Journal of medicinal chemistry, 1994-04, Vol.37 (9), p.1371-1377

1994

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New methodologies for the synthesis of C-2 functionalized hypoxanthine nucleosides

Journal of organic chemistry, 1988-06, Vol.53 (13), p.3051-3057

1988

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Design, Synthesis, and Antiviral Activity of α-Nucleosides: d- and l-Isomers of Lyxofuranosyl- and (5-Deoxylyxofuranosyl)benzimidazoles

Journal of medicinal chemistry, 1998-04, Vol.41 (8), p.1242-1251

1998

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DMPK and Metabolism Studies of Nucleoside Phosphoramidates Including INX-08189, A Novel Double Pro-drug and Clinical Candidate for Hepatitis C Virus Therapy

Antiviral research, 2011-05, Vol.90 (2), p.A22-A23

2011

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Novel approaches to functionalized nucleosides via palladium-catalyzed cross coupling with organostannanes

Journal of the American Chemical Society, 1987-11, Vol.109 (23), p.7223-7224

1987

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Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1 H -pyrrolo[2,3- d ]pyrimidines

Journal of organic chemistry, 2008-12, Vol.73 (23), p.9511-9514

2008

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Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.21-26

2009

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Novel photoinduced functionalized C-alkylations in purine systems

Journal of organic chemistry, 1985-12, Vol.50 (25), p.5069-5075

1985

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Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.373-377

2009

Volltextzugriff (PDF)

Discovery of 3,5-disubstituted-lH-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (11), p.3136-3140

2009

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Di- and triester prodrugs of the varicella-zoster antiviral agent 6-methoxypurine arabinoside

Journal of medicinal chemistry, 1992-01, Vol.35 (1), p.56-63

1992

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Corrigendum to “Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding” [Bioorg. Med. Chem. Lett. 19 (2009) 1694]

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2604-2604

2009

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Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.360-364

2009

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Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580

GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers

Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors

Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines

Synthesis of novel anilinoquinolines as c-fms inhibitors

An Enantiospecific Synthesis of the Human Cytomegalovirus Antiviral Agent [(R)-3-((2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic Acid

New methodologies for the synthesis of C-2 functionalized hypoxanthine nucleosides

Design, Synthesis, and Antiviral Activity of α-Nucleosides: d- and l-Isomers of Lyxofuranosyl- and (5-Deoxylyxofuranosyl)benzimidazoles

DMPK and Metabolism Studies of Nucleoside Phosphoramidates Including INX-08189, A Novel Double Pro-drug and Clinical Candidate for Hepatitis C Virus Therapy

Novel approaches to functionalized nucleosides via palladium-catalyzed cross coupling with organostannanes

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1 H -pyrrolo[2,3- d ]pyrimidines

Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors

Novel photoinduced functionalized C-alkylations in purine systems

Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Discovery of 3,5-disubstituted-lH-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Di- and triester prodrugs of the varicella-zoster antiviral agent 6-methoxypurine arabinoside

Corrigendum to “Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding” [Bioorg. Med. Chem. Lett. 19 (2009) 1694]

Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

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